A5057518610- Neural dynamics and brain function
- Neuroscience and Music Perception
- Cancer Immunotherapy and Biomarkers
- Hearing Loss and Rehabilitation
- Neuroscience and Neuropharmacology Research
- Cancer, Hypoxia, and Metabolism
- Hearing, Cochlea, Tinnitus, Genetics
- Liver Disease Diagnosis and Treatment
- Systemic Lupus Erythematosus Research
- Hepatitis B Virus Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Ferroptosis and cancer prognosis
- Immune cells in cancer
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Tryptophan and brain disorders
- Neuroscience and Neural Engineering
- Hepatitis C virus research
- Stress Responses and Cortisol
- Atherosclerosis and Cardiovascular Diseases
- Cancer, Lipids, and Metabolism
- Neuroendocrine regulation and behavior
- Immunotherapy and Immune Responses
- Advanced Memory and Neural Computing
- Memory and Neural Mechanisms
Peking Union Medical College Hospital
2023-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2025
Harbin Medical University
2017-2025
First Affiliated Hospital of Henan University of Science and Technology
2025
China Medical University
2015-2024
Beijing YouAn Hospital
2013-2024
Capital Medical University
2013-2024
Xiangya Hospital Central South University
2020-2024
Sichuan Agricultural University
2024
Central South University
2020-2024
BACKGROUND. Identifying immune correlates of COVID-19 disease severity is an urgent need for clinical management, vaccine evaluation, and drug development. Here, we present a temporal analysis key mediators, cytokines, chemokines in blood hospitalized patients from serial sampling follow-up over 4 weeks.
Hypoxia plays an indispensable role in the development of hepatocellular carcinoma (HCC). However, there are few studies on application hypoxia molecules prognosis predicting HCC. We aim to identify hypoxia-related genes HCC and construct reliable models for diagnosis, recurrence patients as well exploring potential mechanism.Differentially expressed (DEGs) analysis was performed using The Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO) database four clusters were determined by a...
Abstract Background Neonatal hypoxic-ischemic encephalopathy (HIE) is one of the most common neurological problems occurring in perinatal period. However, there still not a promising approach to reduce long-term neurodevelopmental outcomes HIE. Recently, itaconate has been found exhibit anti-oxidative and anti-inflammatory effects. therapeutic efficacy HIE remains inconclusive. Therefore, this study attempts explore pathophysiological mechanisms oxidative stress inflammatory responses as...
In this study, we aimed to evaluate lymphocyte-activation gene-3 (LAG-3) expression and its prognostic value in neoadjuvant-treated triple-negative breast cancer (TNBC). LAG-3, programmed death-1 (PD-1), death ligand-1 (PD-L1), CD8+ tumor-infiltrating lymphocyte (TILs) levels were examined using immunohistochemistry 148 preand 114 post-neoadjuvant chemotherapy (NACT) specimens of human TNBC tissue. Correlations between clinicopathological features analyzed. Prognostic values for combined...
Background: Cancer patients often display dysfunctional anti-tumor T cell responses. Since noteworthy benefits of immune checkpoint pathway blockade, such as PD-1 inhibitors, have been achieved in multiple advanced cancers, the next critical question is which mono- or combinatorial blockade regimens may reinvigorate immunity those cancer while limiting immune-related adverse effects. Method: This study recruited, total, 172 primary (131 were blood-tumor matched patients) who treatment-naïve...
The pristane-induced lupus (PIL) model is a useful tool for studying environmental-related systemic erythematosus (SLE). However, neuropsychiatric manifestations in this have not been investigated detail. Because (NPSLE) an important complication of SLE, we the symptoms PIL mouse to evaluate its suitability NPSLE studies.PIL mice showed olfactory dysfunction accompanied by anxiety- and depression-like phenotype at month 2 or 4 after pristane injection. levels cytokines (IL-1β, IFN-α, IFN-β,...
Primary auditory cortex (A1) neurons are believed not to carry much information about tonal offsets because A1 in barbiturate-anesthetized animals usually described as having only onset responses. We investigated offset responses comparison with the caudal part of awake cats. Cells responding both onsets and were commonly found (59.2% recorded cells). Offset co-occurred phasic or components sustained These ON-OFF cells had diverse combinations offset- onset-frequency-receptive field (FRF):...
Background T follicular helper (TFH) cells are a special subpopulation of and can regulate humoral immune responses. This study examined whether the frequency CD4+CXCR5+ TFH could be associated with active immunity in chronic hepatitis B (CHB) patients. Methodology Findings The frequencies peripheral blood cells, inducible cell costimulator (ICOS), and/or programmed death 1 (PD-1) positive immune-active (IA), immune-tolerant (IT) CHB, healthy controls (HC) were characterized by flow...
