Le Sun

ORCID: 0000-0001-7548-399X
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About
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Research Areas
  • Gut microbiota and health
  • Protein Kinase Regulation and GTPase Signaling
  • Sperm and Testicular Function
  • Cancer, Lipids, and Metabolism
  • Inflammatory mediators and NSAID effects
  • Reproductive Physiology in Livestock
  • Receptor Mechanisms and Signaling
  • Drug Transport and Resistance Mechanisms
  • RNA modifications and cancer
  • Pediatric Hepatobiliary Diseases and Treatments
  • Cloud Computing and Resource Management
  • Peer-to-Peer Network Technologies
  • Coagulation, Bradykinin, Polyphosphates, and Angioedema
  • Growth Hormone and Insulin-like Growth Factors
  • Birth, Development, and Health
  • Reproductive Biology and Fertility
  • Protease and Inhibitor Mechanisms
  • Tryptophan and brain disorders
  • Cellular transport and secretion
  • Parasites and Host Interactions
  • TGF-β signaling in diseases
  • Cell Adhesion Molecules Research
  • Ginseng Biological Effects and Applications
  • Protein Hydrolysis and Bioactive Peptides
  • Regulation of Appetite and Obesity

Guangxi University
2021-2025

Guangzhou University of Chinese Medicine
2023

State Key Laboratory For Conservation and Utilization of Subtropical Agro-Bioresources
2021-2022

Kunming Medical University
2022

Jimei University
2019

PLA Electronic Engineering Institute
2011

W. Alton Jones Cell Science Center
1987-1993

Ginsenoside Rg1 is the active ingredient of plant named genus Panax (ginseng), which exhibited significant bioactivities, including anti-inflammatory, antioxidation, and anti-diabetic effects. Herein, 4-week treatment ginsenoside remarkably decreased blood glucose levels improved resistance insulin, oxidative stress, inflammation along with lipid profile in T2D rats triggered via high-fat diet streptozotocin (STZ). supplementation intestinal microbial composition induced by type 2 diabetes...

10.1111/jfbc.14321 article EN Journal of Food Biochemistry 2022-07-19

In the cloned rat thymic endocrine epithelial cell line TEA3A1, treatment with dexamethasone leads to decreased levels of prostaglandin E2, F2 alpha, and thromboxane B2. Dexamethasone also a decrease both calcium-dependent calcium-independent phospholipase A2 activity measured in cell-free assay. Dexamethasone-treated cells have increased lipocortin-I, putative modulator activity. The property binding lipocortin particulate fraction was used prepare cytosolic subcellular fractions which...

10.1042/bj2610395 article EN Biochemical Journal 1989-07-15

Follicular atresia is one of the main factors limiting reproductive power domestic animals. At present, molecular mechanisms involved in porcine follicular at metabolic level remain unclear. In this study, we divided follicles Bama Xiang pigs into healthy (HFs) and atretic (AFs) based on follicle morphology. The expression genes related to granulosa cells (GCs) concentration hormones fluid (FF) from HFs AFs were detected. We then used liquid chromatography–mass spectrometry-based...

10.3389/fvets.2021.679947 article EN cc-by Frontiers in Veterinary Science 2021-07-26

High-quality semen with high viability is critical to improving the in-vitro fertilization efficiency. This study aimed understand effect of ambient temperature and humidity on quality seminal plasma biochemical parameters Mediterranean buffalo in March July. The metabolites two seasons were detected using UPLC-MS/MS method. results showed that index (THI) 66.86 ± 2.98, 82.94 3.52 Compared March, breath frequency, rectal temperature, heat shock protein 70 expressions significantly increased...

10.1080/10495398.2022.2056045 article EN Animal Biotechnology 2022-03-30

The stimulation of both phospholipase A2 (PLA2) enzymic activity and the production prostaglandin E2 (PGE2) by transforming growth factor-alpha (TGF-alpha) Ca2+ ionophore A23187 in TEA3A1 rat thymic epithelial cells were studied. TGF-alpha itself at various concentrations (5-200 ng/ml) had no effect on PGE2 production. (1 microgram/ml) stimulated average 18-fold over control. When (50 was added to presence A23187, a synergistic (on 45-fold) observed. Synergistic also observed level...

10.1042/bj2930109 article EN Biochemical Journal 1993-07-01

Using TEA3A1 rat endocrine thymic epithelial cells, we demonstrated that kallikrein (EC 3.4.21.35) not only stimulated the release of arachidonic acid (AA) and its metabolites from cells but also enhanced intracellular synthesis prostaglandin E2 (PGE2) thromboxane B2 (TXB2) by approx. 2-fold. The stimulatory effect was dose- time-dependent could be blocked aprotinin, a inhibitor. It found phospholipase A inhibitors ONO RS082 [2-(p-amylcinnamoyl)amino-4-chlorobenzoic acid], mepacrine...

10.1042/bj2580351 article EN Biochemical Journal 1989-03-01

10.1016/0006-291x(87)90919-3 article EN Biochemical and Biophysical Research Communications 1987-10-01

Churn is a great challenge for the development and deployment of Distributed Hash Table networks, but current churn treatments ignore effect adapting size routing table flexibly to handle churn. In this paper, we research self-adaptive mechanism Kademlia. Based on quantifying influence K , parameter representing k -bucket, performance, algorithm proposed. This adapts variation rate which estimated by validity data in table. Simulation results show that it can reduce lookup latency under Even...

10.4028/www.scientific.net/amr.255-260.2121 article EN Advanced materials research 2011-05-01
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