The pristane-induced lupus (PIL) model is a useful tool for studying environmental-related systemic erythematosus (SLE). However, neuropsychiatric manifestations in this have not been investigated detail. Because (NPSLE) an important complication of SLE, we the symptoms PIL mouse to evaluate its suitability NPSLE studies.PIL mice showed olfactory dysfunction accompanied by anxiety- and depression-like phenotype at month 2 or 4 after pristane injection. levels cytokines (IL-1β, IFN-α, IFN-β,...

Glechomae Herba (GH) has been widely used in the treatment of urolithiasis, especially kidney stones, China and Southeast Asia. Pharmacological studies have suggested that antioxidant property GH contributes to its anticalculus effect. CaSR is one main locations mechanism action inhibitors stones similar GH. However, until now, antiurolithic chemical compounds their interaction with remain unknown. In our study, we revealed between active by using spectrum-effect relationship analysis,...

The auditory steady-state response (ASSR) is a cortical oscillation induced by trains of 40 Hz acoustic stimuli. While the ASSR has been widely used in clinic measurement, underlying neural mechanism remains poorly understood. In this study, we investigated contribution different stages thalamocortical pathwaymedial geniculate body (MGB), thalamic reticular nucleus (TRN), and cortex (AC)to generation regulation C57BL/6 mice both sexes. We found that synchronizing to sound stimuli was most...

Septic acute kidney injury (AKI) is the most common AKI syndrome in intensive care unit (ICU), and it accounts for approximately half of cases. Tofacitinib (TOFA) a pan-Janus kinase (JAK) inhibitor that exhibits potent anti-inflammatory activity rheumatoid arthritis. However, no study has examined functional role TOFA septic AKI. In present study, we investigated protective effects on underlying mechanisms. A lipopolysaccharide- (LPS-) induced model was established C57BL/6 mice via an...

Abstract Aims Intracerebral hemorrhage (ICH) is a devastating type of stroke without specific treatment. Activator protein 1 (AP‐1), as gene regulator, initiates cytokine expression in response to environmental stimuli. In this study, we investigated the relationship between AP‐1 and neuroinflammation‐associated brain injury triggered by ICH. Methods mice were developed autologous blood or collagenase infusion. We measured dynamics mouse tissues during neuroinflammation formation after The...

Abstract Background Neuropsychiatric manifestations are frequent in patients with systemic lupus erythematosus (SLE), yet the etiology and pathogenesis of brain damage SLE remains unclear. Because production autoantibodies, formation deposition immunocomplexes major serological characteristics SLE, elevated level serum immunoglobulin may contribute to tissue injury SLE. To testify this, this study, we examined whether G (IgG) affects cellular functions central nervous system potential...

Abstract Aims The hippocampus has been reported to be morphologically and neurochemically altered in schizophrenia (SZ). Hyperlocomotion is a characteristic SZ‐associated behavioral phenotype, which associated with dysregulated dopamine system function induced by hippocampal hyperactivity. However, the neural mechanism of underlying hyperlocomotion remains largely unclear. Methods Mouse pups were injected N ‐methyl‐ D ‐aspartate receptor antagonist (MK‐801) or vehicle twice daily on...

Systemic administration of noncompetitive N-methyl-D-aspartate receptor (NMDAR) antagonists such as MK-801 is widely used to model psychosis schizophrenia (SZ). Acute systemic in rodents caused an increase the auditory steady-state responses (ASSRs), oscillatory neural periodic stimulation, while most studies patients with SZ reported a decrease ASSRs. This inconsistency may be attributable comprehensive effects MK-801. Here, we examined how ASSR affected by selectively blocking NMDAR...

The mechanism underlying antimicrobial activity of conjugated bile acids against strains lactic acid bacilli is not well understood. purpose this study was to investigate two typical (glycochenodeoxycholic and taurochenodeoxycholic acid) for their mechanisms four different species at the physiological pH small intestine humans. bacterial cell membrane integrity, transmembrane potential, gradient were examined using fluorescence probes SYTO 9 plus propidium iodide,...

