A5104159410- Immune Response and Inflammation
- Magnetic properties of thin films
- Ocular Surface and Contact Lens
- Corneal Surgery and Treatments
- Traditional Chinese Medicine Analysis
- Immunotherapy and Immune Responses
- Magnetic Properties and Applications
- Immune Cell Function and Interaction
- Electromagnetic Compatibility and Noise Suppression
- Immune cells in cancer
- Energy Harvesting in Wireless Networks
- Wireless Power Transfer Systems
- Transplantation: Methods and Outcomes
- Bone Tissue Engineering Materials
- Advanced Battery Technologies Research
- Proteoglycans and glycosaminoglycans research
- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Mitochondrial Function and Pathology
- Atherosclerosis and Cardiovascular Diseases
- Phagocytosis and Immune Regulation
- Adipokines, Inflammation, and Metabolic Diseases
- Electrostatic Discharge in Electronics
- Corneal surgery and disorders
- Nanofabrication and Lithography Techniques
Jining Medical University
2025
Guangzhou University of Chinese Medicine
2022-2024
I-Shou University
2023
Zhejiang University
2021
Duke Medical Center
2017-2020
Guangxi University
2020
Jinggangshan University
2020
Duke University
2020
Duke University Hospital
2018-2019
State Grid Corporation of China (China)
2019
The large dv/dt and di/dt outputs of power devices in DC-fed motor drive systems electric vehicles (EVs) always introduce conducted electromagnetic interference (EMI) emissions may lead to system energy transmission losses. effect distributed parameters on EMI from the high voltage EVs is studied. A complete test for direct current fed(DC-fed) alternating (AC) an vehicle (EV) under load conditions set up measure DC cables noise peaks due resonances a frequency range 150 kHz–108 MHz. can...
In this technical note, we describe a facile method for one-step fabrication of paper-based microfluidic devices, by simply using commercially available permanent markers and metal templates with specific patterns. The process involves only single step plotting pattern in paper; it can be typically finished within 1 min. ink marks formed the patterned paper will act as hydrophobic barriers to define hydrophilic flow paths or separate test zones. Various devices created different...
Abstract Osteoinductivity of hydroxyapatite (HA) was investigated using uncommitted pluripotent mouse stem cells, C3H10T1/2 in an vitro differentiation assay. For comparative analysis, the cells were cultured on substrates made osteoinductive HA, with biocompatible titanium and plastics as negative control. HA exhibited ability to induce expression osteo‐specific genes C3H10T1/2, including alkaline phosphatase (ALP), type I collagen, osteocalcin; compared its insignificant up‐regulation same...
PG545 (pixatimod) is a novel immunomodulatory agent, which has been demonstrated to stimulate innate immune responses against tumours in preclinical cancer models. This Phase I study investigated the safety, tolerability, pharmacokinetics, pharmacodynamics and preliminary efficacy of monotherapy. Escalating doses were administered patients with advanced solid malignancies as weekly 1-h intravenous infusion. Twenty-three subjects enrolled across four cohorts (25, 50, 100 150 mg). Three...
Brain death that occurs in the setting of deceased organ donation for transplantation is associated with systemic inflammation unknown origin. It has recently been recognized mitochondria-derived damage-associated molecular patterns (mtDAMPs) released into circulation trauma and tissue injury are a inflammatory response. We examined blood donors found elevated levels cytokines chemokines correlated mtDAMPs. also donor neutrophils activated plasma contains neutrophil-activating factor blocked...
Biomimetic design and substrate-based surface modification of medical implants will help to improve the integration tissue its material interfaces. Surface energy, composition, roughness, topography all influence biological responses implants, such as protein adsorption cell adhesion, proliferation differentiation. In current study, different structures Ti were constructed using facile techniques create various micro-, nano-, nano/micro composite scale topography. We have fabricated three...
The innate immune system is a critical regulator of the adaptive responses that lead to allograft rejection. It increasingly recognized endogenous molecules released from tissue injury and cell death are potent activators immunity. Mitochondria, ancestrally related bacteria, possess an array immune-activating molecules. We have recently demonstrated extracellular mitochondria abundant in circulation deceased organ donors their presence correlates with early dysfunction. Here we demonstrate...
Heparan sulfate (HS) is an essential component of the extracellular matrix (ECM), which serves as a barrier to tumor invasion and metastasis. Heparanase promotes growth by cleaving HS chains proteoglycan releasing HS-bound angiogenic factors facilitates metastasis degrading ECM. mimetics, such PG545, have been developed antitumor agents are designed suppress angiogenesis inhibiting heparanase competing for HS-binding domain factors. However, how PG545 exerts its effect remains incompletely...
Whether complement dysregulation directly contributes to the pathogenesis of peripheral nervous system diseases, including sensory neuropathies, is unclear. We addressed this important question in a mouse model ocular HSV-1 infection, where nerve damage common clinical problem. Through genetic and pharmacologic targeting, we uncovered central role for C3 at morphological functional levels. Interestingly, CD4 T cells were facilitating complement-mediated damage. This same C3/CD4 cell axis...
