Histopathologic changes in rat brain due to chronic use of morphine and/or tramadol progressively increased doses were investigated this study. Thirty male Wistar rats (180-220 g) included and divided into three groups. Normal saline (1 ml/kg) was given intraperitoneally as placebo the control group (n = 10). Morphine 10) received at a dose 4 mg/kg/day for first 10 days, 8 between 11-20 12 21-30 days. The drug 20, 40, 80 first, second, third days study, respectively. All decapitated on 30th...

Recent experimental studies have described protective effect of ischemic preconditioning (IPC) on ischemia-reperfusion (I/R) injury the intestine. We hypothesize that to reach a new point view IPC in intestinal barrier function, relationship between I/R-induced mucosal and apoptosis must first be clarified. The present study was undertaken investigate role probable contributions bcl-2 expression this process. also investigated ileal malondyaldihyde levels. Forty-four male Wistar rats were...

Intrathecal morphine has been used in hopes of providing long-lasting postoperative analgesia patients after cardiac surgery. The aim this study was to evaluate the effects 7 micro/kg intrathecal administration coronary bypass surgery period.We conducted a prospective, randomized, blinded, and controlled study. Twenty-three patients, who underwent primary elective surgery, were randomly allocated receive intrathecally, before induction general anesthesia (Group M, n = 12) or no injection C,...

<i>Objectives:</i> To examine in a prospective, randomized, double-blind, placebo-controlled study the analgesic effect of periprostatic nerve block and/or intravenous synthetic opioid administration during 12-core prostate biopsy. <i>Patients and Methods:</i> Patients were prospectively randomized to receive unilateral lidocaine (meperidine or tramadol) administration. Placebo groups received sterile normal saline. Unilateral infiltration was performed biopsy begun...

The aim of this study was to evaluate the effect serratus anterior plane block in addition intrathecal morphine for early postoperative period after video-assisted thoracoscopic surgery on amount consumption and Visual Analog Scale scores.This single-blind, randomized-controlled included a total 64 patients (39 males, 25 females; mean age: 53.6±17.0 years; range, 20 89 years) who were scheduled tertiary hospital between September 2019 March 2020. Postoperative pain control achieved with 0.6...

Low muscle glutamine levels during sepsis are associated with reduced protein synthesis and elevated breakdown, in particular myofibrillar breakdown. Thus, a cecal ligation puncture (CLP)-induced model the rat, we hypothesized that pretreatment would protect diaphragm function.Eighty-four male Wistar rats weighing between 180 g 200 received standard amino acid solution 1.2 kg(-1) per day intraperitoneally (IP) or plus alanyl-glutamine (GLN) 0.25 first 6 days of experiment. On seventh day,...

Abstract Background and Methods With the increasing rate of breast cancer surgery, pain management these patients gains importance. The aim this study is to compare ultrasound (US) guided thoracic paravertebral block (TPV) versus intraoperative pectoral nerve (PECS) with a low volume local anaesthetic for postoperative analgesia after surgery. A total 41 underwent mastectomy sentinel lymph node biopsy or modified radical were included in randomized controlled, single‐blinded trial. divided...

Objectives A multimodal approach to pain management, including potential interventional techniques, is suggested achieve adequate control. This study discusses the techniques and medications employed manage in pediatric oncology patients. Methodology included 90 patients under 18 years of age who underwent management algology clinic between 2002 2020. From follow-up records, following data were recorded: demographic information, time, cancer diagnosis stage, cause location pain, systems...

Background : Low muscle glutamine levels during sepsis are associated with reduced protein synthesis and elevated breakdown, in particular myofibrillar breakdown. Thus, a cecal ligation puncture (CLP)‐induced model the rat, we hypothesized that pretreatment would protect diaphragm function. Methods Eighty‐four male Wistar rats weighing between 180 g 200 received standard amino acid solution 1.2 kg −1 per day intraperitoneally (IP) or plus alanyl‐glutamine (GLN) 0.25 first 6 days of...

Spinal myoclonus following regional anaesthesia is extremely rare.We report a patient who developed spinal after an epidural infusion of levobupivacaine.

This case report presents a rare instance of simultaneous bilateral avascular necrosis (AVN) affecting both the humeral and femoral heads in 49-year-old male patient recovering from severe COVID-19. The was treated with high-dose corticosteroids, receiving 1250 mg prednisolone over five days during hospitalization for COVID-19 pneumonia. Six months after discharge, he developed persistent hip pain, which later diagnosed as AVN heads. During hyperbaric oxygen therapy, reported new shoulder an...

Background/Objectives: Recurrent lumbar disc herniation (RLDH) refers to a (LDH) that recurs at the same level, location, and side following surgical repair. This study aimed evaluate efficacy of transforaminal epidural steroid injection (TESI) dorsal root ganglion pulsed radiofrequency (DRG PRF) therapy with without caudal (CESI) for treatment radicular pain (LRP) associated RLDH. Methods: retrospective cohort included 57 patients treated RLDH in hospital clinic between September 2022...

Pain control is one of the major concerns after hip surgeries. Suprainguinal fascia iliaca compartment block (S-FICB) an alternative analgesic technique that can be considered as effective and less invasive method than epidural analgesia (EA). In this retrospective study, we compared postoperative efficacy single shot ultrasound guided S-FICB EA surgery.We retrospectively examined 150 patients who underwent surgeries received or EA. Seventy-two submitted to 78 were included their medical...

This study aimed to evaluate the effectiveness of adding caudal epidural steroid injection (CESI) ganglion impar pulsed radiofrequency (GI-PRF) therapy in patients with refractory chronic coccygodynia, and determine effect pain duration trauma on treatment success.

Chronic lumbar facet pain is commonly treated with fluoroscopy-guided medial branch blocks (FMBBs). However, the associated radiation exposure of both patients and clinicians a growing concern. This study aimed to compare doses fluoroscopy times between two techniques, i.e., oblique posterior–anterior (PA) fluoroscopic approaches, while also examining impact physician experience on these metrics. A retrospective analysis was conducted 180 at Mersin University Hospital Pain Clinic January...