A5052185950- Pain Mechanisms and Treatments
- Heart Rate Variability and Autonomic Control
- Laser Applications in Dentistry and Medicine
- Pulmonary Hypertension Research and Treatments
- Cardiac Ischemia and Reperfusion
- Neonatal and fetal brain pathology
- ECG Monitoring and Analysis
- Neurological Disorders and Treatments
- Anesthesia and Neurotoxicity Research
- Anesthesia and Pain Management
- Clinical Nutrition and Gastroenterology
- Heavy Metal Exposure and Toxicity
- Cardiac electrophysiology and arrhythmias
- Intensive Care Unit Cognitive Disorders
- Congenital Heart Disease Studies
- Ocular and Laser Science Research
- Hemodynamic Monitoring and Therapy
- Blood Pressure and Hypertension Studies
- Botulinum Toxin and Related Neurological Disorders
- Effects of Radiation Exposure
- Cardiovascular Effects of Exercise
- Retinopathy of Prematurity Studies
- S100 Proteins and Annexins
- Laser-Ablation Synthesis of Nanoparticles
- Electromagnetic Fields and Biological Effects
Mersin Üniversitesi
2012-2025
University of Milan
2004
University of Brescia
2004
Erythropoietin (EPO) possesses generalized neuroprotective and neurotrophic actions. We tested the efficacy of recombinant human EPO (rhEPO) in preventing reversing nerve dysfunction streptozotocin (STZ)-induced diabetes rats. Two days after STZ [60 mg/kg body weight (b.w.), i.p.], diabetic animals were administered rhEPO (40 μg/kg b.w.) three times weekly for 5 weeks either immediately (preventive) before or a 5-week delay (therapeutic) induction hyperglycemia at lower dose (8 b.w. once per...
In this study, the systemic hemodynamics induced by acute and chronic cadmium (Cd+2) intoxication in cardiovascular system of rats using thoracic electrical bioimpedance were examined effects Cd+2 on activities antioxidant enzymes malondialdehyde (MDA) compared. Also, ultrastructural changes heart aorta evaluated. Thirty-eight male Wistar albino randomly divided into control, acute, groups. Chronic group was administered oral gavage an aqueous solution CdCl2 for 60 days, at dose 15 mg...
We evaluated the acute electrophysiologic effects of low-energy pulsed laser irradiation, measured by extracellular recording technique on compound action potential configuration and nerve excitability in isolated frog sciatic nerveA gallium-arsenide (GaAs) (wavelength, 904 nm; pulse duration, 220 nanoseconds; peak power per pulse, 27 W; spot size, 0.28 cm(2); total applied energy density, 0.005-2.5 J/cm(2)) was used for experiment. Sixty nerves were divided into six groups (n = 10), each...
In this study, Cadmium (Cd) genotoxicity was investigated in both bone marrow and peripheral blood treatment using rat micronucleus technique as test at acute chronic the same animals. This study evaluated frequency of micronuclei male rats treated with unique cadmium dose (15 mg/kg. body w/day) by gavage for 60 days 24 h, respectively. Mitomycin C (MMC) 2 mg/kg wt used a positive control. shows that chloride significantly induced polychromatic erythrocytes tibia (p < 0.001, p 0.01,...
Abstract Electrocardiography (ECG) signals and the information obtained through analysis of these constitute main source diagnosis for many cardiovascular system diseases. Therefore, accurate analyses ECG are very important correct diagnosis. In this study, an toolbox together with a user-friendly graphical user interface, which contains all steps between recording unit statistical investigation, is developed. Furthermore, new feature calculation methodology proposed analysis, carries...
Cardiovascular abnormalities are widespread when a newborn is exposed to hypoxic-ischemic injury in the neonatal period. Although neuroprotective effects of levetiracetam (LEV) have been reported after hypoxia, cardioprotective LEV not documented. Therefore, we aimed investigate whether has protective effect on cardiac-contractility and ultrastructure heart muscle rats hypoxia-ischemia (HI) during A total 49 seven-day-old rat pups were separated into four groups. For HI induction,...
AimTo evaluate the effects of bosentan, sildenafil, and combined therapy on cardiovascular system using impedance cardiography (ICG) in rats with monocrotaline (MCT)-induced pulmonary arterial hypertension (PAH).MethodsSeventy male Wistar-albino were randomized into five groups. A single dose MCT was given to all rats, except control group. After 4 weeks, treatment started lasted for 3 weeks. The last group that developed PAH did not receive any medication. Echocardiographic evaluation...
