We studied the time-dependent relationships between microvascular obstruction (MO), infarct size, and left ventricular (LV) remodelling after acute myocardial infarction (MI). Forty-two consecutive patients with first-time ST-elevation MI, single-vessel disease, successfully treated primary percutaneous coronary intervention (PCI) were included. Microvascular obstruction, LV assessed by cardiac magnetic resonance. Cardiac resonance was performed at: 2 days, 1 week, months, year following...

<h3>Objectives:</h3> To compare the prevalence and pattern of neuropsychiatric (NP) syndromes observed in systemic lupus erythematosus (SLE) to patients with Primary Sjögren syndrome (PSS) using American College Rheumatology (ACR) criteria for 19 NP seen SLE. <h3>Methods:</h3> A population-based study was conducted including 68 SLE (mean (SD) age 43.8 (13.6) years) 72 PSS (age 57.8 (13.0) years). Specialists internal medicine, neurology neuropsychology performed standardised examinations....

Abstract Dementia is a common complication of Parkinson's disease (PD), but the cause incompletely understood. In previous studies, dementia has been associated with an increase in hyperintense lesions cerebral white matter. The aim this study was to explore whether matter hyperintensities (WMH) on magnetic resonance imaging (MRI) are PD. For study, 35 patients PD, 16 (PDD) and 19 without (PDND), 20 control subjects were recruited. MRI scans controls rated for WMH, blind diagnosis, using...

Cognitive dysfunction is common in both systemic lupus erythematosus (SLE) and primary Sjögren's syndrome (SS). Antibodies against the NR2 subtype of N-methyl-D-aspartate receptor (anti-NR2 antibodies) cause hippocampal atrophy cognitive impairment mice have been associated with memory patients SLE SS. In addition, a reduced volume gray matter has demonstrated This study was undertaken to investigate whether there connection between presence anti-NR2 antibodies human diseases.Fifty 50 SS...

Circulating cardiac troponin levels increase following prolonged intense physical exercise. The aim of this study was to identify participants with highly elevated troponins after prolonged, high intensity exercise, and evaluate these for subclinical coronary artery disease. Ninety-seven recreational cyclists without known cardiovascular disease or diabetes, participating in a 91 km mountain bike race were included, 74 (76%) males, age: 43 ± 10 years, duration: 4.2 (3.6–4.7) h. Blood...

To explore the relationship between white matter hyperintensities (WMH) and prevalence course of depressive symptoms in mild Alzheimer's disease (AD) Lewy body dementia.This is a prospective cohort study conducted secondary care outpatient clinics western Norway.The population consisted 77 elderly people with dementia diagnosed according to standardised criteria.Structured clinical interviews physical, neurological, psychiatric, neuropsychological examinations were performed routine blood...

Background Sudden cardiac death among middle-aged recreational athletes is predominantly due to myocardial ischaemia. This study examined whether measuring troponin I and T (cTnI cTnT) after strenuous exercise could identify occult obstructive coronary artery disease. Design Prospective observational study. Methods Subjects were recruited from 1002 asymptomatic cyclists completing a 91-km mountain bike race (North Sea Race Endurance Exercise Study). No subject had known cardiovascular...

Abstract Background To test the hypothesis that neurofilament light (NfL) in CSF is a biomarker of CNS involvement patients with systemic lupus erythematosus (SLE) and primary Sjögren’s syndrome (pSS), we measured NfL from 52 54 pSS explored associations clinical, structural, immunological biochemical abnormalities. Methods In CSF, NfL, anti-P antibodies, protein S100B TWEAK by ELISA anti-NR2 antibodies electrochemiluminescence. Anti-phospholipid routine tests were performed blood. IgG...

Fatigue is a disabling phenomenon in many patients who have systemic lupus erythematosus (SLE). The pathophysiological processes are unknown, and no known biological disease factors influence the phenomenon. Because depressive mood consistently associated with fatigue, drug treatment for SLE does not ameliorate psychological explanation could be an alternative. In search of somatic basis we looked alternative markers biologic activity fatigue. Cerebral white matter hyperintensities (WMHs)...

Introduction The objective of this study was to compare the prevalence primary headaches in systemic lupus erythematosus (SLE) versus healthy subjects, and determine whether SLE are associated with MRI- or cere-brospinal fluid (CSF) abnormalitites. Patients methods case-control included CSF investigations. Headache classified according International Classification Disorders. Depression fatigue were measured Beck Inventory (BDI) Fatigue Severity Scale (FSS) respectively. Results Twenty-four...

Our understanding of the etiology and pathogenesis neuropsychiatric involvement in primary Sjögren's syndrome (SS) is incomplete. In systemic lupus erythematosus, it has been reported that antibodies directed against N-methyl-D-aspartate receptor subtype NR2 (anti-NR2) interfere with memory learning function, as well mood. This not investigated SS; however, present study was undertaken to advance our this disease.Sixty-six patients SS 66 age- sex-matched healthy control subjects underwent...

