A5072062005- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- Cardiovascular Function and Risk Factors
- Acute Myocardial Infarction Research
- Cardiovascular Disease and Adiposity
- Advanced MRI Techniques and Applications
- Cardiac Valve Diseases and Treatments
- Optical Coherence Tomography Applications
- Cardiovascular Health and Disease Prevention
- Cerebrovascular and Carotid Artery Diseases
- Cardiac Arrhythmias and Treatments
- Cardiac Structural Anomalies and Repair
- Peripheral Artery Disease Management
- Sarcoidosis and Beryllium Toxicity Research
- Atherosclerosis and Cardiovascular Diseases
- Aortic aneurysm repair treatments
- Adipose Tissue and Metabolism
- Cardiac pacing and defibrillation studies
- Infective Endocarditis Diagnosis and Management
- Coronary Artery Anomalies
- Pericarditis and Cardiac Tamponade
- Aortic Thrombus and Embolism
- Advanced X-ray and CT Imaging
- Congenital Heart Disease Studies
- Medical Imaging Techniques and Applications
Kishiwada Tokushukai Hospital
2021-2025
Osaka Kyoiku University
2024
Osaka Health Science University
2021
Osaka Prefectural Education Center
2017-2021
Wakayama Medical University
2008-2019
Wakayama University
2008-2016
American Heart Association
2014
Columbia University
2003-2008
Saiseikai Kumamoto Hospital
2008
Osaka City University
1993-2006
BEEN IDEN-2][3][4][5][6] In 1992, the American Heart Association concluded that risk of death due to heart disease is increased by about 30% among those exposed environmental tobacco smoke at home, and could be much higher in workplace, where levels may present. 1There evidence exposure nonsmokers breaks down serum antioxidant defenses 7 associated with impairment endotheliumdependent function arterial walls. 8However, acute effects passive smoking on coronary circulation have not been...
Lipoprotein lipase is the principal enzyme that hydrolyzes circulating triglycerides and liberates free fatty acids can be used as energy by cardiac muscle. Although lipoprotein expressed found on surface of cardiomyocytes, its transfer to luminal endothelial cells thought required for actions. To study whether nontransferable has physiological actions, we placed an α-myosin heavy-chain promoter upstream a human minigene construct with glycosylphosphatidylinositol anchoring sequence carboxyl...
Background Normal values for echocardiographic measurements and the relationship between these parameters age in a large Japanese population are still unknown. Methods Results A total of 700 healthy aged 20-79 years underwent 2-dimensional Doppler echocardiography at collaborating institutions. The respective mean obtained men women were as follows: septal wall thickness, 0.9±0.1 0.8±0.1 cm; posterior left ventricular (LV) diastolic diameter, 4.8±0.4 4.4±0.3 LV systolic 3.0±0.4 2.8±0.3...
Although some recent guidelines recommend an early invasive strategy for non-ST-segment elevation acute coronary syndrome (NSTEACS), several studies have failed to identify any benefit very intervention NSTEACS. The no-reflow phenomenon may inhibit the expected from recanalization NSTEACS subjects. aim of this study was investigate whether optical coherence tomography (OCT) could predict in patients with NSTEACS.This comprised 83 consecutive who underwent OCT and successful emergent primary...
Background— Plaque rupture and secondary thrombus formation play key roles in the onset of acute coronary syndrome (ACS). One pathological study suggested that morphologies plaque differed between rest-onset exertion-triggered men who experienced sudden death. The aim present was to use optical coherence tomography investigate relationship patients with ACS morphology a ruptured patient’s activity at ACS. Methods Results— population drawn from 43 consecutive (with or without ST-segment...
Intracoronary optical coherence tomography (OCT) is a high-resolution imaging modality used for evaluation of coronary lesion morphology. However, current time-domain OCT (TD-OCT) have number limitations with regard to both procedural usage and safety in the clinical setting. The next-generation frequency-domain (FD-OCT), which has much faster frame rate pullback speed than TD-OCT, expected overcome these limitations. aim this study was evaluate feasibility usability next generation FD-OCT...
Vascular dysfunction in the coronary and peripheral circulations is an early prognostic marker of future cardiovascular events. Measurements vascular function resistance vessels can be made, but rely on invasive procedures, which make them unsuitable for routine application. An assessment direct correlation between responses skin has not been made previously. In 27 normal healthy subjects (18-55 years age), we examined relationship function. Cutaneous perfusion was measured using...
Alpha glucosidase inhibitor (GI) attenuates postprandial hyperglycemia (PPH) and reduces the risk of cardiovascular events in patients with impaired glucose tolerance or type 2 diabetes. Dipeptidyl peptidase 4 (DPP-4) inhibitors also attenuate PPH. PPH is one factors leading to endothelial dysfunction which an early event pathogenesis atherosclerosis. Furthermore, DPP-4 protect function through a GLP-1-dependent mechanism. However, impact these two types drugs on diabetes has not been fully...
Long-chain fatty acids (FAs) are the predominant energy substrate utilized by adult heart. The heart can utilize unesterified FA bound to albumin or obtained from lipolysis of lipoprotein-bound triglyceride (TG). We used heart-specific lipoprotein lipase knock-out mice (hLpL0) test whether these two sources interchangeable and necessary for optimal function. Hearts unable obtain TG were able compensate increasing glucose uptake, glycolysis, oxidation. HLpL0 hearts had decreased expression...
Background: Although an intracoronary frequency-domain optical coherence tomography (FD-OCT) system overcomes several limitations of the time-domain OCT (TD-OCT) system, former requires injection contrast media for image acquisition. The increased total amount FD-OCT acquisition may lead to impairment renal function. safety and usefulness non-occlusion method with low-molecular-weight dextran L (LMD-L) via a guiding catheter TD-OCT have been reported previously. aim present study was compare...
Background: The recently developed real-time 3-dimensional echocardiography (RT3DE) is a promising imaging method to quantify cardiac chamber volumes and their functions in clinical practice. However, normal reference values of RT3DE parameters have not been fully investigated large, healthy Japanese population. Methods Results: This study consisted 410 subjects aged from 20 69 years who had at one the 23 collaborating institutions. All no history disease risk factors. mean men women were as...
Background: For the identification of functionally significant coronary artery disease, there have not been any dedicated optical coherence tomography (OCT) studies reported previously, although OCT can clearly detect vessel lumina at higher resolution than intravascular ultrasound (IVUS). Methods and Results: fractional flow reserve (FFR) measurements were performed in 62 intermediate lesions 59 patients. FFR was calculated as ratio distal pressure divided by proximal during maximal...
Lipid accumulation is associated with cardiac dysfunction in diabetes and obesity. Transgenic mice expressing non-transferable lipoprotein lipase (LpL) a glycosylated phosphatidyl-inositol (GPI) anchor cardiomyocytes have dilated cardiomyopathy. However, the mechanisms responsible for lipid cardiomyopathy are not clear. Hearts from 3-month-old GPI-anchored human LpL (hLpLGPI) had increased fatty acid oxidation heart failure genes decreased glucose transporter genes. 6-month-old mRNA...