In this study, the effect of low energy Gallium arsenide (GaAs) laser irradiation on compound action potential frog gastrocnemius muscle were investigated.Sixty frogs divided into different six dose groups: 1 (1 Hz), 2 ( 4 3 (16 (64 5 (128 and 6 (1,000 Hz, DC, continue) (in each group n=10). Low GaAs (wavelenght: 904 nm, pulsed duration: 220 nanoseconds, peak power per pulse: 27 W, total applied density: 0.001-25.7 J/cm2) was used for experiment. Compound potentials recorded before these...
Low muscle glutamine levels during sepsis are associated with reduced protein synthesis and elevated breakdown, in particular myofibrillar breakdown. Thus, a cecal ligation puncture (CLP)-induced model the rat, we hypothesized that pretreatment would protect diaphragm function.Eighty-four male Wistar rats weighing between 180 g 200 received standard amino acid solution 1.2 kg(-1) per day intraperitoneally (IP) or plus alanyl-glutamine (GLN) 0.25 first 6 days of experiment. On seventh day,...
Neonatal hypoxic-ischemic (HI) injury has been considered to have acute and long term deleterious effects on many tissues, including the peripheral nerve.In this study, of a tumor necrosis factor-alpha (TNF-a) inhibitor (etanercept) nerve damage ultrastructure sciatic gastrocnemius muscle in rats exposed HI during neonatal period were examined.In 45 seven-day-old used they divided into three groups. The right carotid arteries saline etanercept groups ligated put hypoxia chamber containing 8%...
AbstractPurpose Neurological impairments are the leading cause of post-stroke mortality, while stroke-related cardiovascular diseases rank second in significance. This study investigates potential protective effects MitoTEMPO (2,2,6,6-tetramethyl-4-[[2-(triphenylphosphonio) acetyl] amino]-1-piperidinyloxy, monochloride, monohydrate), a mitochondria-specific antioxidant, against cardiac and neurological complications following stroke. The objective is to assess whether can be utilized as...
Background : Low muscle glutamine levels during sepsis are associated with reduced protein synthesis and elevated breakdown, in particular myofibrillar breakdown. Thus, a cecal ligation puncture (CLP)‐induced model the rat, we hypothesized that pretreatment would protect diaphragm function. Methods Eighty‐four male Wistar rats weighing between 180 g 200 received standard amino acid solution 1.2 kg −1 per day intraperitoneally (IP) or plus alanyl‐glutamine (GLN) 0.25 first 6 days of...
Purpose Acute lower extremity ischemia is still a main cause of mortality and morbidity in orthopedic traumatology reconstructive surgery. In acute ischemia, the skeletal muscles are tissues that most vulnerable to ischemia. The aim this study was evaluate effects iloprost (IL) therapy on muscle contractile impairment mitochondrial degeneration an ischemia-reperfusion rat model. Main Methods Forty Wistar albino rats were randomly divided into control group four experimental groups....
The aim of the present study was to systematically investigate effects chronic exposure extremely low-frequency electromagnetic field (ELF-EMF) on electrophysiological, histological and biochemical properties diaphragm muscle in rats. Twenty-nine newly weaned (24 days old, 23-80 g) female (n = 15) male 14) Wistar Albino rats were used this study. animals randomly divided into two groups: control group (EMF) group. also EMF ELF-EMF groups exposed for 4 h daily up 7 months 50 Hz frequency, 1.5...
Pulmonary arterial hypertension (PAH) is a challenging disorder characterized by increasing pulmonary artery pressure, which hard to treat.This study was aimed investigate the effects of bosentan, sildenafil and their combination.Saline or MCT were applied Wistar rats. By development PAH (4th week), MCT-given rats treated orally with combination bosentan placebo. ECHO examinations performed. Tissues obtained from all evaluated under an electron microscope.Left ventricular end diastolic...
BACKGROUND AND OBJECTIVES: This study was aimed to examine how inotropic effects of intravenously injected epinephrine change thoracic impedance measurements and reveal the possible this on other hemodynamic parameters by using technique cardiography.METHODS: 10 male Wistar Albino rats were divided into two equal groups: control epinephrine.0.2 mg/kg administered in group via tail vein.All obtained cardiography [the base (Z 0 ), maximum rate (dZmax/dt), left ventricular ejection time (LVET),...