Auditory steady state response (ASSR) and inhibitory gating (IG) are electrophysiological examinations commonly used to evaluate the sensory cognitive functions of brain. In some clinic animal experiments, general anesthesia is necessary conduct recordings. However, effects on ASSR IG remain unclear. For this reason, we recorded local field potentials though electrodes implanted in different brain areas rats: auditory cortex (AC), hippocampus (HC), amygdala (AMY), prefrontal (PFC), compared...

Auditory steady-state responses (ASSRs) represent the electrophysiological activity of auditory nervous system in response to a periodic acoustic stimulus. Spectrogram analysis can reveal frequency and phase information entrained ASSRs. Clinically, ASSR is used detect abnormalities electroencephalographs obtained from schizophrenia patients, who show reduced power locking The neonatal ventral hippocampal lesion (NVHL) rat widely model investigate neurodevelopmental mechanisms schizophrenia....

Research has identified that epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) possess large benefits for adenocarcinoma (ADC), although little benefit squamous cell carcinoma (SCC). The aim of the present study was to investigate percentage patients with SCC EGFR mutations subset and TKIs in SCC. In study, detected an amplification refractory mutation system 1,359 clinical tissues. association clinicopathological parameters evaluated using Mann‑Whitney U test,...

Cigarette smoke is a major preventable risk factor of ischemic stroke. induces significant increase circulating leukocytes, however, it remains unclear to what extent and by mechanisms priming influences stroke severity. Here we report that exposure cigarette exacerbated brain injury in mice subjected transient middle cerebral artery occlusion (MCAO). The augmentation neurodeficits infarction was accompanied increased production pro-inflammatory factors infiltration neutrophils monocytes....

Neuropsychiatric systemic lupus erythematosus (NPSLE) is a serious phenotype of (SLE). The disturbance neuron-microglia crosstalk recently revealed in many neuropsychiatric diseases but was not well studied NPSLE. We found glucose regulatory protein 78 (GRP78), marker endoplasmic reticulum stress, significantly increased the cerebrospinal fluid (CSF) our NPSLE cohort. We, therefore, investigated whether GRP78 can act as mediator between and involved pathogenic process Serum CSF parameters...

To determine the influence of depth and size breast lesions, thickness adipose layer, on quality strain elastograms obtained from Chinese women.Ultrasound elastography was conducted 326 lesions in 272 women. The images evaluated according to criteria for satisfactory unsatisfactory elastograms. Univariate multivariate logistic regression analyses were relationship between measured factors image quality.Among 300 (92%) had images, 26 (8%) images. indicated that all data group higher than...

Central nervous system (CNS) involvement is commonly seen in the patients with lupus erythematosus (SLE). Mechanisms underlying CNS damage SLE remain largely unknown. Accumulating evidence suggest that activation of microglia plays an important role inflammatory responses neurological diseases. The aim this study to examine induced by circulating serum patients.We performed intracerebroventricular (ICV) injection serums collected from or healthy controls mice, and examined phenotypic changes...

Autoantibodies against ribosomal P proteins (anti-P antibodies) are strongly associated with the neuropsychiatric manifestations of systemic lupus erythematosus (NPSLE). The present study was designed to assess whether anti-P antibodies can induce abnormal brain electrical activities in mice and investigate potential cytopathological mechanism.Affinity-purified human anti-ribosomal were injected intravenously into after blood-brain barrier (BBB) disruption. auditory steady-state response...

A fundamental adaptive mechanism of auditory function is inhibitory gating (IG), which refers to the attenuation neural responses repeated sound stimuli. IG drastically impaired in individuals with emotional and cognitive impairments (i.e. posttraumatic stress disorder). The objective this study was test whether chronic impairs cortex (AC). We used standard two-tone stimulus paradigm examined parametric qualities AC rats by recording electrophysiological signals a single-unit local field...