A5101572597- Traditional Chinese Medicine Analysis
- Phytochemistry and Bioactive Compounds
- Pharmacological Effects of Natural Compounds
- Natural product bioactivities and synthesis
- Cancer therapeutics and mechanisms
- Cancer Treatment and Pharmacology
- Pharmacogenetics and Drug Metabolism
- Phytochemicals and Antioxidant Activities
- Bioactive natural compounds
- Chromatography in Natural Products
- Flavonoids in Medical Research
- Polysaccharides and Plant Cell Walls
- Phytochemistry and biological activities of Ficus species
- Cancer, Lipids, and Metabolism
- Nitric Oxide and Endothelin Effects
- Metal complexes synthesis and properties
- Phytochemistry and Biological Activities
- Helicobacter pylori-related gastroenterology studies
- Cancer Mechanisms and Therapy
- Neuroscience and Neuropharmacology Research
- Bioactive Compounds and Antitumor Agents
- Asthma and respiratory diseases
- Neurological Disease Mechanisms and Treatments
- Metabolomics and Mass Spectrometry Studies
- Piperaceae Chemical and Biological Studies
Guiyang Medical University
2016-2025
Affiliated Hospital of Liaoning University of Traditional Chinese Medicine
2024
General Hospital of Shenyang Military Region
2022
China Medical University
2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2017
State Administration of Traditional Chinese Medicine of the People's Republic of China
2017
Nanyang Medical College
2014
In Alzheimer's disease, hypochlorous acid involved in the clearance of invading bacteria or pathogens and butyrylcholinesterase engaged hydrolysis neurotransmitter acetylcholine are relatively significantly altered. However, there few dual detection probes for butyrylcholinesterase. addition, single-response suffer from serious off-target effects near-infrared do not easily penetrate blood–brain barrier due to their excessive molecular weight. this work, we constructed a two-photon...
To examine the relations between social support, illness uncertainty (IU), and fear of cancer recurrence (FCR).Using data from a convenience sample 231 breast survivors in China to perform structural equation modeling with bootstrapping estimation. Participants were recruited general hospital Shenyang, China. completed Perceived Social Support Scale, Mishel Uncertainty Illness Fear Cancer Recurrence Inventory- Shorter Form.The majority have FCR (67.5%). was significantly negatively...
ABSTRACT Gerbera piloselloides Herba (GP) is a traditional herb commonly used for asthma in China. Our previous studies have identified key group of active components—arbutin, marmesin, and luteolin—that demonstrate significant efficacy treatment, showing promising therapeutic potential. Although we previously investigated the comparative pharmacokinetics (only absorption process) 11 main components GP both control asthmatic mice, these 3 compounds, including absorption, metabolism,...
Fear extinction forms a new memory but does not erase the original fear memory. Exposure to novelty facilitates transfer of short-term long-lasting However, underlying cellular and molecular mechanisms are still unclear. Using classical contextual fear-conditioning model, we investigated effect on in rats. We found that exposure novel environment familiar 1 h before or after enhanced long-term (LTM) reduced reinstatement. exploring 6 had no such effect. Infusion β-adrenergic receptor (βAR)...
Heart failure (HF) is the advanced heart disease with high morbidity and mortality. Compound DanShen Dripping Pill (CDDP) a widely used Traditional Chinese Medicine for cardiovascular treatment. Herein, we investigated if CDDP can protect mice against doxorubicin (DOX) or isoprenaline (ISO)-induced HF. After 3 days feeding of normal chow containing CDDP, were started DOX ISO treatment 4 weeks 18 days. At end treatment, conducted electrocardiogram echocardiographic test. Blood samples...
Shenxiong glucose injection (SGI), a traditional Chinese medicine (TCM) preparation, has been widely used for the treatment of various cardiovascular and cerebrovascular diseases many years. We assessed potential influences SGI on activities six CYP enzymes (CYP1A2, CYP2C11, CYP2C19, CYP2D4, CYP2E1, CYP3A2) pharmacokinetics warfarin in rats. compared plasma probe drugs (caffeine/CYP1A2, tolbutamide/CYP2C11, omeprazole/CYP2C19, metoprolol/CYP2D4, chlorzoxazone/CYP2E1, midazolam/CYP3A2)...
