A5043078107- Ovarian function and disorders
- Reproductive System and Pregnancy
- Gut microbiota and health
- Reproductive Biology and Fertility
- Sphingolipid Metabolism and Signaling
- Liver Disease Diagnosis and Treatment
- Endometriosis Research and Treatment
- Metabolism, Diabetes, and Cancer
- Antioxidants, Aging, Portulaca oleracea
- Hair Growth and Disorders
- Drug Transport and Resistance Mechanisms
- Thyroid Disorders and Treatments
- Neuropeptides and Animal Physiology
- Dermatology and Skin Diseases
- Growth Hormone and Insulin-like Growth Factors
- Diabetes Treatment and Management
- Inflammasome and immune disorders
- Ovarian cancer diagnosis and treatment
- Lipid metabolism and disorders
- Pharmacological Effects of Natural Compounds
- Tryptophan and brain disorders
- Chronic Obstructive Pulmonary Disease (COPD) Research
- IL-33, ST2, and ILC Pathways
- Clostridium difficile and Clostridium perfringens research
- Genetics, Aging, and Longevity in Model Organisms
Peking University
2018-2025
Peking University Third Hospital
2019-2025
Ministry of Education of the People's Republic of China
2022-2024
A mechanistic understanding of how microbial proteins affect the host could yield deeper insights into gut microbiota-host cross-talk. We developed an enzyme activity-screening platform to investigate microbiota-derived enzymes might influence physiology. discovered that dipeptidyl peptidase 4 (DPP4) is expressed by specific bacterial taxa microbiota. Microbial DPP4 was able decrease active glucagon like peptide-1 (GLP-1) and disrupt glucose metabolism in mice with a leaky gut. Furthermore,...
Intestinal farnesoid X receptor (FXR) signaling is involved in the development of obesity, fatty liver disease, and type 2 diabetes. However, role intestinal FXR atherosclerosis its potential as a target for clinical treatment have not been explored. The serum levels fibroblast growth factor 19 (FGF19), which encoded by an gene, were much higher patients with hypercholesterolemia than control subjects positively related to circulating ceramide levels, indicating link between FXR, metabolism,...
Polycystic ovary syndrome (PCOS) is a common reproductive endocrine disease in women of age. Ovarian dysfunction including abnormal steroid hormone synthesis and follicular arrest play vital role PCOS pathogenesis. Hyperandrogenemia one the important characteristics PCOS. However, mechanism regulation interaction between hyperandrogenism ovulation abnormalities are not clear. To investigate androgen-related metabolic state granulosa cells patients, we identified transcriptome by RNA-seq....
Calorie restriction (CR) is a dietary intervention used to promote health and longevity1,2. CR causes various metabolic changes in both the production circulation of metabolites1; however, it remains unclear which altered metabolites account for physiological benefits CR. Here we use metabolomics analyse that exhibit abundance during perform subsequent functional validation. We show lithocholic acid (LCA) one alone can recapitulate effects mice. These include activation AMP-activated protein...
The interrelation between hypoxia and immune response has pivotal roles in the pathogenesis of chronic metabolic diseases. However, role macrophage HIF-2α NLRP3 inflammasome activation remains unclear. Here, we show that deficiency macrophages results excessive a manner dependent on CPT1A-mediated enhancement fatty acid oxidation (FAO). Mechanistically, binds directly to Cpt1a promoter is involved regulation H3K27me3 methylation during activation. Myeloid-specific Hif2α knockout mice exhibit...
Abstract Thyroid hormones (TH) regulate systemic glucose metabolism through incompletely understood mechanisms. Here, we show that improved in hypothyroid mice after T3 treatment is accompanied with increased glucagon-like peptide-1 (GLP-1) production and insulin secretion, while co-treatment a GLP-1 receptor antagonist attenuates the effects of on levels. By using lacking hepatic TH β (TRβ) liver-specific TRβ-selective agonist, demonstrate TRβ-mediated signalling required for both...
Polycystic ovary syndrome (PCOS) is a complex involving both endocrine and metabolic disorders. Gut microbiota the intestinal immune factor IL-22 play an important role in pathogenesis of PCOS. However, therapeutic high androgen-induced PCOS mice not clear. We aimed to determine effects on DHEA-induced mouse model explore possible mechanism regulating hyperandrogenism-associated Insulin resistance levels ovarian functions were investigated with or without additional treatment. found that...
Abstract Non-alcoholic steatohepatitis (NASH) is a severe type of the non-alcoholic fatty liver disease (NAFLD). NASH growing global health concern due to its increasing morbidity, lack well-defined biomarkers and clinically effective treatments. Using metabolomic analysis, most significantly changed active lipid sphingosine d18:1 [So(d18:1)] selected from patients. So(d18:1) inhibits macrophage HIF-2α as direct inhibitor promotes inflammatory factors secretion. Male macrophage-specific...
Abstract Polycystic ovary syndrome (PCOS) is a common reproductive endocrine disease, which leads to serious impairment of health in women child-bearing age. Anovulation or oligo-ovulation clinical manifestation PCOS patients. A disturbance the ovarian immune microenvironment contributes disorders follicle development and ovulation; however, underlying mechanism remains unclear. Here we demonstrated protective effect factor interleukin-22 (IL-22) on ovulation. Follicular IL-22 levels were...
Polycystic ovary syndrome (PCOS) is a reproductive endocrine disorder with multiple metabolic abnormalities. Most PCOS patients have concomitant syndromes such as insulin resistance and obesity, which often lead to the development of type II diabetes cardiovascular disease serious consequences. Current treatment symptomatic treatments hormone replacement, has many side effects. Research on its origin pathogenesis urgently needed. Although improving status body can alleviate function in some...
At present, a number of clinical trials have been carried out on GLP-1 receptor agonist liraglutide in the treatment polycystic ovary syndrome (PCOS). However, effect follicle development and its specific mechanism are still unclear.
To investigate the changes in bile acid (BA) metabolites within follicular fluid (FF) of patients with diminished ovarian reserve (DOR) and to identify novel diagnostic markers that could facilitate early detection intervention DOR patients. A total 182 undergoing assisted reproductive technology (ART) were enrolled categorized into normal (NOR) group (n = 91) or measure BA levels FF. granulosa cells (GCs), we collected GCs from an additional 7 groups for transcriptome sequencing....
<title>Abstract</title> Non-alcoholic steatohepatitis (NASH) is a severe type of the non-alcoholic fatty liver disease (NAFLD). NASH growing global health concern due to its increasing morbidity, lack well-defined biomarkers and clinically effective treatments. Using metabolomic analysis, most significantly changed active lipid sphingosine d18:1 [So(d18:1)] was selected from patients. So(d18:1) inhibits macrophage HIF-2α as direct inhibitor promotes activation NLRP3 inflammasome....