A5073765005- Myasthenia Gravis and Thymoma
- Peripheral Neuropathies and Disorders
- Muscle Physiology and Disorders
- MicroRNA in disease regulation
- Cardiomyopathy and Myosin Studies
- Multiple Sclerosis Research Studies
- Cancer-related molecular mechanisms research
- Monoclonal and Polyclonal Antibodies Research
- Circular RNAs in diseases
- Autoimmune Neurological Disorders and Treatments
- Kidney Stones and Urolithiasis Treatments
- Antifungal resistance and susceptibility
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenetic and Muscular Disorders Research
- Polyomavirus and related diseases
- T-cell and B-cell Immunology
- Pediatric Urology and Nephrology Studies
- Genetic Neurodegenerative Diseases
- Parkinson's Disease and Spinal Disorders
- Immunotherapy and Immune Responses
- Inflammatory Myopathies and Dermatomyositis
- Hippo pathway signaling and YAP/TAZ
- Neuroblastoma Research and Treatments
- Computational Drug Discovery Methods
- Tryptophan and brain disorders
Xiangya Hospital Central South University
2016-2025
Central South University
2016-2025
Ningxia Medical University General Hospital
2025
Ningxia Medical University
2022-2025
University of South China
2021-2025
University of Iowa
2025
Chongqing University of Posts and Telecommunications
2024
Shanghai Cell Therapy Research Institute
2024
Tongji Hospital
2015-2024
Huazhong University of Science and Technology
2015-2024
The traditional Chinese Medicine (TCM) herbal formula Lian Hua Qing Wen (LHQW) improves the results of COVID-19 treatment. Three very recent studies analyzed with network pharmacology some working mechanisms LHQW. However, we used more techniques and also included Angiotensin converting enzyme 2 (ACE2) (a SARS-CoV receptor, possibly viral entry point in alveolar lung cells) immune system, as cytokine storm is essential late phase. Extensive detailed Network Pharmacology analysis LHQW-...
Calcium oxalate (CaOx) crystal can trigger kidney injury, which contributes to the pathogenesis of nephrocalcinosis. The phenotypes infiltrating macrophage may impact CaOx-mediated inflammatory injury as well deposition. How aryl hydrocarbon receptor (AhR) regulates inflammation and polarization is understood; however, how it modulates CaOx nephrocalcinosis remains unclear. Methods: Mice were intraperitoneally injected with glyoxylate establish model or without treatment AhR activator...
Abstract Background The HECT E3 ubiquitin ligase Nedd4 has been shown to positively regulate T cell responses, but its role in helper (Th) differentiation and autoimmunity is unknown. Th17 cells are believed play a pivotal the development pathogenesis of autoimmune diseases. Nevertheless, regulation RORγt activation during by TCR signaling yet be elucidated. These uncharted aspects inspire us explore potential Th17-mediated autoimmunity. Methods We evaluated impact deficiency on mouse using...
Recent studies have uncovered that accumulation of glutamate after ischaemic stroke is closely associated with the down-regulation transporter-1 (GLT-1) expression, suggesting GLT-1 expression critically controls and abnormal transport-elicited neuronal cell excitotoxicity in patients stroke. However, it remains unknown how regulated under conditions. In present study, we screened nine brain-specific or brain-enriched miRNAs a focal cerebral ischaemia/reperfusion (I/R) injury rat model,...
Kidney Renal Clear Cell Carcinoma (KIRC) accounts for 75% of all renal cancers. Previous study had conflict evidences regarding NR1B2 role in cancer, and its expression biological KIRC remained unclear. Our aims were to characterize the KIRC.NR1B2 TCGA database analyzed. Clinical samples examined by RT-PCR, western blot tissue microarray (TMA). The relationship between clinical characteristics evaluated. cell line stably overexpressed or with an knocked down using lentivirus system. cells...
To explore the autoimmune response and outcome in central nervous system (CNS) at onset of viral infection correlation between autoantibodies viruses. Methods A retrospective observational study was conducted 121 patients (2016–2021) with a CNS confirmed via cerebrospinal fluid (CSF) next-generation sequencing (cohort A). Their clinical information analysed CSF samples were screened for against monkey cerebellum by tissue-based assay. In situ hybridisation used to detect Epstein-Barr virus...
Abstract Accumulating evidence shows HOOK1 disordered in human malignancies. However, the clinicopathological and biological significance of renal cell carcinoma (RCC) remains rarely studied. In this study, authors demonstrate that is downregulated RCC samples with predicted poorer clinical prognosis. Mechanistically, inhibits tumor growth metastasis via canonical TGF‐ β /ALK5/p‐Smad3 non‐canonical /MEK/ERK/c‐Myc pathway. At same time, angiogenesis sunitinib resistance by promoting...
Atherosclerosis, a multifactorial chronic disease, is the main cause of death and impairment in world. Endothelial cells (ECs) apoptosis plays crucial role onset development atherosclerosis, whereas underlying molecular mechanisms are unclear. MicroRNA-142-3p (miR-142-3p) well-defined tumor suppressor several types cancer, while miR-142-3p ECs atherosclerosis has yet to be elucidated. Therefore, present study aimed investigate during mechanism.Human aortic endothelial (HAECs) were treated...
The authors sought to examine whether brain activity is associated with treatment response cognitive-behavioral therapy (CBT) in adolescents and adults obsessive-compulsive disorder (OCD), any associations are specific relative an active control psychotherapy (stress management therapy; SMT).Eighty-seven patients OCD (age range 12-45 years; 57 female, 39 medicated) were randomly assigned receive 12 weeks of CBT or SMT. Prior treatment, functional MRI scans conducted performing incentive...
Lung cancer is the leading cause of death worldwide and small cell lung (SCLC) accounts for a significant proportion all cases. Even so, underlying mechanism governing SCLC development remains poorly understood related stands high despite decades intensive investigation. We noted that both miR-138 H2AX have been implicated in various malignancies. Also, there recent report showing role mediating DNA damage response by targeting H2AX. In light these data, we sought to characterize growth...