A5029279187- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- Cancer Genomics and Diagnostics
- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Cervical Cancer and HPV Research
- AI in cancer detection
- Molecular Biology Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- HER2/EGFR in Cancer Research
- Cancer Cells and Metastasis
- Genetic factors in colorectal cancer
- Cancer-related Molecular Pathways
- Estrogen and related hormone effects
- Cancer-related molecular mechanisms research
- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
- Medical Imaging Techniques and Applications
- Lung Cancer Treatments and Mutations
- Morphological variations and asymmetry
- Endometriosis Research and Treatment
- Genomic variations and chromosomal abnormalities
- Physics of Superconductivity and Magnetism
- Gastric Cancer Management and Outcomes
- Monoclonal and Polyclonal Antibodies Research
Stavanger University Hospital
2012-2025
University of Amsterdam
2002-2014
University of Bergen
2005-2014
Fudan University Shanghai Cancer Center
2012-2013
Vrije Universiteit Amsterdam
1996-2010
Univé (Netherlands)
2009
Amsterdam UMC Location University of Amsterdam
2008
Amsterdam UMC Location Vrije Universiteit Amsterdam
2002-2007
University Medical Center
2002-2007
University Hospital and Clinics
2007
AIMS: Chromosomal gains and losses were surveyed by comparative genomic hybridisation (CGH) in a series of colorectal adenomas carcinomas, search high risk changes involved carcinogenesis. METHODS: Nine 14 carcinomas analysed CGH, DNA ploidy was assessed with both flow image cytometry. RESULTS: In the nine analysed, an average 6.6 (range 1 to 11) chromosomal aberrations identified. 11.9 5 17) events found per tumour. number balance (3.6 v 3.0) while occurred more often than (8.2 3.7)....
Gudlaugsson E, Skaland I, Janssen E A M, Smaaland R, Shao Z, Malpica A, Voorhorst F & Baak J P (2012) Histopathology Comparison of the effect different techniques for measurement Ki67 proliferation on reproducibility and prognosis prediction accuracy in breast cancer Aims: The factor is prognostic included international therapy guidelines, but procedures differ between laboratories. We compared value sampling methods. Methods results: In 237 T 1,2 N 0 M cancers without adjuvant systemic...
The traditional Chinese Medicine (TCM) herbal formula Lian Hua Qing Wen (LHQW) improves the results of COVID-19 treatment. Three very recent studies analyzed with network pharmacology some working mechanisms LHQW. However, we used more techniques and also included Angiotensin converting enzyme 2 (ACE2) (a SARS-CoV receptor, possibly viral entry point in alveolar lung cells) immune system, as cytokine storm is essential late phase. Extensive detailed Network Pharmacology analysis LHQW-...
Management of endometrial precancers is compromised by longstanding debate over the natural history hyperplasias and inconsistencies in their diagnosis. The recent demonstration that some hyperplasias, like cancers, are phenotypically monoclonal useful recognizing biological precancers. A clonal analysis has been undertaken a series 93 tissues morphology evaluated subjective diagnostic classification computerized morphometric analysis. pathologist's diagnosis atypical hyperplasia was highly...
We assessed the reproducibility and prognostic variability of grade lamina propria invasion in stages Ta, T1 urothelial carcinoma bladder.A total 130 consecutive carcinomas routinely diagnosed by 15 pathologists (original diagnosis) were reviewed 3 independent experienced using 1999 WHO criteria (diagnoses 1 to reviewer consensus diagnosis). Interreviewer disagreement cases blindly again. Each remaining case was discussed a multihead microscope session attempt solve disagreements. In...
Although invasive adenocarcinoma of the cervix constitutes 5--15% all cervical cancers, in situ counterpart is underrepresented published series percursor lesions cancer. Moreover, no cases are known to have been which preceded Partly, this can be explained by fact that an underdiagnosed lesion. In a 52 uterine cervix, 18 "negative" endocervical biopsies, taken 3--7 years prior clinical presentation cancer, were available for study. five these cases, areas found. The quantitative parameters...
Purpose To validate the independent strong prognostic value of mitotic activity index (MAI) in lymph node (LN) –negative invasive breast cancer patients younger than 55 years a nationwide multicenter prospective study. Patients and Methods Analysis routinely assessed MAI other prognosticators 516 (median follow-up, 118 months; range, 8 to 185 months), without systemic adjuvant therapy or previous malignancies. Results Distant metastases occurred 127 (24.6%); 90 (17.4%) died as result...
The proportion of exfoliated buccal mucosal cells with micronuclei gives the opportunity to assess sensitivity gamma-radiation and genotoxic compounds in addition monitor effectiveness cancer intervention strategies. So far, results on counting various publications are difficult compare because differences methods used, especially regard microscopical magnification used number counted. aims this study were (i) define a protocol for micronuclei; (ii) feasibility manually (iii) assessment...
Abstract Previous studies have shown that 80–90 per cent of cases atypical hyperplasia the endometrium do not progress to cancer. Criteria predict outcome in an individual patient with are lacking, and hysterectomy is usual (over)treatment order avoid a 10–20 chance confrontation cancer later on course disease. A recent study has using nuclear morphometric classification rule, 15 patients without progression can be accurately separated from progression. However, as it unlikely morphometrical...
Although 60% of Stage I renal carcinoma patients die from tumor within 5 years postoperatively, a considerable percentage survive that period. Nuclear grading can help to predict the outcome, but many are Grade 2, and prognosis this subclass is uncertain. Therefore, nuclear morphometry was carried out in 41 with cell carcinoma. Of these, 24 died 17 have survived Using mean area 32 μm2 as decision threshold, none short-term survivors below threshold three long-term exceed value (18%...
Introduction Although lymph node negative (LN-) breast cancer patients have a good 10-years survival (∼85%), most of them still receive adjuvant therapy, while only some benefit from this. More accurate prognostication LN- patient may reduce over- and under-treatment. Until now proliferation is the strongest prognostic factor for patients. The small molecule microRNA (miRNA) has opened new window markers, therapeutic targets and/or components. Previously it been shown that miR-18a/b, miR-25,...