A5049791266- Alzheimer's disease research and treatments
- Bioinformatics and Genomic Networks
- Genomics and Rare Diseases
- Cholinesterase and Neurodegenerative Diseases
- Dementia and Cognitive Impairment Research
- Natural Antidiabetic Agents Studies
- Natural product bioactivities and synthesis
- Advancements in Transdermal Drug Delivery
- Neurological diseases and metabolism
- Prion Diseases and Protein Misfolding
- Biological Research and Disease Studies
- Amyotrophic Lateral Sclerosis Research
- Phytochemicals and Antioxidant Activities
- Graphene and Nanomaterials Applications
- Phytochemistry and Biological Activities
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Tryptophan and brain disorders
- Salmonella and Campylobacter epidemiology
- CRISPR and Genetic Engineering
- Cardiac Imaging and Diagnostics
- Clusterin in disease pathology
- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- SARS-CoV-2 and COVID-19 Research
- Metal complexes synthesis and properties
Discovery Institute
2024-2025
Sanford Burnham Prebys Medical Discovery Institute
2024-2025
Arthritis and Rheumatic Disease Specialties
2025
Vietnam National University Ho Chi Minh City
2021-2024
Gachon University
2015-2024
UNSW Sydney
2020-2024
South Western Sydney Local Health District
2024
Ton Duc Thang University
2010-2021
Liverpool Hospital
2020-2021
Duy Tan University
2020
Abstract Alzheimer’s disease (AD) is the most common type of neurodegenerative dementia, but cause AD remained poorly understood. Many mutations in amyloid precursor protein ( APP ) and presenilin 1 2 PSEN1 PSEN2 have been reported as pathogenic causes early-onset (EOAD), which accounts for up to 5% all cases. In this study, we screened familiar/ de novo EOAD (n = 67) samples by next-generation sequencing (NGS) a 50-gene panel, included causative possible variants linked disorders....
Cancer is the second leading cause of death globally, and despite advances in drug development, it still necessary to develop new plant-derived medicines. Compared with using conventional chemical drugs decrease side effects induced by chemotherapy, natural herbal medicines have many advantages. The present study aimed discover potential cytotoxicity ethanol extract its derived fractions (chloroform, ethyl acetate, butanol, aqueous) Adenosma bracteosum Bonati. (A. bracteosum) on human large...
Alzheimer's disease (AD), Parkinson's (PD), frontotemporal dementia (FTD), amyotrophic lateral sclerosis (ALS), Huntington's (HD), and prion diseases have a certain degree of clinical, pathological, molecular overlapping. Previous studies revealed that many causative mutations in AD, PD, FTD/ALS genes could be found clinical familial sporadic AD. To further elucidate the missing heritability early-onset (EOAD), we genetically characterized Thai EOAD cohort by Next-Generation Sequencing (NGS)...
Indigofera zollingeriana Miq (I. zollingeriana) is a widely grown tree in Vietnam. It used to cure various illnesses. The purpose of this study was investigate the chemical constituents an I. extract and test its anticancer activity on hepatocellular cells (Huh7 HepG2). experimental results analysis bioactive compounds revealed that β-sitosterol (β-S) β-sitosterol-glucoside (β-SG) were main ingredients extract. Regarding activity, β-S β-SG found exhibit cytotoxic effects against HepG2 Huh7...
The number of patients with Alzheimer’s disease (AD) is rapidly increasing in Asia. Mutations the amyloid protein precursor (APP), presenilin-1 (PSEN1), and presenilin-2 (PSEN2) genes can cause autosomal dominant forms early-onset AD (EOAD). Although these have been extensively studied, variant classification remains a challenge, highlighting need to colligate mutations across populations. In this study, we performed genetic screening for APP, PSEN1, PSEN2 200 clinically diagnosed EOAD four...
Core-shell types of mesoporous silica nanoparticles (MSNs) with multimodal functionalities were developed for bio-imaging, controlled drug release associated external pH, and near-infrared radiation (NIR) stimuli, targeted effective chemo-photothermal therapeutics.We synthesized a core-shell type nanocarriers fluorescent imaging, stimuli-responsive release, magnetic separation, antibody targeting, therapeutics. Also, the biocompatibility, cellular uptake, cytotoxicity, photothermal therapy...
Ecofriendly and highly fluorescent carbon dot nanoassemblies have gained prominence for their diverse biological applications, with a focus on combating environmental human health problems. In this study, we prepared nitrogen-doped dots from the persimmon fruit (termed as "PCDs"), which was used source, via one-step hydrothermal reaction without any solvent. It is interesting to note that as-prepared PCDs were water-soluble because of numerous polar functional groups, such hydroxyl (-OH),...