<h3>Background</h3> Pixatimod (PG545) is a novel clinical-stage immunomodulatory agent capable of inhibiting the infiltration tumor-associated macrophages (TAMs) yet also stimulate dendritic cells (DCs), leading to activation natural killer (NK) cells. Preclinically, pixatimod inhibits heparanase (HPSE) which may be associated with its inhibitory effect on TAMs whereas immunostimulatory activity DCs through MyD88-dependent TLR9 pathway. recently completed Phase Ia monotherapy trial in...
BackgroundWe aim to investigate genes associated with myasthenia gravis (MG), specifically those potentially implicated in the pathogenesis of dilated cardiomyopathy (DCM). Additionally, we seek identify potential biomarkers for diagnosing co-occurring DCM.MethodsWe obtained two expression profiling datasets related DCM and MG from Gene Expression Omnibus (GEO). Subsequently, conducted differential gene analysis weighted co-expression network (WGCNA) on these datasets. The exhibiting common...
<title>Abstract</title> Background Propionic acidemia (PA) is a rare autosomal recessive metabolic disorder caused by defects in propionyl-CoA carboxylase (PCC), mitochondrial enzyme composed of six alpha (PCCA) and beta (PCCB) subunits. Mutations <italic>PCCA/PCCB</italic> genes disrupt PCC function, leading to toxic metabolite accumulation clinical manifestations. Current research limited inadequate patient-derived cellular models ethical constraints sample acquisition. Method Using...
Abstract In solid organ transplantation, cell death arising from ischemia/reperfusion leads to the release of several damage-associated molecular patterns derived mitochondria. Mitochondrial (mtDAMPs) initiate proinflammatory responses, but it remains unknown whether mode affects inflammatory properties Murine and human lines induced selectively undergo apoptosis necroptosis were used examine extracellular mitochondria during programmed death. Mitochondria purified healthy, apoptotic,...
Atherosclerotic (AS) plaques require a dense necrotic core and robust fibrous cap to maintain stability. While previous studies have indicated that the traditional Chinese medicine Huang Lian Jie Du Decoction (HLJDD) possesses capability stabilize AS plaques, underlying mechanisms remain obscure. This study aims delve deeper into potential by which HLJDD improves through an integrated research strategy.
Chronic heart failure (CHF) is a severe consequence of cardiovascular disease, marked by cardiac dysfunction. Jin-Xin-Kang (JXK) traditional Chinese herbal formula used for the treatment CHF. This consists seven medicinal herbs, including Ginseng (Ginseng quinquefolium (L.) Alph.Wood), Astragali Radix (Astragalus membranaceus (Fisch.) Bunge), Salvia miltiorrhiza (Salvia Descurainiae Semen Lepidii (Descurainia sophia Webb ex Prantl), Leonuri Herba (Leonurus japonicus Houtt.), Cinnamomi...
This study evaluated the short-term effects of tofacitinib treatment on peripheral blood leukocyte phenotype and function, reversibility any such following withdrawal in healthy volunteers. Cytomegalovirus (CMV)-seropositive subjects received oral 10 mg twice daily for 4 weeks were followed after drug withdrawal. There slight increases total lymphocyte T-cell counts during treatment, B-cell increased by up to 26%. no significant changes granulocyte or monocyte counts, function. Naïve central...
Atherosclerosis (AS) is the main cause of coronary heart disease, cerebral infarction, and peripheral vascular disease. QingRe HuoXue Formula (QRHXF), a common prescription traditional Chinese medicine, has definite effect on clinical treatment AS, but its mechanism remains to be further explored.
Murine tumor models have been critical to advances in our knowledge of physiology and for the development effective therapies. Essential these studies is ability both track quantify burden
Physiological stimuli such as thrombin, or pathological lysophosphatidic acid (LPA), activate platelets. The activated platelets bind to monocytes through P-selectin-PSGL-1 interactions but also release the contents of their granules, commonly called "platelet releasate". It is known that in contact with platelet releasate produce reactive oxygen species (ROS). Reversible cysteine oxidation by ROS considered be a potential regulator protein function. In previous study, we used THP-1...
Atherosclerosis (AS) and Non-alcoholic fatty liver disease (NAFLD) are chronic metabolic disorders with high prevalence significant health impacts. Both conditions share common pathophysiological pathways including abnormal lipid metabolism inflammation. Berberine (BBR), an isoquinoline alkaloid, is known for its beneficial effects on various cardiovascular disorders. This study investigates BBR’s impact AS NAFLD through bioinformatics analysis experimental models. utilized methods,...
3083 Background: PG545 (pixatimod, pINN) is a novel immunomodulatory agent which stimulates dendritic cells (DC) via TLR9/IL-12 pathway to activate natural killer (NK) cells. It also inhibits tumour-associated macrophages in cancer models. We report on safety, PK, PD, and antitumor activity of monotherapy. Methods: In this dose escalation (3+3 design) study, eligible pts (ECOG≤1) with advanced solid malignancies who failed standard therapies received once weekly as 1-hour i.v. infusion until...