Gerberae Piloselloidis Herba is widely used to treat cough and asthma in China. However, its effects on allergic as related chemical compositions have not been fully elucidated, there a scarcity of methods determine multi-component contents for quality control. In this study, protective ovalbumin-induced models were investigated, while qualitative quantitative analyses multiple constituents conducted by using an ultrahigh-performance liquid chromatography-Q Exactive hybrid...
Background: Shenxiong Glucose Injection (SGI) is a traditional Chinese medicine formula composed of ligustrazine hydrochloride and Danshen (Radix et rhizoma Salviae miltiorrhizae ; Salvia miltiorrhiza Bunge, Lamiaceae). Our previous studies others have shown that SGI has excellent therapeutic effects on myocardial ischemia (MI). However, the potential mechanisms action yet to be elucidated. This study aimed explore molecular mechanism in MI treatment. Methods: Sprague-Dawley rats were...
Although Polygonum orientale L. (PO) has a beneficial effect on treatment of myocardial ischemia (MI), its mechanism remains unclear. This study aimed to explore the pharmacological PO against MI through MAPK signaling pathways. Firstly, therapeutic was evaluated for mice. Using Western blot and immunohistochemistry, influence pathways cell apoptosis investigated. Subsequently, one key pathway (ERK) screened out, which posed most obvious impact. Finally, an inhibitor ERK1/2 utilized further...
Introduction:Cynanchum auriculatum (CA) is usually used to treat digestive disorders, such as anorexia, enteritis, dysentery, and indigestion. Functional dyspepsia (FD) characterized by a group of symptoms associated with the gastroduodenal region. Recent pharmacological studies have demonstrated efficacy CA for treating FD. However, pharmacokinetics (PK) tissue distribution in physiological FD states still unclear. The present study aimed clarify differences PK parameters four major active...
L. (PO) has demonstrated notable efficacy in treating coronary heart disease. Previous research identified eight key active components PO for cardiomyocyte protection, but the underlying mechanisms remained unclear; Methods: Network pharmacology and molecular docking were used to identify potential target proteins of PO's components. Experimental models assessed cardioprotective effects mechanisms; Results: analysis revealed that exhibited highest binding affinity with SOD2, indicating it as...
Abstract Copper-induced death, also termed cuproptosis, is a novel form of programmed cell death and promising as new strategy for cancer therapeutics. Elevated copper levels in tumor cells are positively associated with high PD-L1 expression. Nonetheless, the prognostic significance cuproptosis-related immune checkpoint genes (CRICGs) hepatocellular carcinoma remains to be further clarified. This study aimed construct CRICG signature predict immunotherapy response outcomes HCC patients. The...
Hepatocellular carcinoma (HCC) is a malignancy of liver cells. Recent studies have shown that HCC patients often changes in the activities transporters and metabolic enzymes, which can considerably affect drug pharmacokinetics lead to toxicity. Doxorubicin (DOX) has been frequently administered chemotherapy for HCC, but our knowledge, effects on DOX are unknown.In present study, following intravenous administration diethylnitrosamine-induced rats, plasma concentration was determined by...
Aidi Injection (ADI), a Chinese herbal preparation with anti-cancer activity, is used for the treatment of hepatocellular carcinoma (HCC). Several clinical studies have shown that co-administration ADI doxorubicin (DOX) associated reduced toxicity chemotherapy, enhanced efficacy and improved quality life patients. However, limited information available about herb-drug interactions between DOX. The study aimed to investigate pharmacokinetic mechanism DOX in rat model HCC.
Gerberae Piloselloidis Herba, a traditional Chinese medicine, is often employed to treat such lung-related diseases as coughs, asthma, and pulmonary carbuncles in southwest China. Our previous study demonstrated that its active fraction, prepared from exerts an obvious beneficial effect on asthma. However, the pharmacokinetics of major constituents remain unclear. Therefore, ultra-performance mass spectrometry-electrospray ionization-tandem spectrometry method was successfully established...
Three new acenaphthene derivatives cis-3-(4'-methoxyphenyl)-acenaphthene-1, 2-diol (1), trans-(1S, 2S)-3-phenyl-acenaphthene-1, (2) and 8-(4-hydroxyphenyl)-2H-acenaphthylen-1-one (3) in company with six known compounds were isolated from the 70% ethanol extract of rhizomes Musa basjoo. Those chemical constituents separated purified by macroreticular resin, silica gel, Toyopearl HW-40F, SephadexLH-20 other chromatographic methods, respectively. The structures elucidated HR-ESI-MS, 1H NMR, 13C...