A5101601114- Pulmonary Hypertension Research and Treatments
- Eicosanoids and Hypertension Pharmacology
- Circadian rhythm and melatonin
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Renin-Angiotensin System Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Sodium Intake and Health
- Neuroscience of respiration and sleep
- Breastfeeding Practices and Influences
- COVID-19 Impact on Reproduction
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer, Stress, Anesthesia, and Immune Response
- Hemoglobinopathies and Related Disorders
- Gut microbiota and health
- Microbial metabolism and enzyme function
- Child Nutrition and Water Access
- Sarcoidosis and Beryllium Toxicity Research
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Atherosclerosis and Cardiovascular Diseases
- Nitric Oxide and Endothelin Effects
- Pharmacological Receptor Mechanisms and Effects
- Horticultural and Viticultural Research
- Neonatal Respiratory Health Research
- Aortic Thrombus and Embolism
University of Florida
2017-2024
Florida College
2018-2023
Royal Brompton Hospital
1987-2022
Western Regional Hospital
2019
Topiwala National Medical College & BYL Nair Charitable Hospital
2018
Luton and Dunstable Hospital
2017
Regent University College of Science and Technology
2016
National Institute of Technology Raipur
2015
Samsung Medical Center
2013
AstraZeneca (United States)
2003
Rationale: Increased microglial activation and neuroinflammation within autonomic brain regions have been implicated in sustained hypertension, their inhibition by minocycline—an anti-inflammatory antibiotic—produces beneficial effects. These observations led us to propose a dysfunctional brain-gut communication hypothesis for hypertension. However, it has difficult reconcile whether an or antimicrobial action is the primary effect of minocycline Accordingly, we utilized chemically modified...
Therapeutic advances for pulmonary hypertension (PH) have been incremental because of the focus on vasculature in PH pathology. Here, we evaluate concept that is, rather, a systemic disorder involving interplay among multiorgan systems, including brain, gut, and lungs. Therefore, objective this study was to hypothesis is associated with dysfunctional brain-gut-lung axis global overexpression ACE2 (angiotensin-converting enzyme 2) rebalances protects against PH. knockin wild-type (WT;...
Activation of autonomic neural pathways by chronic hypertensive stimuli plays a significant role in pathogenesis hypertension. Here, we proposed that even single acute stimulus will activate and immune may be important initiation memory imprinting seen We investigated the effects angiotensin II (Ang II) administration on blood pressure, activation cardioregulatory brain regions, central systemic responses, at 1 24 hour post-injection. Administration bolus intra-peritoneal (I.P.) injection...
Pulmonary hypertension (PH) is a devastating disease and its successful treatment remains to be accomplished despite recent advances in pharmacotherapy. It has been proposed that PH considered as systemic disease, rather than primarily of the pulmonary vasculature. Consequently, an investigation intricate interplay between multiple organs such brain, vasculature, lung could lead identification new targets for therapy. However, little known about this interplay. This study was undertaken...
Emerging evidence implicates an interplay among multiple organs such as brain, vasculature, gut and lung in the development of established pulmonary arterial hypertension (PAH). This has led us to propose that activated microglia mediated-enhanced sympathetic activation contributes PAH pathophysiology. Since enhanced activity is observed human highly innervated by nerves regulate its physiological functions, we hypothesized would be associated with A monocrotaline rat model was utilized...
Hydrogen sulfide (H 2 S) is a gaseous signaling molecule with neuromodulatory, anti-inflammatory, and anti-hypertensive effects. Here, we investigate whether chronic intracerebroventricular (ICV) infusion of sodium hydrosulfide (NaHS), an H S donor, can alleviate angiotensin II (Ang II)–induced hypertension (HTN), improve autonomic function, impact microglia in the paraventricular nucleus (PVN) hypothalamus, brain region associated control blood pressure (BP) neuroinflammation HTN. Chronic...
Abstract Heart failure with preserved ejection fraction (HFpEF) patients who develop pulmonary hypertension (PH) have an increased risk of death, combined pre- and post-capillary PH (CpcPH) having the highest risk. However, mechanism behind development in HFpEF is poorly understood. We aimed to identify transcriptomic associations HFpEF. Blood was collected from 30 patients: 10 without PH, isolated CpcPH. Gene expression measurements were completed using transcriptome-wide RNA sequencing....
Patients with chronic kidney disease (CKD) are at increased risk for adverse cardiovascular events. CKD is associated increases in arterial stiffness, whereas improvements stiffness correlate better survival. However, early CKD, suggesting that there might be additional factors, unique to disease, increase stiffness. Lysyl oxidase (LOX) a key mediator of collagen cross linking and matrix remodeling. LOX predominantly expressed the system, its upregulation has been tissue stiffening...
Antagonists (e.g., Ziconotide, Gabapentin) of the CaV2.2 (N-type) calcium channels are used clinically as analgesics for chronic pain. However, their use is limited by narrow therapeutic windows, difficult dosing routes (Ziconotide), misuse and overdoses (Gabapentin), well a litany adverse effects. Expansion novel pain therapeutics may emerge from mechanism-based interrogation CaV2.2. Here we report identification C2230, an aryloxy-hydroxypropylamine, blocker. C2230 trapped stabilized...
Recent evidence suggests pulmonary hypertension (PH), a disease of the vasculature actually has multiorgan pathophysiology and perhaps etiology. Herein, we demonstrated that fecal matter transplantation from angiotensin-converting enzyme 2 overexpressing mice counteracted effects chronic hypoxia to prevent hypertension, neuroinflammation, gut dysbiosis in wild type recipients.
In this paper, we have determined the severity of Thalassemia disease in a patient with help their Red Blood Cell (RBC) indices components such as Mean Corpuscular Hemoglobin (MCH) and corpuscular volume (MCV). Also level blood (Hemoglobin) is considered. We use fuzzy application, Mamdani Fuzzy Inference System (FIS) to generate model for diagnosis. Obtained applied on set data that 15 results are similar 3 marginally off. It shows accuracy proposed system 83.3%. Sensitivity analysis carried...
Background: Poor child feeding practices and sub-optimal breastfeeding have a detrimental effect on health of children less than 2 years age. We studied the as well complementary in <2 age our tertiary institute with help WHO2008 document, Indicators for assessing infant young (IYCF) practices.Methods: This cross-sectional study was carried out asymptomatic (< years), care hospital using pre-designed, validated WHO questionnaire information regarding practices.Results: The mean hours,...
Background Our previous studies have established that activation of microglial cells and neuro‐inflammation in autonomic brain regions, particularly the paraventricular nucleus (PVN) hypothalamus, plays a critical role hypertension (HTN). This conclusion is primarily based on evidence tetracycline antibiotic minocycline (Mino) inhibits attenuates HTN. Since Mino has both anti‐inflammatory properties, we sought to determine property responsible for its antihypertensive effects using...