A5109354569- Multiple Myeloma Research and Treatments
- Sleep and Wakefulness Research
- Sleep and related disorders
- Vagus Nerve Stimulation Research
- Erythrocyte Function and Pathophysiology
- Hemoglobin structure and function
- Peptidase Inhibition and Analysis
- Effects and risks of endocrine disrupting chemicals
- Nematode management and characterization studies
- Acupuncture Treatment Research Studies
- Traditional Chinese Medicine Studies
- Monoclonal and Polyclonal Antibodies Research
- Cassava research and cyanide
- Heart Rate Variability and Autonomic Control
- Anesthesia and Sedative Agents
- Aluminum toxicity and tolerance in plants and animals
- Vascular Malformations and Hemangiomas
- Cardiac, Anesthesia and Surgical Outcomes
- Pressure Ulcer Prevention and Management
- Protein Degradation and Inhibitors
- Music Therapy and Health
- Pluripotent Stem Cells Research
- Nausea and vomiting management
- Autoimmune and Inflammatory Disorders
- Protein Interaction Studies and Fluorescence Analysis
First Affiliated Hospital of Guangzhou University of Chinese Medicine
2021-2025
Mayo Clinic Hospital
2024-2025
Wuhan Third Hospital
2012-2024
Wuhan Institute of Physics and Mathematics
2024
Huazhong University of Science and Technology
2024
Wuhan National Laboratory for Optoelectronics
2024
Chinese Academy of Sciences
2024
Wuhan University
2024
Tongren Hospital
2024
University of Hong Kong - Shenzhen Hospital
2024
Red blood cells (RBCs) during microcirculation, aging and storage, lose N-acetylneuraminic acid (NANA) other biomaterials thereby altering cell structures, some properties functions. Such damage very likely underlies the serious adverse effects of transfusion. However, a controversy has remained since 1961–1977 as to whether with aging, RBCs, suffering loss NANA, do have decreased charge density. Any correlation between changes in is also not clear. Therefore, remove ambiguity uncertainty,...
Abstract Background Neonatal hypoxic-ischemic encephalopathy (HIE) is one of the most common neurological problems occurring in perinatal period. However, there still not a promising approach to reduce long-term neurodevelopmental outcomes HIE. Recently, itaconate has been found exhibit anti-oxidative and anti-inflammatory effects. therapeutic efficacy HIE remains inconclusive. Therefore, this study attempts explore pathophysiological mechanisms oxidative stress inflammatory responses as...
Transcutaneous vagus nerve stimulation (tVNS), a non-invasive method of brain through the auricular branch nerve, has shown promising results in treating major depressive disorder (MDD) several pilot studies. However, neural mechanism by which effect on depression might be achieved not been fully investigated, with only few neuroimaging studies demonstrating tVNS-induced changes brains healthy volunteers. Identifying specific pathways, are influenced tVNS compared sham depressed individuals,...
In Alzheimer's disease, hypochlorous acid involved in the clearance of invading bacteria or pathogens and butyrylcholinesterase engaged hydrolysis neurotransmitter acetylcholine are relatively significantly altered. However, there few dual detection probes for butyrylcholinesterase. addition, single-response suffer from serious off-target effects near-infrared do not easily penetrate blood–brain barrier due to their excessive molecular weight. this work, we constructed a two-photon...
Objective Gut microbiota and its metabolites have regulatory effects on PCOS related ovarian dysfunction insulin resistance. Escherichia coli Nissle 1917 (EcN) is a genetically controlled probiotic with an excellent human safety record for improving gut microbiome metabolic disorders immune system disorders. Here we focused to explore the application effect of EcN microbiota-metabolism-IL-22-mitochondrial damage axis in PCOS. Methods mice were constructed dehydroepiandrosterone (DHEA)...
Hemoglobin dissociation is of great interest in protein process and clinical medicine as well artificial blood research. However, the pathway mechanisms pH-dependent human Hb are not clear, whether would really dissociate into monomers still a question. Therefore, we have conducted multi-technique investigation on structure function versus pH. Here demonstrate that tetramer hemoglobin can easily dimer abnormal pH → reversible if returns to normal physiological value. When environmental...
Abstract Membrane sialic acid ( SA ) plays an important role in the survival of red blood cells RBC s), age‐related reduction content negatively impacts both structure and function these cells. We have therefore suggested that remodelling membrane aged would help recover cellular functions characteristic young s. developed effective method for re‐sialylation s by which were incubated with presence cytidine triphosphate (CTP) α‐2,3‐sialytransferase. found could be re‐sialylated if they had...
