A5100651963- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Autophagy in Disease and Therapy
- Regulation of Appetite and Obesity
- Aquaculture Nutrition and Growth
- Thyroid Disorders and Treatments
- Natural Antidiabetic Agents Studies
- Circadian rhythm and melatonin
- Growth Hormone and Insulin-like Growth Factors
- Diet, Metabolism, and Disease
- Crustacean biology and ecology
- Pharmacology and Obesity Treatment
- Genetics, Aging, and Longevity in Model Organisms
- Mitochondrial Function and Pathology
- Cardiovascular Function and Risk Factors
- Cardiovascular and exercise physiology
- Plant Disease Management Techniques
- Congenital gastrointestinal and neural anomalies
- Lipid metabolism and biosynthesis
- Hydrogen's biological and therapeutic effects
- Healthcare Systems and Reforms
- Inflammasome and immune disorders
- Apelin-related biomedical research
- Mercury impact and mitigation studies
- Insect Utilization and Effects
Nanjing Agricultural University
2023-2024
Chengdu University of Traditional Chinese Medicine
2024
Jinan University
2024
Shanghai Ocean University
2024
Guiyang Medical University
2021-2023
Affiliated Hospital of Guizhou Medical University
2021-2023
Shanghai Institute of Nutrition and Health
2021-2023
Shanghai Jiao Tong University
2022-2023
University of Chinese Academy of Sciences
2020-2023
Shaanxi University of Chinese Medicine
2023
The metabolic regulation of cell death is sophisticated. A growing body evidence suggests the existence multiple checkpoints that dictate fate in response to fluctuations. However, whether microRNAs (miRNAs) are able respond stress, reset threshold death, and attempt reestablish homeostasis largely unknown. Here, we show miR-378/378* KO mice cannot maintain normal muscle weight have poor running performance, which accompanied by impaired autophagy, accumulation abnormal mitochondria,...
Abstract Although food availability is a potent synchronizer of the peripheral circadian clock in mammals, underlying mechanisms are unclear. Here, we show that hepatic Bmal1, core transcription activator molecular clock, post-transcriptionally regulated by signals from insulin, an important hormone temporally controlled feeding. Insulin promotes postprandial Akt-mediated Ser42-phosphorylation Bmal1 to induce its dissociation DNA, interaction with 14-3-3 protein and subsequently nuclear...
Abstract Thyroid hormones (TH) regulate systemic glucose metabolism through incompletely understood mechanisms. Here, we show that improved in hypothyroid mice after T3 treatment is accompanied with increased glucagon-like peptide-1 (GLP-1) production and insulin secretion, while co-treatment a GLP-1 receptor antagonist attenuates the effects of on levels. By using lacking hepatic TH β (TRβ) liver-specific TRβ-selective agonist, demonstrate TRβ-mediated signalling required for both...
Abstract The molecular targets and mechanisms of propolis ameliorating metabolic syndrome are not fully understood. Here, we report that Brazilian green reduces fasting blood glucose levels in obese mice by disrupting the formation CREB/CRTC2 transcriptional complex, a key regulator hepatic gluconeogenesis. Using mammalian two-hybrid system based on CREB-CRTC2, identify artepillin C (APC) from as an inhibitor CREB-CRTC2 interaction. Without apparent toxicity, APC protects high fat...
Thyroid hormone (TH) has a profound effect on energy metabolism and systemic homeostasis. Adipose tissues are crucial for maintaining whole-body homeostasis; however, whether TH regulates metabolic homeostasis through its action adipose is unclear. Here, we demonstrate that administration of triiodothyronine (T3), the active form TH, affects both inguinal white tissue (iWAT) metabolism. Taking advantage mouse model lacking adipocyte receptor (TR) α or TRβ, show TRβ major TR isoform mediates...
Alda‑1, an aldehyde dehydrogenase 2 (ALDH2) agonist, has been demonstrated to reduce injury caused by acute myocardial infarction (MI) and ischemia/reperfusion. The present study aimed investigate whether oral administration of Alda‑1 improved long‑term survival rats with chronic heart failure (CHF) post‑MI. MI model treated daily exhibited increase in 20‑week rate compared untreated rats. treatment decreased the weight/body weight ratio, collagen volume, left ventricular (LV) internal...
Physical fatigue is extremely common and occurs daily, considered to be associated with oxidative stress. The diverse functions of deep sea water (DSW) have recently gained increasing attention. Previous studies emphasized the anti‑fatigue effect DSW, but intrinsic mechanism behind remains elucidated. In imprinting control region (ICR) mice model, DSW delayed exhaustive swimming time. addition, decreased area under blood lactate (BLA) curve, which was BLA curve pre‑swimming, post‑swimming...
Dysregulation of cholesterol homeostasis is a major risk factor atherosclerosis, which can lead to serious health problems, including heart attack and stroke. Liver X receptor (LXR) α β are transcription factors belonging the nuclear superfamily, play important roles in homeostasis. Selectively activating LXRβ provides promising strategy for treatment atherosclerosis. Here, we employed atherosclerotic apoE-knockout mice evaluate effects saringosterol, phytosterol with potent selective action...
Carotenoid cleavage oxygenases can cleave carotenoids into a range of biologically important products. isomerooxygenase (NinaB) and β, β-carotene 15, 15'-monooxygenase (BCO1) are two oxygenases. In order to understand the roles that both exert in crustaceans, we first investigated
Introduction Studies on the association between adiponectin and leptin anxiety depression among postmenopausal women are limited. Therefore, present study specifically evaluates mutual relationships in women. Participants design In this cross-sectional study, a total of 190 aged 40–65 years were enrolled. Depression symptoms assessed using Center for Epidemiologic Scale (CES-D), evaluated Hamilton Anxiety Rating (HAM-A). Fasting specimens collected to measure sex hormone, glucose, insulin,...
Iodine is an essential micronutrient for producing thyroid hormone (TH); however, iodide excess can lead to adverse thyroidal effects. Unfortunately, the lack of a proper in vitro model system hampered studies effect on physiology and pathology. Here, we demonstrated that excessive intake downregulated genes related TH synthesis thyroids mice. Since sodium has no these cultured cell lines, developed three-dimensional (3D) culture enable murine thyrocytes form organoids with follicle-like...
Polyethylene glycol loxenatide (PEX-168) is a new antidiabetic drug; as such, there are not yet any reports on its weight loss effect. Therefore, this trial was designed to investigate the effect of PEX-168 simple obese mice.Thirty healthy male C57BL/6 mice were randomly selected and divided into control group (NC) an obesity model group. The high-fat diet-induced (HF) three intervention groups. groups injected with different doses intraperitoneally once week for 12 weeks (low (LD), medium...
Background. At present, there is a lack of drug treatment for obese patients, so it needed to find that effective and has few side effects treat obesity. PEX-168 novel long-acting glucagon-like peptide-1 receptor agonist T2DM. It improves blood glucose with fewer effects. The aim the present study was investigate effect on body weight mice simple Methods. Thirty healthy 6-week-old C57BL/6 male were randomly divided into normal control group (NC, n = 6) obesity model (n 24). high-fat diet...
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Global ecosystems are facing challenges posed by warming and excessive carbon emissions. Urban areas significantly contribute to emissions, highlighting the urgent need improve their ability sequester carbon. While prior studies have primarily examined sequestration benefits of single green or blue spaces, combined impact urban blue–green spaces (UBGSs) on remains underexplored. Meanwhile, rise machine learning provides new possibilities for assessing this nonlinear relationship. We...