A5075857275- RNA Interference and Gene Delivery
- Electrospun Nanofibers in Biomedical Applications
- Proteoglycans and glycosaminoglycans research
- Virus-based gene therapy research
- Neuroinflammation and Neurodegeneration Mechanisms
- Polymer composites and self-healing
- biodegradable polymer synthesis and properties
- Neurogenesis and neuroplasticity mechanisms
- Nanoparticle-Based Drug Delivery
- Inhalation and Respiratory Drug Delivery
- Birth, Development, and Health
- MicroRNA in disease regulation
- Pregnancy and preeclampsia studies
- Polymer Surface Interaction Studies
- Glycosylation and Glycoproteins Research
- Reproductive System and Pregnancy
- Wood and Agarwood Research
- Dendrimers and Hyperbranched Polymers
- Liver physiology and pathology
- Adhesion, Friction, and Surface Interactions
- Blood properties and coagulation
- Hydrogels: synthesis, properties, applications
- Shoulder Injury and Treatment
- Elbow and Forearm Trauma Treatment
- Food Quality and Safety Studies
University of Akron
2013-2024
China Medical University
2022-2023
Second Hospital of Hebei Medical University
2020
Hebei Medical University
2020
Second Affiliated Hospital of Kunming Medical College
2019
Kunming Medical University
2019
Aero Engine Corporation of China (China)
2018
In-Q-Tel
2015
Weatherford College
2009
Sichuan University
2009
Abstract Hedgehog (Hh) signalling regulates hepatic fibrogenesis. MicroRNAs (miRNAs) mediate various cellular processes; however, their role in liver fibrosis is unclear. Here we investigate regulation of miRNAs chronically damaged fibrotic liver. MiRNA profiling shows that expression miR-378 family members (miR-378a-3p, miR-378b and miR-378d) declines carbon tetrachloride (CCl 4 )-treated compared with corn-oil-treated mice. Overexpression miR-378a-3p, directly targeting Gli3 activated...
Silver carbenes may represent novel, broad-spectrum antimicrobial agents that have low toxicity while providing varying chemistry for targeted applications. Here, the bactericidal activity of four silver carbene complexes (SCCs) with different formulations, including nanoparticles (NPs) and micelles, was tested against a panel clinical strains bacteria fungi are causative many skin soft tissue, respiratory, wound, blood, nosocomial infections. MIC, MBC multidose experiments were conducted...
Drug-loaded microneedle arrays for transdermal delivery of a chemotherapeutic drug were fabricated using multi-material microstereolithography (μSL). These consisted twenty-five poly(propylene fumarate) (PPF) microneedles, which precisely orientated on the same polymeric substrate. To control viscosity and improve mechanical properties PPF, diethyl fumarate (DEF) was mixed with polymer. Dacarbazine, is widely used skin cancer, uniformly blended into PPF/DEF solution prior to crosslinking....
A class of Ag(I) N-heterocyclic carbene silver complexes, 1-3, derived from 4,5-dichloro-1H-imidazole has been evaluated for their anticancer activity against the human cancer cell lines OVCAR-3 (ovarian), MB157 (breast), and Hela (cervical). Silver complexes 1-3 are active ovarian breast lines. preliminary in vivo study shows 1 to be mice. The results obtained these studies warrant further investigation compounds vivo.
The pristane-induced lupus (PIL) model is a useful tool for studying environmental-related systemic erythematosus (SLE). However, neuropsychiatric manifestations in this have not been investigated detail. Because (NPSLE) an important complication of SLE, we the symptoms PIL mouse to evaluate its suitability NPSLE studies.PIL mice showed olfactory dysfunction accompanied by anxiety- and depression-like phenotype at month 2 or 4 after pristane injection. levels cytokines (IL-1β, IFN-α, IFN-β,...
A high throughput screening technology enables identifying natural compounds, phytochemicals, that potently inhibit migration of metastatic breast cancer cells.
Many anticancer drugs have been established clinically, but their efficacy can be compromised by nonspecific toxicity and an inability to reach the desired cancerous intracellular spaces. In order address these issues, researchers explored use of folic acid as a targeted moiety increase specificity chemotherapeutic drugs. To expand upon such research, we conjugated functionalized poly(ethylene glycol) subsequently decorated surface l-tyrosine polyphosphate (LTP) nanoparticles. These...
Blood is a complex fluid that, among other things, has been established to behave as shear thinning, non-Newtonian when exposed low rates (SR). Many hemodynamic investigations use Newtonian represent blood the flow field of study relatively high SR (>200 s-1). Shear thinning fluids have shown exhibit differences in transition turbulence (TT) compared that fluids. Incorrect prediction point simulation could result erroneous force predictions. The goal present was compare velocity profiles...
Insult to the central nervous system (CNS) results in an early inflammatory response, which can be exploited as initial indicator of neurological dysfunction. Nanoparticle drug delivery systems provide a mechanism increase uptake drugs into specific cell types CNS such microglia, resident macrophage responsible for innate immune response. In this study, we developed two nanoparticle-based carriers potential theranostic microglial cells. Poly(lactic-co-glycolic) acid (PLGA)- and l-tyrosine...
Abstract Chitosan and its derivatives have emerged as promising gene-delivery vehicles because of their capability to form polyplexes with plasmid DNA enhance transport across cellular membranes through endocytosis. Evidently, chitosan significantly improve transfection efficiency; however, these are not capable sustained release and, thus, prolong gene transfer. In order achieve prolonged delivery DNA/chitosan polyplexes, we formulated microspheres by physically combining poly(ethylene...
Currently, viruses are utilized as vectors for gene therapy, since they transport across cellular membranes, escape endosomes, and effectively deliver genes to the nucleus. The disadvantage of using therapy is their immune response. Therefore, nanospheres have been formulated a nonviral vector by blending l-tyrosine-polyphosphate (LTP) with polyethylene glycol grafted chitosan (PEG-g-CHN) linear polyethylenimine (LPEI) conjugated plasmid DNA (pDNA). PEG-g-CHN stabilizes emulsion prevents...
Chemotherapy, a mainstay modality for cancer, is often hindered by systemic toxicity and side effects. With the emergence of nanomedicine, development drug therapy has shifted toward targeted therapy. Hyaluronan (HA) an ideal molecule as delivery system because many carcinomas overexpress HA receptors. We have conjugated resveratrol, natural polyphenol, 3-(5-methoxy, 2-methyl-1H-indol-3-yl)-1-(4-pyridinyl)-2-propen-1-one (MOMIPP), chalcone, to with goal enhancing bioavailability targeting...
Therapeutics for actively targeting over-expressed receptors are of great interest because the majority diseased tissues originate from normal cells and do not possess a unique receptor which they can be differentiated. One such is CD44, has been shown to highly overexpressed in many breast cancers other types cancer cells. While CD44 documented express low levels adult neurons, astrocytes, microglia, this may by neuroblastoma neuroglioma. If differential expression exists between cancerous...
Lung failure due to chronic bacterial infection is the leading cause of death for patients with cystic fibrosis (CF). It thought that nature these infections is, in part, increased tolerance and recalcitrant behaviour bacteria growing as biofilms. Inhalation silver carbene complex (SCC) antimicrobial, either encased polymeric biodegradable particles or aqueous form, has been proposed a treatment. Through coordinated experimental mathematical modelling effort, we examine this treatment lung...