A5100358454- Animal Virus Infections Studies
- Viral Infections and Immunology Research
- Viral gastroenteritis research and epidemiology
- Liver Disease Diagnosis and Treatment
- Pancreatic function and diabetes
- Acute Kidney Injury Research
- Acute Myocardial Infarction Research
- Cardiac Arrest and Resuscitation
- Viral Infections and Vectors
- Osteoarthritis Treatment and Mechanisms
- Aortic aneurysm repair treatments
- Tuberculosis Research and Epidemiology
- Hepatitis C virus research
- Influenza Virus Research Studies
- Traditional Chinese Medicine Studies
- Diabetic Foot Ulcer Assessment and Management
- Animal Disease Management and Epidemiology
- Traditional Chinese Medicine Analysis
- Chronic Kidney Disease and Diabetes
- Medical Research and Treatments
- Viral Infections and Outbreaks Research
- Infectious Diseases and Tuberculosis
- Adipose Tissue and Metabolism
- Hormonal and reproductive studies
- Hepatitis B Virus Studies
Southwest Medical University
2024-2025
Hunan Province Chest Hospital
2025
Hefei Institutes of Physical Science
2024
Chinese Academy of Sciences
2017-2024
Capital Medical University
2017-2024
Guangdong Academy of Medical Sciences
2010-2024
Southern Medical University
2018-2024
Guangdong Provincial People's Hospital
2002-2024
Hangzhou Hospital of Traditional Chinese Medicine
2009-2024
Stomatology Hospital
2024
Abstract Bone marrow stimulation is performed using several surgical techniques that have not been systematically compared or optimized for a desired cartilage repair outcome. In this study, we investigated acute osteochondral characteristics following microfracture and comparing to drilling in mature rabbit model of repair. Microfracture holes were made depth 2 mm drill either 6 under cooled irrigation. Animals sacrificed 1 day postoperatively subchondral bone assessed by histology...
We investigated an outbreak of severe fever with thrombocytopenia syndrome (SFTS) that occurred during May and June 2010, to identify the mode transmission. Contact index patient's blood was significantly associated development SFTS (P = .01, by χ(2) test for linear trend); frequency contact increased risk in a dose-response manner .03, trend). concluded human-to-human transmission caused this cluster cases.
Subchondral drilling and microfracture are bone marrow stimulation techniques commonly used for the treatment of cartilage defects. Few studies to date have examined technical variants which may influence success repair procedures. This study compared effect hole depth (6 mm vs. 2 mm) type (drill microfracture) on chondral defect using a mature rabbit model. Results from quantitative histomorphometry histological scoring showed that deeper versus shallower elicited greater fill with more...
The G-protein coupled receptor 55 (GPR55) is activated by lysophosphatidylinositols and some cannabinoids. Recent studies found prominent roles for GPR55 in neuropathic/inflammatory pain, cancer bone physiology. However, little known about the role of CNS development function. To address this question, we performed a detailed characterization knockout mice using molecular, anatomical, electrophysiological, behavioral assays. Quantitative PCR that mRNA was expressed (in order decreasing...
Background Microfracture and drilling are bone marrow–stimulation techniques that initiate cartilage repair by providing access to cell populations in subchondral marrow. This study examined the effect of hole depth microfracture versus on full-thickness chondral defects. Hypotheses Repaired does not reconstitute its native structure exhibits atypical morphologic features. Drilling deeper induces greater remodeling is related improved repair. Study Design Controlled laboratory study. Methods...
The European Society for Clinical Nutrition and Metabolism (ESPEN) guidelines recommend the Royal Free Hospital-Nutritional Prioritizing Tool (RFH-NPT) to identify malnutrition risk in patients with liver disease. However, little is known about application of RFH-NPT screen China, where primarily suffer from hepatitis virus-related cirrhosis. A total 155 cirrhosis without cancer or uncontrolled co-morbid illness were enrolled this prospective study. We administered Nutritional Risk Screening...
Background Despite the obvious advantages of metagenomic next-generation sequencing (mNGS) in etiological diagnosis various infectious diseases, there are few reports on suspected thoracic and abdominal infections patients with end-stage liver disease (ESLD). Methods Seventy-three ESLD were enrolled from January 2019 to May 2021 due complicated poor response empirical anti-infective treatment. Pleural effusion ascites samples these collected for mNGS detection conventional pathogen culture....
The genipin cross-linked alginate-chitosan (GCAC) microcapsule, composed of an alginate core and a chitosan membrane, was recently proposed for live cell encapsulation other delivery applications. This article the first time describes details microcapsule membrane characterization using noninvasive in situ method without any physical or chemical modifications on samples. Results showed that cross-linking reaction generated fluorescent chitosan-genipin conjugates. clearly visualized by...
