A5011641575- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Molecular Communication and Nanonetworks
- Bacteriophages and microbial interactions
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Micro and Nano Robotics
- DNA and Nucleic Acid Chemistry
University of Science and Technology of China
2022-2025
Environment‐recognizing DNA nanodevices have proven promising for cellular manipulation and disease treatment, whereas how to sequentially respond different microenvironments remains a challenge. To this end, here we elaborate logic‐gated intelligent nanorobot (Gi‐DR) the cascade response inter‐ intra‐cellular microenvironments, thereby achieving lysosome‐targeted cargo delivery subcellular interference tumor treatment with enhanced efficacy. Utilizing G‐quadruplexes high‐level K+ in cancer...
Environment‐recognizing DNA nanodevices have proven promising for cellular manipulation and disease treatment, whereas how to sequentially respond different microenvironments remains a challenge. To this end, here we elaborate logic‐gated intelligent nanorobot (Gi‐DR) the cascade response inter‐ intra‐cellular microenvironments, thereby achieving lysosome‐targeted cargo delivery subcellular interference tumor treatment with enhanced efficacy. Utilizing G‐quadruplexes high‐level K+ in cancer...
Acute myocardial infarction (AMI)-related microRNAs (miRNAs) in circulating blood have been proved as promising biomarkers for AMI diagnosis. The detection of these miRNAs at ultralow levels usually requires nucleic acid amplification strategies to improve the sensitivity cost time. Given that first hour after an attack is golden time saving patients' lives, shortening ultrasensitive miRNA analysis great significance clinical Toward this goal, here we present a direct...
Exosomal microRNAs (miRNAs) play critical regulatory roles in many cellular processes, and so how to probe them has attracted increasing interest. Here we propose an aptamer-functionalized dimeric framework nucleic acid (FNA) nanoplatform for effective capture of exosomes directly probing internal miRNAs with electrochemiluminescence (ECL) detection, not requiring RNA extraction conventional counterparts. A CD63 protein-binding aptamer is tethered one the FNA structures, allowing be...
Abstract Developing synergistic targeted therapeutics to improve treatment efficacy while reducing side effects has proven promising for anticancer therapies, but how conveniently modulate multidrug cooperation remains a challenge. Here, novel strategy using G‐quadruplex‐programmed versatile nanorobot (G4VN) containing two subunits of DNAzyme (DzG4) and ligand‐drug conjugates (LDCs) is proposed precisely target tumors then execute both gene silencing chemotherapy. As the core module this...
Abstract Developing intelligently targeted drugs with low side effects is urgent for cancer treatment. Toward this goal, a tumor‐specific cascade‐activating smart prodrug system consisting of G‐quadruplex(G4)‐modulated tumor‐targeted DNA vehicle and well‐designed cellular stimuli‐responsive ligand‐drug conjugates (LDCs) proposed. An original “donor–acceptor” binary fluorescent ligand, ultrahigh affinity, brightness, photostability, engineered to tightly bind G4 structures significantly...