In recent years, increasing evidence has confirmed that exosomal circular RNAs (circRNAs) serve a crucial role in the prognostic prediction and diagnosis of liver cancer (LC). The present study compared expression patterns circRNAs during transarterial chemoembolization (TACE). CircRNA sequencing analysis identified 390 differentially expressed between prior TACE following first operation groups 489 to second groups. Gene Ontology demonstrated they were associated with fatty acid metabolism,...
Hyperimmunoglobulin E syndrome (HIES) is a rare primary immunodeficiency disorder characterized by recurrent infections, severe eczema, and elevated serum immunoglobulin (IgE) levels. Genetic testing traditionally focuses on known genes such as STAT3 DOCK8, responsible for the majority of autosomal-dominant (AD-HIES) autosomal-recessive (AR-HIES) cases, respectively. However, significant subset patients with HIES-like symptoms remain genetically unexplained. Whole-exome sequencing (WES) has...
Dyslipidemia has been linked to acute promyelocytic leukemia (APL), with abnormal lipid metabolism observed during treatment. However, its role in APL pathogenesis remains unclear. This study investigates the relationship between serum levels and clinical features, risk stratification, bleeding tendency, prognosis of newly diagnosed patients, focusing on PTK2 gene regulating potential as a therapeutic target. We analyzed 90 patients 99 controls. Statistical analyses, including logistic...
Immune checkpoint inhibitor (ICI) has been widely used in lung cancer patients. While ICI treatment improves the overall survival of patients, it can also lead to a series immune-related adverse events (irAE). Severe irAE should be treated with glucocorticoids and biological agents. Opportunistic infections highly vigilant during We report patient locally advanced non-small cell who developed severe ICI-related colitis after chemotherapy combined immunotherapy. The hematogenous disseminated...
<title>Abstract</title> Background: Although ArfGAP with SH3 Domain, Ankyrin Repeat and PH Domain 1(ASAP1) is involved in the development of various malignancies, its clinical significance mechanism gastric cancer (GC) remains unclear.Methods: The effects ASAP1 on tumor progression, angiogenesis, epithelial-mesenchymal transition were evaluated vitro. growth angiogenesis also explored vivo. Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO) databases used to gather expression...
Interferon-induced transmembrane 3 (IFITM3) is known to restrict the entry of a range enveloped viruses. The single nucleotide polymorphism rs12252-C within IFITM3 has been shown be associated with severe influenza A virus infection. It suggested that results in expression truncated protein lacking first 21 amino acids. By performing high-throughput RNA sequencing on primary dendritic cells and peripheral blood mononuclear isolated from pandemic H1N1 human immunodeficiency virus-1 (HIV-1)...
As a hallmark of COVID-19 progression, lymphopenia alongside its subtle immune disturbance has been widely reported, but yet to be thoroughly elucidated. Aiming at exploring clinical biomarkers with accessibility in the current and acute omicron epidemic abrupted China post-control era, we design real-world prospective observation cohort Peking Union Medical College Hospital describe immunological, haematological profiles inducing lymphocyte subsets related SARS-CoV-2 infection. In this...
Repeated acoustic events are ubiquitous temporal features of natural sounds. To reveal the neural representation sound repetition rate, a number electrophysiological studies have been conducted on various mammals and it has proposed that both spike-time firing rate primary auditory cortex (A1) neurons encode rate. However, previous rarely examined how experimental animals perceive difference in caveat to these experiments is they compared physiological data obtained from with psychophysical...
The auditory steady-state response (ASSR) is a cortical oscillation induced by trains of 40 Hz acoustic stimuli. While the ASSR has been widely used in clinic measurement, underlying neural mechanism remains poorly understood. In this study, we investigated contribution different stages thalamocortical pathwaymedial geniculate body (MGB), thalamic reticular nucleus (TRN), and cortex (AC)to generation regulation C57BL/6 mice both sexes. We found that synchronizing to sound stimuli was most...
Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and healthcare burden worldwide. The progression COPD combination genetic predisposition environmental factors, primarily cigarette smoking, the underlying mechanisms are still unknown. Intestinal microecology impacts host immunity, metabolism, resistance to pathogenic infections, which may be involved in disease. Moreover, substantial interaction occurs between intestinal respiratory immune niches. After reviewing...
Sound duration is important for distinguishing auditory object. Previous studies on the neural representation of have usually lacked psychophysical data obtained from same species; hence, correspondence between and behavioral discrimination remains obscure. We addressed this issue in cats by using signal detection theory to investigate both activities primary cortex (A1) cat's performance. found that 320 ms can be well discriminated 10 some A1 neurons with specific response patterns:...
Abstract Background and Aim Abnormal lipid metabolism may contribute to the pathogenesis of non‐alcoholic steatohepatitis. ATP ‐binding cassette transporter A 1 ( ABCA 1) mediates transport cholesterol phospholipids from cells high density lipoprotein apolipoproteins. The lipidation apolipoprotein ‐ I (apo ) by is rate‐limiting step in reverse generation plasma lipoprotein. Here, we examined effect apo or overexpression on hepatic levels BEL ‐7402 cells. Methods Human was overexpressed...