Abstract A scar pregnancy is an ectopic implanted in a previous lower segment cesarean scar, and the incidence of this complication may be expected to rise along with increasing section rates. Arteriovenous malformation uterus congenital, associated early loss, trophoblastic disease, or surgical procedures. We describe case uterine arteriovenous as consequence pregnancy, complicated by recurrent, serious bleeding. The condition was diagnosed using three‐dimensional ultrasound color Doppler...

It is frequently thought that cerebral white matter hyperintensities (WMHs) on T-2 weighted MRI scans are increased in patients with autoimmune diseases. An frequency of WHMs has been described primary Sjögren's syndrome (PSS), but no controlled studies exist. The aim this study was therefore to compare WMHs PSS and healthy subjects applying the new European-American criteria for PSS.Cross-sectional 68 unselected carried out. were rated using Scheltens method.There differences total or any...

Background We investigated whether the prevalence of primary headaches was higher in patients with Sjøgren's syndrome ( PSS ) than healthy individuals. Methods This retrospective cohort study included 71 (patients) based on American European Consensus Classification criteria, and age‐ gender‐matched subjects (controls). Headaches were classified according to International Headache Disorders. measured depression Beck Depression Inventory, fatigue Fatigue Severity Scale. Results Fifty‐one 42...

Background and purpose Although brain involvement is common in primary S jögren's syndrome ( pSS ), results from cerebral imaging studies are inconsistent. This study aimed to perform both voxel‐wise global volume analyses a nearly population‐based cohort explore whether the patients displayed any focal or diffuse differences compared with healthy subjects. Methods Global grey matter GM ) white WM volumes were measured 60 p SS age‐ gender‐matched Regression models constructed potential...

Background and purpose Migraine is frequent in patients with systemic lupus erythematosus ( SLE ), but the pathogenesis pathophysiology are poorly understood. assumed to be a consequence of abnormal neuronal excitability. Based on hypothesis that threshold for migraine lower due cerebral disturbances, whether structural abnormalities brain or relevant biomarkers associated headaches was investigated. Methods Sixty‐seven age‐ gender‐matched healthy subjects participated. Volumes grey matter...

Recent cross-sectional studies have suggested a dose-dependent relationship between lifelong exposure to physical activity and the burden of calcified coronary artery disease (CAD). No longitudinal addressed this concern.Exercise volume is associated with progression calcium (CAC), defined as ≥10 units increase in CAC score.Sixty-one recreational athletes who were assessed by computed tomography angiography (CCTA) part NEEDED 2013/14 study re-assessed 4-5 years later, 2018.Subjects 45.9 ±...

White matter hyperintensities (WMH) in magnetic resonance imaging (MRI) scans of the brain, and orthostatic hypotension (OH) are both common older people. We tested hypothesis that OH is associated with WMH.Cross-sectional study.Secondary care outpatient clinics geriatric medicine old age psychiatry western Norway.160 patients mild dementia, diagnosed according to standardised criteria.OH was consensus definition, measuring blood pressure (BP) supine position within 3 minutes standing...

Mild courses of haemolytic disease the foetus or newborn (HDN) due to Rh (D) blood group antibodies are associated with and may therefore be ameliorated by maternal reacting human leucocyte antigens (HLA) child, an observation drawn from our own earlier data (Neppert J, Kissel K. Lancet 1992;339:1481). This study (i) corroborates this association; (ii) reveals shortcomings in published data; (iii) examines characteristics HDN cases when these have been rectified. Samples 51 women against...

Objective A prevailing hypothesis for neuropsychiatric involvement in systemic lupus erythematosus (SLE) and primary Sjögren’s syndrome is that brain reactive autoantibodies enter the through a disrupted blood–brain barrier. Our aim was to investigate whether TNF-like weak inducer of apoptosis (TWEAK) plays role cerebral human SLE syndrome, an impaired barrier prerequisite manifestations. Methods TWEAK measured cerebrospinal fluid serum compared with markers permeability (Q-albumin MRI...

Patients with psychiatric conditions are often referred for a brain scan during the course of their diagnostic workup.The aim our study is to determine frequency and type organic pathology, relationship age, gender diagnosis.We investigated magnetic resonance imaging computed tomography scans from consecutively patients over 10-year period (January 2002-December 2011). The reasons referral, estimated diagnosis, pathology discovered each patient were registered.A total 34% demonstrated which...

Ménétriere´s disease is a rare disorder of the body and fundus stomach, characterized by massive proliferation foveolar cells subsequent excess mucous secretion. This results in hypoproteinemia due to loss serum proteins across gastric mucosa. The cause unknown, irreversible premalignant character disorder, patients affected have been subdued gastrectomy as only curable treatment. Epidermial growth factor (EGF) has implicated pathogenesis, finding that makes receptive monoclonal antibody...