A5100634936- Advanced biosensing and bioanalysis techniques
- Polysaccharides and Plant Cell Walls
- Seaweed-derived Bioactive Compounds
- Neuroinflammation and Neurodegeneration Mechanisms
- Biosensors and Analytical Detection
- Mitochondrial Function and Pathology
- Advanced Nanomaterials in Catalysis
- Gold and Silver Nanoparticles Synthesis and Applications
- Immune Cell Function and Interaction
- Immunodeficiency and Autoimmune Disorders
- Phytochemistry and Biological Activities
- Tea Polyphenols and Effects
- Gut microbiota and health
- Molecular Communication and Nanonetworks
- Inflammasome and immune disorders
- Acute Ischemic Stroke Management
- Liver Disease Diagnosis and Treatment
- Advanced Glycation End Products research
- Plant Gene Expression Analysis
- Pharmacological Effects of Natural Compounds
- Plant Diversity and Evolution
- Cytomegalovirus and herpesvirus research
- Vagus Nerve Stimulation Research
- Antioxidants, Aging, Portulaca oleracea
- Micro and Nano Robotics
Luye Pharma (China)
2025
University of Science and Technology of China
2025
Shandong University
2025
Shanghai Public Health Clinical Center
2025
Hunan University
2021-2024
State Key Laboratory of Food Science and Technology
2022-2024
Jiangnan University
2022-2024
Hunan Agricultural University
2021-2023
Shanghai Ninth People's Hospital
2023
Shanghai Jiao Tong University
2023
Abstract Aged microglia display augmented inflammatory activity after neural injury. Although aging is a risk factor for poor outcome brain insults, the precise impact of aging-related alterations in on injury remains poorly understood. Microglia can be eliminated via pharmacological inhibition colony–stimulating 1 receptor (CSF1R). Upon withdrawal CSF1R inhibitors, rapidly repopulate entire brain, leading to replacement microglial compartment. In this study, we investigated aged using mouse...
The tea-oil camellia (Camellia oleifera) is the most important oil plant in southern China, and has a strong resistance to drought barren soil. Understanding molecular mechanisms of tolerance would greatly promote its cultivation breeding.In total, we obtained 76,585 unigenes with an average length 810 bp N50 1,092 bp. We mapped all NCBI 'nr' (non-redundant), SwissProt, KEGG, clusters orthologous groups (COG) databases, where 52,531 (68.6%) were functionally annotated. According annotation,...
We evaluated the effects of yellow tea extract on relieving constipation induced by loperamide and changes gut microbiota based 16S rRNA gene sequencing.
Abstract EDA is a tumor necrosis factor (TNF) family member, which functions together with its cognate receptor EDAR during ectodermal organ development. Mutations of have long been known to cause X‐linked hypohidrotic dysplasia in humans characterized by primary defects teeth, hair and sweat glands. However, the structural information interaction lacking pathogenic mechanism variants poorly understood. Here, we report crystal structure C-terminal TNF homology domain bound N-terminal...
Environment‐recognizing DNA nanodevices have proven promising for cellular manipulation and disease treatment, whereas how to sequentially respond different microenvironments remains a challenge. To this end, here we elaborate logic‐gated intelligent nanorobot (Gi‐DR) the cascade response inter‐ intra‐cellular microenvironments, thereby achieving lysosome‐targeted cargo delivery subcellular interference tumor treatment with enhanced efficacy. Utilizing G‐quadruplexes high‐level K+ in cancer...
Environment‐recognizing DNA nanodevices have proven promising for cellular manipulation and disease treatment, whereas how to sequentially respond different microenvironments remains a challenge. To this end, here we elaborate logic‐gated intelligent nanorobot (Gi‐DR) the cascade response inter‐ intra‐cellular microenvironments, thereby achieving lysosome‐targeted cargo delivery subcellular interference tumor treatment with enhanced efficacy. Utilizing G‐quadruplexes high‐level K+ in cancer...
Objective: To study the therapeutic effect of Extract Wuwei Xiaodu Drink on spinal infection and provide scientific basis for clinical application. Methods: By establishing a rabbit model infection, this paper observed analyzed changes in body mass before after intervention comparison inflammation-related factors blood leukocyte counts among three groups. Results: There was significant difference rabbits experimental group, control group blank (P < 0.05); there no statistically...
The selenylation modification of Schisandra chinensis polysaccharide (SCP) was conducted by the HNO3–Na2SeO3 method respectively under nine conditions according to L9(34) orthogonal design. Nine selenizing SCPs, sSCP1–sSCP9, were obtained, and their antioxidant activities compared. In vitro test, free radical-scavenging rates sSCPs determined for DPPH., .OH ABTS+. sSCP1 presented most significant effect, could inhibit nonenzymatic protein glycation. vivo 14-day-old chickens injected with...
Aptamer-based lateral flow assay (Apt-LFA) has shown promising applications for small-molecule detection. However, the design of AuNP (gold nanoparticle)–cDNA (complementary DNA) nanoprobe is still a big challenge due to moderate affinity aptamer small molecules. Herein, we report versatile strategy AuNPs@polyA–cDNA (poly A, repeat sequence with 15 A bases) Apt-LFA. The contains polyA anchor blocker, complementary DNA segment on control line (cDNAc), partial (cDNAa), and auxiliary...
Obesity is regarded to be correlated with disorders of lipid metabolism, bile acid metabolism and dysbiosis the gut microbiota. Moringa-Fu brick tea (MFBT), a functional food, has significant anti-obesity effect. However, effectiveness mechanisms MFBT in preventing obesity require further investigation. Here, our results show that moringa-Fu extract (MFTE) displays effects by reducing high-fat diet-induced weight gain adipose tissue accumulation rats, attenuating visceral adiposity index,...
Cigarette smoke is a major preventable risk factor of ischemic stroke. induces significant increase circulating leukocytes, however, it remains unclear to what extent and by mechanisms priming influences stroke severity. Here we report that exposure cigarette exacerbated brain injury in mice subjected transient middle cerebral artery occlusion (MCAO). The augmentation neurodeficits infarction was accompanied increased production pro-inflammatory factors infiltration neutrophils monocytes....