A5064094413- Cervical Cancer and HPV Research
- Cancer-related Molecular Pathways
- Head and Neck Cancer Studies
- Cell death mechanisms and regulation
- Cancer Genomics and Diagnostics
- Cancer Cells and Metastasis
- Genital Health and Disease
- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Liver physiology and pathology
- Pancreatic function and diabetes
- Cancer Immunotherapy and Biomarkers
- Forensic Toxicology and Drug Analysis
- Protein Kinase Regulation and GTPase Signaling
- RNA modifications and cancer
- Viral-associated cancers and disorders
- Oral Health Pathology and Treatment
- Molecular Biology Techniques and Applications
- Reproductive tract infections research
- Proteoglycans and glycosaminoglycans research
- Drug Transport and Resistance Mechanisms
- Fibroblast Growth Factor Research
- Head and Neck Surgical Oncology
- Esophageal Cancer Research and Treatment
- Endometrial and Cervical Cancer Treatments
University of Bergen
2015-2025
Haukeland University Hospital
2016-2025
Prince of Wales Hospital
2013
University of California, San Francisco
2013
Okayama University
2013
Neurological Surgery
2013
Emory University
2013
Cleveland Clinic
2013
Translational Genomics Research Institute
2013
In-Q-Tel
2005
•We observed an objective response to olaparib in 18 out of 32 (56%) unselected, primary triple negative breast cancers.•Homologous recombination deficiency (HRD) was determined by targeted DNA sequencing and BRCA1 methylation.•HRD predictive present 16 responders.•HRD also beyond germline BRCA1/2 gPALB2 mutations; 12 14 responders.•Olaparib associated with minor side-effects did not influence subsequent tolerance chemotherapy. BackgroundThe antitumor efficacy PARP inhibitors (PARPi) for...
Novel (Rp)-cAMPS analogs differed widely in ability to antagonize cAMP activation of pure cAMP-dependent protein kinase I and II actions on gene expression, shape change, apoptosis, DNA replication, phosphorylation intact cells. These differences were related different abilities the stabilize holoenzyme form relative dissociated type II.(Rp)-8-Br-cAMPS (Rp)-8-Cl-cAMPS most potent antagonists for isolated cells expressing mostly kinase, like IPC-81 leukemia cells, fibroblasts transfected with...
Angiogenesis is regarded as a hallmark of cancer progression and it has been postulated that solid tumor growth depends on angiogenesis. At present, however, clear cell invasion can occur without angiogenesis, phenomenon particularly evident by the infiltrative malignant brain tumors, such glioblastomas (GBMs). In these amplification or overexpression wild-type (wt) truncated constitutively activated epidermal factor receptor (EGFR) are important events in GBM development, where complex...
IntroductionAcquired cancer therapy resistance evolves under selection pressure of immune surveillance and favors mechanisms that promote drug through cell survival evasion. AXL receptor tyrosine kinase is a mediator phenotypic plasticity suppression tumor immunity, expression associated with diminished long-term in wide range malignancies, including NSCLC.MethodsWe aimed to investigate the underlying AXL-mediated acquired first- third-generation small molecule EGFR inhibitors (EGFRi)...
The potent natural toxins microcystin, nodularin, and okadaic acid act rapidly to induce apoptotic cell death. Here we show that the apoptosis correlates with protein phosphorylation events can be blocked by kinase inhibitors directed against multifunctional Ca<sup>2+</sup>/calmodulin-dependent II (CaMKII). used comprised a battery of cell-permeable antagonists CaMKII-directed peptide introduced microinjection or enforced expression. Furthermore, could induced expression active forms CaMKII...
Despite successful implementation of drugs targeting the human epidermal growth factor receptor 2 (HER2) in breast and gastric cancers, potential HER2 as a therapeutic target other cancers has been less studied, including endometrial cancer. We investigated expression levels (ERBB2) large cohort cancer lesions, also complex atypical hyperplasia metastatic lesions. 67 precursor 790 primary 383 lesions were for relation to clinicopathologic features outcome. Protein assessed by...
To evaluate clinico-pathological and molecular prognostic factors in a well-defined series of posterior uveal melanoma (UM) with focus on chromosomal aberrations mutations the GNAQ, GNA11 BRCA1-associated protein 1 (BAP1) genes.Formalin-fixed paraffin-embedded (FFPE) tissue samples were obtained from 50 consecutive eyes enucleated for UM between 1993 2005. The material was tested loss chromosome 3 gain 8q gene signatures by selective markers using multiplex ligation-dependent probe...
