A5100352419- Neuropeptides and Animal Physiology
- Folate and B Vitamins Research
- Cardiac Ischemia and Reperfusion
- Liver Disease Diagnosis and Treatment
- Adipokines, Inflammation, and Metabolic Diseases
- Immune Cell Function and Interaction
- Parathyroid Disorders and Treatments
- Peroxisome Proliferator-Activated Receptors
- Receptor Mechanisms and Signaling
- Adipose Tissue and Metabolism
- Immune cells in cancer
- Cancer, Hypoxia, and Metabolism
- Chemokine receptors and signaling
- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- Cholesterol and Lipid Metabolism
- Diabetes and associated disorders
- Pain Mechanisms and Treatments
- Peptidase Inhibition and Analysis
- Atherosclerosis and Cardiovascular Diseases
- Galectins and Cancer Biology
- Hormonal Regulation and Hypertension
- Cardiac Arrest and Resuscitation
- Inflammatory mediators and NSAID effects
- Immune Response and Inflammation
Anhui Medical University
2018-2025
Sir Run Run Shaw Hospital
2015-2025
Zhejiang University
2015-2025
Nanjing Maternity and Child Health Care Hospital
2022-2025
Nanjing Medical University
2022-2025
Second Hospital of Anhui Medical University
2021-2025
Peking University
2015-2024
Northwest University
2024
Shanghai Maritime University
2024
First Affiliated Hospital of Anhui Medical University
2021-2023
<h3>Importance</h3> Uncertainty remains about the efficacy of folic acid therapy for primary prevention stroke because limited and inconsistent data. <h3>Objective</h3> To test hypothesis that with enalapril is more effective in reducing first than alone among Chinese adults hypertension. <h3>Design, Setting, Participants</h3> The China Stroke Primary Prevention Trial, a randomized, double-blind clinical trial conducted from May 19, 2008, to August 24, 2013, 32 communities Jiangsu Anhui...
Hypoxia-inducible factor (HIF) 1 α is a metabolic regulator that plays an important role in immunologic responses. Previous studies have demonstrated HIF1 participates the M1 polarization of macrophages. To clarify mechanism -induced macrophage, myeloid-specific overexpression (Lysm lsl) mice were employed and bone marrow-derived peritoneal macrophages isolated. RT-PCR results revealed macrophage had hyperinflammatory state characterized by upregulation markers. Cellular bioenergetics...
Objective— Endothelial activation is implicated in atherogenesis and diabetes. The role of peroxisome proliferator-activated receptor-δ (PPAR-δ) endothelial remains poorly understood. In this study, we investigated the anti-inflammatory effect PPAR-δ mechanism involved. Methods Results— human umbilical vein cells (HUVECs), synthetic ligands GW0742 GW501516 significantly inhibited tumor necrosis factor (TNF)-α–induced expression vascular cell adhesion molecule-1 E-selectin (assayed by...
Primary nonalcoholic fatty liver disease is one of the most common forms chronic diseases and associated with insulin-resistant states such as diabetes obesity. Recent work has revealed potential implications peroxisome proliferator-activated receptor-δ (PPARδ) in lipid homeostasis insulin resistance. In this study, we examined effect PPARδ on sterol regulatory element-binding protein-1 (SREBP-1), a pivotal transcription factor controlling lipogenesis hepatocytes. Treatment GW0742, agonist,...
Background— ADAMTS-7, a member of the disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) family, was recently identified to be significantly associated genomewide coronary artery disease. However, mechanisms that link ADAMTS-7 disease risk remain elusive. We have previously demonstrated promotes vascular smooth muscle cell migration postinjury neointima formation via degradation matrix protein cartilage oligomeric protein. Because delayed endothelium repair renders...
Vascular calcification significantly increases cardiovascular morbidity and mortality. We recently reported that the deficiency of cartilage oligomeric matrix protein (COMP) leads to vascular mineralization. characterized COMP-degrading metalloproteinase, a disintegrin metalloproteinase with thrombospondin motifs-7 (ADAMTS-7). Here, we tested whether ADAMTS-7 facilitates calcification.ADAMTS-7 expression was markedly upregulated in calcifying rat smooth muscle cells (VSMCs) vitro, calcified...
Endothelial dysfunction induced by hyperhomocysteinemia (HHcy) plays a critical role in vascular pathology. However, little is known about the of endoplasmic reticulum (ER) redox homeostasis HHcy-induced endothelial dysfunction. Here, we show that Hcy induces ER oxidoreductin-1α (Ero1α) expression with stress and inflammation human umbilical vein cells arteries HHcy mice. upregulates Ero1α promoting binding hypoxia-inducible factor 1α to ERO1A promoter. Notably, rather than other thiol...
