A5005230150- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Robotic Path Planning Algorithms
- Modular Robots and Swarm Intelligence
- Acute Myocardial Infarction Research
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Disease and Adiposity
- Distributed Control Multi-Agent Systems
- Control and Dynamics of Mobile Robots
- Peripheral Artery Disease Management
- Teleoperation and Haptic Systems
- Atherosclerosis and Cardiovascular Diseases
- Gaze Tracking and Assistive Technology
- Optical Coherence Tomography Applications
- Transplantation: Methods and Outcomes
- Human-Automation Interaction and Safety
- Antiplatelet Therapy and Cardiovascular Diseases
- Advanced MRI Techniques and Applications
- Angiogenesis and VEGF in Cancer
- Robotic Locomotion and Control
- Cardiac Structural Anomalies and Repair
- Muscle activation and electromyography studies
- Robot Manipulation and Learning
Kishiwada Tokushukai Hospital
2023-2025
Tokyo University of Technology
2013-2022
Wakayama Medical University
2012-2021
Mayo Clinic
2012-2019
WinnMed
2019
Kinan Hospital
2008-2016
Wakayama University
2014-2016
Kyoto University Hospital
2015
The Christie NHS Foundation Trust
2015
Mayo Clinic in Arizona
2012-2015
AimsCardiac allograft vasculopathy (CAV) is a major limitation to long-term survival following cardiac transplantation. Conventional imaging modalities such as angiography and intravascular ultrasound fail characterize CAV plaque morphology. Our aim was in vivo using the high spatial resolution of intracoronary optical coherence tomography (OCT).
Both the number and function of bone marrow-derived endothelial progenitor cells (EPCs) have been shown to be impaired in patients with diabetes mellitus. Therefore, we investigated effect glucose on senescence EPCs.EPCs were isolated from human peripheral blood characterized evaluate (in 5-12.5 mmol/L) rate by acidic beta-galactosidase staining. The phosphorylation p38 mitogen-activated protein kinase (MAPK) level was analyzed ELISA. exposure cultured EPC high (HG; 12.5 significantly...
Objective— Endothelial dysfunction is an early manifestation of atherosclerosis. Inflammation and vasa vasorum play a pivotal role in the pathophysiology plaque initiation, development, complications. Optical coherence tomography allows high-resolution imaging tissue microstructure. Therefore, aim this study was to test hypothesis that segments with endothelial show macrophages patients coronary artery disease. Approach Results— images were obtained from 40 mild atherosclerosis who underwent...
Stent edge restenosis (SER) remains a potential limitation of drug-eluting stents. The aim this study was to determine optical coherence tomography (OCT) predictors for angiographic late SER after everolimus-eluting stent implantation.We retrospectively analyzed 319 patients who underwent OCT immediately implantation and scheduled 9- 12-month follow-up angiography. binary rate 10% (32/319) in the patients, 8.4% (32/382) lesions, 4.4% (33/744) segments. In segments at post stenting,...
Abstract Background Late Gadolinium Enhancement (LGE) in cardiac MRI marks myocardial fibrosis and irreversible damage. In aortic stenosis (AS), LGE helps assess damage, crucial for risk stratification treatment planning. The Placement of Aortic Transcatheter Valves (PARTNER) trial's staging system, based on echocardiographic parameters, stratifies patients from stages 0 to 4. While this indicates prognosis, the extent remains unclear. Objectives To clarify frequency positivity across...
Abstract Background Aortic stenosis (AS) is prevalent among the elderly. Accurate prognostic assessment in AS crucial for optimizing patient management and outcomes. Identifying factors associated with Late Gadolinium Enhancement (LGE), a cardiac MRI marker, can help risk stratification. LGE-positive individuals have poorer prognosis, including twofold increased of mortality adverse cardiovascular events. Purpose The purpose this study was to identify echocardiographic predictors LGE...
1. Bone marrow-derived endothelial progenitor cells (EPC) in the peripheral blood of adult animals and humans have been shown to be incorporated into neovascularization. In contrast, hypercholesterolaemia impairs angiogenesis collateral vessel formation response regional tissue ischaemia. We investigated whether oxidized LDL (oxLDL) affected human EPC differentiation. 2. When isolated mononuclear (MNC) were incubated with vascular growth factor (VEGF), number differentiated, adherent EPC, as...
AimsThe importance of oxidized low-density lipoprotein (oxLDL) has been implicated in the process plaque rupture. However, few previous studies demonstrated relationship between morphology and oxLDL. We evaluated coronary vulnerability assessed by optical coherence tomography (OCT) circulating malondialdehyde-modified (MDA-LDL).
A novel index of the functional severity coronary stenosis, quantitative flow ratio (QFR), may not consider amount viable myocardium in prior myocardial infarction (MI) because QFR is calculated from 3D angiography.Methods and Results:We analyzed (fixed-flow [fQFR] contrast-flow [cQFR]) fractional reserve (FFR) prior-MI-related arteries (n=75) non-prior-MI-related (n=75). Both fQFR cQFR directly correlated with FFR (fQFR: r=0.84, P<0.001; cQFR: r=0.88, P<0.001) r=0.91, r=0.94, P<0.001). was...
Quantitative flow ratio (QFR) is a novel physiological index of the severity coronary stenosis. The aim present study was to investigate relationship between QFR and instantaneous wave-free (iFR).We analyzed contrast-flow QFR, iFR, fractional reserve (FFR) in 100 arteries with intermediate stenosis.There high correlation (r=0.71, P<0.001) good agreement (mean difference: -0.09±0.11) iFR. Both iFR were correlated significantly FFR (r=0.89, P<0.001 r=0.76, P<0.001, respectively). mean absolute...