Abstract Determination of the transient increase in plasma homocysteine following administration excess methionine is an established procedure for diagnosis defects metabolism patients. This so‐called loading test has been used 25 years, but knowledge response various cell types to limited. In present paper we investigated export from cultured presence increasing concentrations (15–1,000 μM) methionine. For comparison export, rates per million cells were plotted versus density proliferating...
Abstract The master two‐dimensional gel database of human keratinocytes currently lists 3038 cellular proteins (2127 isoelectric focusing, IEF; and 911 nonequilibrium pH gradient electrophoresis, NEPHGE) many which correspond to post‐translational modifications. 763 have been identified (protein, name, organelle components, etc. ) they are listed both in alphabetical order with increasing SSP number, together their M r , p I localization credit the investigator(s) that aided identification....
Cyclic AMP-dependent protein kinase subunit expression was studied during the first 35 h of primary culture hepatocytes isolated from rats fed a restricted diet. In absence elevated cAMP ratio between regulatory (RI + RII) and catalytic (C) subunits constant. There an increase RI decrease RII, RI/RII rising 1 to 2.4 culturing studied. This disproportionate Rl reflected in RlamRNA relative RllamRNA. The liver previously noted after amino acid feeding starved thus reproduced when such animals...
High-grade gastroenteropancreatic neuroendocrine neoplasms (HG GEP-NEN) typically disseminate early. Treatment of metastatic disease has limited benefit and prognosis is generally discouraging. Data on the clinical impact mutations in HG GEP-NEN are scarce. There an unmet need for reliable biomarkers to predict treatment outcome GEP-NEN. Patients with diagnosed at three centres were selected KRAS-, BRAF mutation microsatellite instability (MSI) analyses. Results linked overall survival....
Abstract Background An organic extract of the recreational herb khat ( Catha edulis Forsk.) triggers cell death in various leukemia lines vitro . The chemotherapeutics camptothecin, a plant alkaloid topoisomerase I inhibitor, was tested side-by-side with panel acute myeloid to elucidate mechanisms toxicity. Results Khat had profound effect on MOLM-13 cells inducing mitochondrial damage, chromatin margination and morphological features autophagy. effects ultrastructure correlated strongly...
Erdheim-Chester disease is a rare histiocytosis characterized by multi-systemic organ involvement. Immune-modulating agents such as interferon-alpha have limited success and the disorder progressive causes high morbidity mortality. Treatment with BRAF-inhibitor vemurafenib has recently produced substantial improvement in three patients expressing p. V600E BRAF mutation. The commonly affects central nervous system it not yet known whether can reverse intra-axial infiltration resulting...
Abstract Background: Cervical cancer screening programs are facing a programmatic shift where protocol based on human papillomavirus testing (HPV-Screening protocol) is replacing the liquid-based cytology (LBC-Screening protocol). For safe technology transfer within nationwide programme in Norway, HPV-Screening was implemented randomized to compare real-world effectiveness of and LBC-Screening at first round. Methods: Among 302,295 women ages 34 69 years scheduled attend from February 2015...
PURPOSE Homologous recombination deficiency (HRD) is highly prevalent in triple-negative breast cancer (TNBC) and associated with response to PARP inhibition (PARPi). Here, we studied the prevalence of HRD non-TNBC assess potential for PARPi a wider group patients cancer. METHODS status was established using targeted gene panel sequencing (360 genes) BRCA1 methylation analysis pretreatment biopsies from 201 primary phase II PETREMAC trial (ClinicalTrials.gov identifier: NCT02624973 )....
The implementation of high-risk human papillomavirus testing (hrHPV testing) as a screening method in substitute for cytology has evoked the need more sensitive and less objective tests triage HPV-positive women. In cohort 1763 women, potential immunocytochemical p16 Ki-67 dual staining compared to cytology, alone or combination with HPV partial genotyping, was tested women attending cervical cancer program. Performance measured using sensitivity, specificity, positive negative predictive...
ABSTRACT Lymphoplasmacytic lymphomas (LPL) are usually associated with serum monoclonal immunoglobulin M (IgM). Nevertheless, in some cases, these cells may secrete IgA or IgG proteins remain non‐secretory. We report a case from patient LPL‐secreting who developed anaemia and splenomegaly during the disease course that necessitated treatment bortezomib, dexamethasone, rituximab. The illustrates need for clinicians pathologists to consider LPLs as differential diagnosis also without IgM....