Obesity-induced adipose dysfunction is a major contributor to atherosclerosis. Cold exposure has been reported affect atherosclerosis through regulation of function, but the mechanism not well clarified. Here, adipocyte hypoxia-inducible factor 2α (HIF-2α) was upregulated after mild cold at 16°C and mediated cold-induced thermogenesis. Adipocyte HIF-2α deficiency exacerbated Western-diet-induced by increasing ceramide levels, which blunted hepatocyte cholesterol elimination Mechanistically,...
Type 2 diabetes is a chronic inflammatory metabolic disease, the key point being insulin resistance. Endoplasmic reticulum (ER) stress plays critical role in pathogenesis of type diabetes. Previously, we found that hyperhomocysteinemia (HHcy) induced resistance adipose tissue. Here, hypothesized HHcy induces ER stress, which turn promotes In present study, direct effect Hcy on was investigated by use primary rat adipocytes vitro and mice with vivo. The mechanism G protein-coupled receptor...
Diabetic kidney disease (DKD) is one of the microvascular complications diabetes mellitus and a major cause end-stage renal with limited treatment options. Wogonin flavonoid derived from root Scutellaria baicalensis Georgi, which has shown potent renoprotective effect. But mechanisms action in DKD are not fully elucidated. In this study, we investigated effects wogonin on glomerular podocytes using mouse podocyte clone 5 (MPC5) cells diabetic mice model. MPC5 were treated high glucose (30...
Particulate matter with an aerodynamic diameter less than 2.5 μM (PM2.5) is one of the major environmental pollutants in China. In this study, we carried out a metabolomics profile study on PM2.5-induced inflammation. PM2.5 from Beijing, China, was collected and given to rats through intra-tracheal instillation vivo. Acute pulmonary injury were observed by function assessment H.E. staining. The lipid metabolic also altered increased phospholipid sphingolipid metabolites broncho-alveolar...
Background: The metalloprotease ADAMTS-7 (a disintegrin and metalloproteinase with thrombospondin type 1 motif 7) is a novel locus associated human coronary atherosclerosis. deletion protects against atherosclerosis vascular restenosis in rodents. Methods: We designed 3 potential vaccines consisting of distinct B cell epitopic peptides derived from conjugated the carrier protein KLH (keyhole limpet hemocyanin) as well aluminum hydroxide an adjuvant. Arterial ligation or wire injury was used...
Abdominal aortic aneurysm (AAA) is a lethal cardiovascular disease, and there no proven drug treatment for this condition. In study, by using the Connectivity Map (CMap) approach, we explored naringenin, naturally occurring citrus flavonoid, as putative agent inhibiting AAA. We then validated prediction with two independent mouse models of AAA, calcium phosphate (CaPO4)-induced C57BL/6J mice angiotensin II-infused ApoE-/- mice. Naringenin effectively blocked formation AAAs progression...
The pathophysiological mechanism of acute kidney injury (AKI) is complicated, and effective drugs are still lacking. Ferroptosis a newly discovered regulatory cell death mode characterized by the lethal accumulation iron reactive oxygen species-(ROS-)-dependent lipid hydroperoxides. In recent years, ferroptosis has been confirmed to be involved in progression AKI. Paeoniflorin (PF) traditional Chinese medicine that protective effects on variety diseases including However, which PF attenuates...
Abstract Hyperhomocysteinemia (HHcy) is a risk factor for chronic kidney diseases (CKDs) that affects about 85% CKD patients. HHcy stimulates B cells to secrete pathological antibodies, although it unknown whether this pathway mediates injury. In HHcy-treated 2-kidney, 1-clip (2K1C) hypertensive murine model, HHcy-activated secreted anti-beta 2 glycoprotein I (β GPI) antibodies deposited in glomerular endothelial (GECs), exacerbating glomerulosclerosis and reducing renal function....
The 80th session of the IMO Maritime Environment Protection Committee (MEPC 80) adopted 2023 Strategy on Reduction GHG Emissions from Ships (2023 Strategy), with enhanced targets to tackle harmful emissions. This study strives provide an exact interpretation target and reveal technical requirements therein. Decarbonization were expressed in emission scenarios for specifications. Model calculations parameterizations line reduction principles decarbonizing practices shipping sector avoid...
Homocysteine (Hcy) is an independent risk factor for cardiovascular disease. Monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8) are major chemokines leukocyte trafficking have been identified in atheromatous plaques. MCP-1 IL-8 found to express mainly by macrophages human lesion. We undertook this study determine whether Hcy could induce the secretion of from monocytes and, if so, explore mediating mechanism. that clinically relevant levels (10 1000 micromol/L) increased...