The Mesozoic iron oxide-copper-gold (IOCG) subprovince of littoral south-central Peru, centered at latitude 15°11′ S, longitude 75°6′ W, incorporates Marcona, the preeminent central Andean oxide deposit (1.9 Gt@ 55.4% Fe), and Mina Justa, one few major IOCG deposits with economic copper grades (346.6 Mt @ 0.71% Cu). emplacement magnetite orebodies uneconomic Cu (avg 0.12%) Marcona was controlled by northeast-striking faults transecting an active andesitic-dacitic, shallow-marine Middle...
Circulating tumor cells (CTCs) detection, enumeration and characterization with microfluidic chips has critical significance in cancer prognosis offering a non-invasive "liquid biopsy". Based on physical differences of size deformability, we explore micro-ellipse filters consisting microfuidic slits series gradually narrowed. Slender tunnels sensitively capture slim chance to escape. Tumor could reside at sites organized by arrays microposts enduring less stress. Circular elliptical...
Objective: Individuals with both hypertension and diabetes have been confirmed to significantly increase the risk of cardiovascular disease morbidity mortality compared those only or diabetes. This study aimed evaluate potential different anthropometric indices for predicting among hypertensive patients. Methods: The group consisted 6,990 adults without who were recruited in China. Demographic clinical assessment, physical examinations, laboratory tests, measurements, including body mass...
Objective Gut microbiota and its metabolites have regulatory effects on PCOS related ovarian dysfunction insulin resistance. Escherichia coli Nissle 1917 (EcN) is a genetically controlled probiotic with an excellent human safety record for improving gut microbiome metabolic disorders immune system disorders. Here we focused to explore the application effect of EcN microbiota-metabolism-IL-22-mitochondrial damage axis in PCOS. Methods mice were constructed dehydroepiandrosterone (DHEA)...
Abstract Background Luteolin (3,4,5,7-tetrahydroxy flavone) is reported to strongly protect from acute carbon tetrachloride (CCl 4 ) -induced liver injury or fibrosis. Ferroptosis can be induced by hepatic injury, and contributes fibrosis development. The exact functional mechanism underlying luteolin inhibition of whether ferroptosis involved are unclear. Methods Mice model cell were constructed explore the effect molecular mechanisms in treatment using CCl4. Cell Counting Kit-8 (CCK-8)...
Tuberculous meningitis (TBM) is the most serious type of tuberculosis infection, and there a lack accurate diagnostic targets for TBM. Therefore, it great clinical public health significance to find specific target early diagnosis prediction prognosis From January 2021 February 2024, 110 TBM patients 122 with non-tumor, non-infectious headaches were admitted Hunan Chest Hospital. To compare two groups, cerebrospinal fluid (CSF) levels sCD163 MMP-9, as well serum NCAM1 protein levels,...
The high recurrence rate of denture stomatitis may be related to the strong resistance fungi. Therefore, method providing biomaterials with antifungal properties is an attractive solution for improving microbial control. Against drug Candida albicans, this study aim elucidate photocatalytic antibacterial effect TiO2-HAP nanocomposite-modified PMMA on albicans through in vitro experiments, and evaluate potential impact mechanical properties, optical cytotoxicity contact angle modified PMMA,...
Microencapsulation is an emerging technology in the development of bioartificial organs for drug, protein, and delivery systems. One advancements establishing appropriate membrane material live cell tissue encapsulation incorporation poly(ethylene glycol) (PEG) to widely studied alginate microcapsules. The current study investigates properties integrating PEG microcapsules coated with poly-l-lysine (PLL) chitosan as well a novel microcapsule which combines both PLL chitosan. Results show...
Marcona, the preeminent Andean magnetite deposit (1.9 Gt @ 55.4% Fe and 0.12% Cu), is located in iron oxide copper-gold (IOCG) subprovince of littoral south-central Peru. Cu (-Zn-Pb) sulfide mineralization was controlled by northeast-striking faults transecting a Middle Jurassic (Aalenian-to-Oxfordian) andesitic, shallow-marine arc succession contiguous, plate boundary-parallel, Late to mid-Cretaceous volcanosedimentary basins. At hydrothermal activity initiated earliest (161–177 Ma)...
Background Diabetes has been regarded as an inflammatory condition which is associated with left ventricular diastolic dysfunction (LVDD). The purpose of this study was to examine the expression levels macrophage migration inhibitory factor (MIF) and G protein-coupled receptor kinase 2 (GRK2) in patients early diabetic cardiomyopathy, investigate mechanisms involved MIF GRK2 activation. Methods 83 age range 30-64 years type diabetes 30 matched healthy men were recruited. Left function...