A5101772524- DNA Repair Mechanisms
- Traditional Chinese Medicine Analysis
- Cardiac Fibrosis and Remodeling
- Cancer-related Molecular Pathways
- Cancer-related molecular mechanisms research
- Cardiovascular Function and Risk Factors
- Traditional Chinese Medicine Studies
- Pharmacological Effects of Natural Compounds
- Ginseng Biological Effects and Applications
- Ferroptosis and cancer prognosis
- Cancer, Hypoxia, and Metabolism
- Carcinogens and Genotoxicity Assessment
- Cardiac Ischemia and Reperfusion
- Circular RNAs in diseases
- Signaling Pathways in Disease
- Cytokine Signaling Pathways and Interactions
- Protease and Inhibitor Mechanisms
- Medicinal Plant Pharmacodynamics Research
- Genomics, phytochemicals, and oxidative stress
- Mitochondrial Function and Pathology
- Medicinal Plants and Bioactive Compounds
- Angiogenesis and VEGF in Cancer
- Chromatography in Natural Products
- Melanoma and MAPK Pathways
- Dermatology and Skin Diseases
Nanfang Hospital
2009-2025
Southern Medical University
2014-2025
Chongqing Cancer Hospital
2020-2024
Chongqing University
2020-2024
Yunnan Academy of Agricultural Sciences
2024
University of North Carolina at Chapel Hill
2006-2023
First Affiliated Hospital of Guangzhou University of Chinese Medicine
2017-2023
Center for Environmental Health
2006-2023
Dongguan People’s Hospital
2023
Yan'an University
2018
Abstract Head and neck squamous cell carcinomas (HNSCCs) harbor a subset of cells that are CD44(+) present with malignancy radiotherapy resistance. As key regulator self-renewal, Nanog expression not only determines fate in pluripotent but also mediates tumorigenesis cancer cells; thus, we examined the role HNSCC. Three HNSCC lines, tumor xenografts, patient tumors were examined. levels significantly higher spheroids than CD44(−) spheroids, further increased when grown as to enrich for CSCs....
Panax ginseng Meyer (P. ginseng), a herb distributed in Korea, China and Japan, exerts benefits on diverse inflammatory conditions. However, the underlying mechanism active ingredients remains largely unclear. Herein, we aimed to explore of P. against inflammation elucidate mechanisms.Inflammation model was constructed by lipopolysaccharide (LPS) C57BL/6 mice RAW264.7 macrophages. Molecular docking, molecular dynamics, surface plasmon resonance imaging (SPRi) immunofluorescence were utilized...
Vascular smooth muscle cell (VSMC) proliferation and migration play a critical role in the development of arterial remodeling during various vascular diseases including atherosclerosis, hypertension, related diseases. Luteolin is food-derived flavonoid that exerts protective effects on cardiovascular Here, we investigated mechanism luteolin VSMC migration. We found this compound reduced VSMCs, specifically A7r5 HASMC, dose-dependent manner, based MTS, EdU, Transwell, wound healing assays....
Ferroptosis, a new regulated cell death pathway, plays crucial part in the development of cardiovascular disease. However, precise underlying mechanism remains unclear. Therefore, this study aimed to elucidate this.Herein, an erastin-induced H9C2 ferroptosis vitro model and myocardial infarction murine model, which was created by ligating left anterior descending coronary artery, were established. Ferroptosis-related indicators, injury-related Nrf2 signaling-related proteins expression...
Caveolin-1 (Cav-1) is known to participate in many diseases, but its roles alcoholic liver injury remain unknown. In the present study, we aimed explore of Cav-1 protecting hepatocytes from ethanol-mediated nitrosative injury. We hypothesized that could attenuate stress and damage through regulating epidermal growth factor receptor/signal transducer activator transcription 3/inducible nitric oxide synthase (EGFR/STAT3/iNOS)-signaling cascades. Ethanol-fed mice had time- dose-dependent...
Background: Aldehyde dehydrogenase-2 (ALDH2) has a protective effect on ischemic heart disease. Here, we examined the effects of ALDH2 cardiac fibrosis through modulation Wnt/ß-catenin signaling pathway in rat model myocardial infarction (MI). Methods: Wistar rats were divided into sham (control), MI (model), and activator (Alda-1) groups. After 10 days treatment, left ventricular (LV) remodeling parameters each animal evaluated by echocardiography. Myocardial was Masson's trichrome staining...
Cardiovascular disease, a disease caused by many pathogenic factors, is one of the most common causes death worldwide, and oxidative stress plays major role in its pathophysiology. Tanshinone I (Tan I), natural compound with cardiovascular protective effects, main active compounds extracted from Salvia miltiorrhiza . Here, we investigated whether Tan could attenuate stress–induced cardiomyocyte apoptosis through Nrf2/MAPK signaling vivo vitro We found that treatment protected cardiomyocytes...
Panax ginseng has therapeutic effects on various inflammation-related diseases. Ginsenoside Rb3 (GRb3), a natural compound with anti-inflammatory and immunomodulatory properties, is one of the main active panaxadiol extracted from . We explored whether GRb3 inhibited LPS-mediated inflammation through TLR4/NF-κB/MAPK signaling in macrophages. attenuated NO PGE 2 production by attenuating iNOS COX2 expression. also suppressed pro-inflammatory cytokines levels, including IL-1β, IL-6, TNF-α....
Myocardial fibrosis post-myocardial infarction (MI) can induce maladaptive cardiac remodeling as well heart failure. Although 20(S)-ginsenoside Rg3 (Rg3) has been applied to cardiovascular diseases, its efficacy and specific molecular mechanism in myocardial are largely unknown. Herein, we aimed explore whether TGFBR1 signaling was involved Rg3's anti-fibrotic effect post-MI.Left anterior descending (LAD) coronary artery ligation-induced MI mice TGF-β1-stimulated primary fibroblasts (CFs)...
Myocardial fibrosis and inflammation induce adverse cardiac remodeling post-myocardial infarction (MI). Panax ginseng (P. ginseng) is beneficial for diverse cardiovascular diseases. However, the therapeutic effect molecular mechanism underlying are largely unclear. A MI mouse model was constructed through permanent left anterior descending (LAD) coronary artery ligation. Transforming growth factor-β1 (TGF-β1) or lipopolysaccharide (LPS) used stimulating fibroblasts (CFs) RAW264.7 macrophages...
Oxidative stress-induced cardiomyocytes apoptosis is a key pathological process in ischemic heart disease. Glutathione reductase (GR) reduces glutathione disulfide to (GSH) alleviate oxidative stress. Ginsenoside Rb1 (GRb1) prevents the of cardiomyocytes; however, role GR this unclear. Therefore, effects GRb1 on were investigated study. The antiapoptotic evaluated H9C2 cells by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, annexin V/propidium iodide staining, and Western...