Insomnia inflicts mental burden and decreases physical productivity affects life quality. Transcutaneous vagus nerve stimulation (ta‐VNS) may be an effective treatment option for insomnia. This study aims to evaluate the effect safety of ta‐VNS compare it with transcutaneous nonvagus (tn‐VNS). A multicenter, randomized, clinical trial was conducted at 3 hospitals in China enrolling 72 insomnia participants from May 2016 June 2017. Participants were randomly assigned (1 : 1) receive 40...
Depression and pain disorders share a high degree of comorbidity. Inflammatory mechanisms play an important role in the pathogenesis depression-chronic somatic In this study, we investigated effects acupuncture on blood brain regional tumor necrosis factor alpha (TNF-α) rats with depression chronic Forty Sprague-Dawley were randomly divided into following 4 groups 10 each: control, model, model treated transcutaneous auricular vagus nerve stimulation (taVNS), electroacupuncture (EA). Chronic...
Nitroreductase (NTR) is an enzyme that upregulated under tumor-depleted oxygen conditions. The majority of studies have been conducted on NTR, but many existing fluorescent imaging tools for monitoring NTR inevitably suffer from weak targeting, low sensitivity, and simple tumor models. Research diagnosing lung tumors has very popular in recent years, targeting assays orthotopic still great research value, as such models better mimic the reality cancer organism. Here, we developed a novel...
Sweet syndrome (SS), which is characterised by fever and erythematous tender skin lesions, has been shown to be associated with lymphoma. However, there are limited reported experiences on the wound care of SS in patients This case report presents a patient anaplastic lymphoma kinase (ALK)-positive large cell (ALK+ALCL). A 42-year-old male was referred The First Affiliated Hospital Guangzhou University Chinese Medicine redness pain left shoulder abdomen following chemotherapy for ALK+ALCL...
428 Background: Prostate cancer management presents a significant healthcare burden, with the need to efficiently triage patients for treatment. Our objective is leverage large language models predict physician-recommended treatment plans from unstructured clinical notes. By accurately predicting plans, we aim risk stratify and effectively, thereby optimizing allocation of physician resources. Methods: 448 initial urology consultation patient notes following first positive prostate biopsy...
A thin endometrium can lead to low clinical pregnancy rates, live birth high spontaneous abortion and weight. However, current methods of treating endometria do not achieve ideal results. This study explored the effect Indian Hedgehog (IHH) on its mechanism action. endometrial rat model was established by infusion 95% ethanol. IHH overexpressed in rats using adeno-associated viruses. The thickness number glands vessels were determined H&E staining. Endometrial fibrosis detected Masson's...
Intravenous daratumumab is approved for the treatment of multiple myeloma. In Part 1 PAVO study, a mix-and-deliver subcutaneous formulation with recombinant human hyaluronidase PH20 (rHuPH20) was well tolerated, low rates infusion-related reactions and similar efficacy to intravenous daratumumab. 2 evaluated concentrated, pre-mixed co-formulation rHuPH20 (DARA SC). Patients ≥2 prior lines therapy, including proteasome inhibitor immunomodulatory drug, received (1800 mg) (30,000 U) in 15 mL...
Abstract In this work, we present our strategy for developing domain-specific large language models which cover the vocabulary of target domain and train on reliable sources clinical information. Prostate cancer was chosen as a use-case study. We collected more than 1.8 million notes radiology pathology reports 15341 patients treated prostate in Mayo Clinic across three sites outpatient clinics. addition to training data, built tokenizers devised knowledge-guided strategies LLM development....
Purpose: To explore the correlation between community-acquired pressure injury (CAPI) and comorbidities in elderly patients with emergency admission. Patients Methods: aged 65 years or above were enrolled from multiple departments, such as Internal Medicine, Surgery, Geriatrics, Intensive Care Unit of Wuhan Third Hospital, which is affiliated to University, January December 2020. Comorbidity data extracted using 10th edition International Classification Diseases (ICD-10) hospital electronic...
Abstract Raman confocal microscopy, including the techniques of point spectra, line mapping, 2D and time‐dependent spectrum monitoring performed with 514.5 nm excitation light, was used in a comparative study on distribution oxidation states hemoglobin (Hb) young old mature erythrocytes. It is demonstrated that contrast to homogeneous Hb cells, there are more around cell membrane erythrocyte. The proteins exhibit some extent aggregation conformational change, present less ability oxidation,...
To observe and evaluate the clinical efficacy of transcutaneous vagus nerve stimulation (taVNS) at auricular concha for primary insomnia (PI) affective disorder.A total 35 patients who met diagnosis standard PI in Diagnostic statistical manual mental disorders (5th edition) were included. The self-developed stimulator (TENS-200A) was applied concha, 30 min per treatment, twice a day, 5 days week consecutive 4 weeks. follow-up visit conducted end 6th week. Pittsburg sleep quality index scale...