A5015030195- Breast Cancer Treatment Studies
- Cervical Cancer and HPV Research
- Endometrial and Cervical Cancer Treatments
- Breast Lesions and Carcinomas
- HER2/EGFR in Cancer Research
- Cancer Genomics and Diagnostics
- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
- Ovarian cancer diagnosis and treatment
- Estrogen and related hormone effects
- Cancer-related Molecular Pathways
- Genetic factors in colorectal cancer
- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- Molecular Biology Techniques and Applications
- Colorectal and Anal Carcinomas
- Uterine Myomas and Treatments
- Colorectal Cancer Treatments and Studies
- Colorectal Cancer Screening and Detection
- Genital Health and Disease
- Neuroendocrine Tumor Research Advances
- Lung Cancer Research Studies
- Cancer Cells and Metastasis
- Metabolism, Diabetes, and Cancer
- AI in cancer detection
Stavanger University Hospital
2015-2025
University of Bergen
2007-2014
Duke Medical Center
2012
Obstetrics and Gynecology Hospital of Fudan University
2012
The University of Texas MD Anderson Cancer Center
2012
Duke University Hospital
2012
Skåne University Hospital
2012
Lund University
2012
Vrije Universiteit Amsterdam
2011
International Research Institute of Stavanger
2011
•We observed an objective response to olaparib in 18 out of 32 (56%) unselected, primary triple negative breast cancers.•Homologous recombination deficiency (HRD) was determined by targeted DNA sequencing and BRCA1 methylation.•HRD predictive present 16 responders.•HRD also beyond germline BRCA1/2 gPALB2 mutations; 12 14 responders.•Olaparib associated with minor side-effects did not influence subsequent tolerance chemotherapy. BackgroundThe antitumor efficacy PARP inhibitors (PARPi) for...
Gudlaugsson E, Skaland I, Janssen E A M, Smaaland R, Shao Z, Malpica A, Voorhorst F & Baak J P (2012) Histopathology Comparison of the effect different techniques for measurement Ki67 proliferation on reproducibility and prognosis prediction accuracy in breast cancer Aims: The factor is prognostic included international therapy guidelines, but procedures differ between laboratories. We compared value sampling methods. Methods results: In 237 T 1,2 N 0 M cancers without adjuvant systemic...
Abstract Background The lack of uniform criteria for coding gastroenteropancreatic neuroendocrine neoplasia (GEP-NEN) has hampered previous epidemiological studies. epidemiology GEP-NEN was investigated in this study using currently available criteria. Methods All patients diagnosed with between January 2003 and December 2013 a well defined Norwegian population approximately 350 000 people were included. Age- sex-adjusted incidence rates calculated. current 2010 World Health Organization...
Introduction Although lymph node negative (LN-) breast cancer patients have a good 10-years survival (∼85%), most of them still receive adjuvant therapy, while only some benefit from this. More accurate prognostication LN- patient may reduce over- and under-treatment. Until now proliferation is the strongest prognostic factor for patients. The small molecule microRNA (miRNA) has opened new window markers, therapeutic targets and/or components. Previously it been shown that miR-18a/b, miR-25,...
Abstract Purpose Quantification of Ki67 in breast cancer is a well-established prognostic and predictive marker, but inter-laboratory variability has hampered its clinical usefulness. This study compares the value reproducibility scoring using four automated, digital image analysis (DIA) methods two manual methods. Methods The cohort consisted 367 patients diagnosed between 1990 2004, with hormone receptor positive, HER2 negative, lymph node negative cancer. Manual was performed predefined...
European treatment guidelines of TaT1 urinary bladder urothelial carcinomas depend highly on stage and WHO1973-grade but grading reproducibility is wanting. The newer WHO2004 system still debated both systems are currently used.To compare prognostic value (of progression) the WHO1973 WHO2004.One hundred ninety-three primary were reviewed. Follow-up data retrieved from patient records. Kappa statistics Harrell's C-index used.Median follow-up was 75 months (range 1-127). 17 patients (9%)...
Background and aims 15–30% of cases cervical intraepithelial neoplasia grades 2–3 (CIN2–3) detected in punch biopsies regress spontaneously (ie, show CIN1 or less the follow-up cone). Epithelial retinoblastoma protein (pRb), tumour suppressor (p53), HPV genotype immunoreactive cells have been reported to be helpful predicting regression but their interaction prediction is unknown. Material methods 55 CIN2–3 with subsequent cones were studied retrospectively assess how epithelial biomarkers,...
PURPOSE Homologous recombination deficiency (HRD) is highly prevalent in triple-negative breast cancer (TNBC) and associated with response to PARP inhibition (PARPi). Here, we studied the prevalence of HRD non-TNBC assess potential for PARPi a wider group patients cancer. METHODS status was established using targeted gene panel sequencing (360 genes) BRCA1 methylation analysis pretreatment biopsies from 201 primary phase II PETREMAC trial (ClinicalTrials.gov identifier: NCT02624973 )....
Aims Triple-negative breast cancer (TNBC) is prognostically and therapeutically heterogeneous. The mitotic activity index (MAI) fibrotic focus (FF) have been established as predictors in non-TNBC but not TNBC. Late distant metastases occur TNBC, previous studies had short follow-up. High stromal tumour-infiltrating lymphocytes (sTILs) are favourable, prognostic sTILs-thresholds well assessed. We evaluated prognostic/predictive characteristics an observational population-based cohort of 231...
Background: Biobanking of prostate cancer tissue is crucial for advancing biomarker-guided precision medicine. However, there no standardized optimal protocol biobanking prostatectomy specimens. This study aims to compare the representativeness and sustainability two protocols-"Punch" "Slice"-currently used in Norway. Methods: Fresh frozen from 40 radical specimens was biobanked using both Punch Slice protocols. Following macroscopic evaluation, a 2 mm thick transverse slice (Slice protocol)...
ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Gudlaugsson E, Klos J, Skaland I, et al. Prognostic comparison of the proliferation markers mitotic activity index, phosphohistone H3, Ki67, steroid receptors, HER2, high molecular weight cytokeratins and classical prognostic factors in T1-2N0M0 breast cancer. Polish Journal Pathology. 2013;64(1):1-8. doi:10.5114/pjp.2013.34596. APA Gudlaugsson, E., Klos, J., Skaland, I., Janssen, Smaaland, R., & Feng, W....
Proliferation, either as the main common denominator in genetic profiles, or form of single factors such Ki67, is recommended for clinical use especially estrogen receptor-positive (ER) patients. However, due to high costs profiles and lack reproducibility studies on other proliferation are warranted. The aim present study was evaluate prognostic value mitotic activity index (MAI), phosphohistone H3 (PPH3), cyclin B1, A alone combinations. In 222 consecutive premenopausal node-negative...
A subset of triple-negative breast cancer (TNBC) expresses the androgen receptor (AR), but thresholds for AR positivity and its clinical significance vary. We hypothesize that objective assessment outperforms subjective methods, high negatively impacts prognosis. In a population-based TNBC cohort (n = 198) with long follow-up (4–383 months), expression was evaluated via scoring (AR-Manual) automated digital image analysis (AR-DIA). 10% cut-off value AR-DIA strongest negative prognostic...
Cervical intraepithelial neoplasia (CIN) is caused by human papillomavirus (HPV); however, factors such as HPV genotype and individual immune response may also contribute to its development. The loop electrosurgical excision procedure (LEEP) a treatment for high-grade cervical (CIN), approximately 30% of these cases progress cancer. However, 20–40% will regress spontaneously. HPV16 infection constitutes the highest risk progression cancer lower probability regression. Knowledge regarding...