A5100413004- Liver physiology and pathology
- Paleontology and Stratigraphy of Fossils
- Hedgehog Signaling Pathway Studies
- Nicotinic Acetylcholine Receptors Study
- Neurotransmitter Receptor Influence on Behavior
- Geology and Paleoclimatology Research
- Geological and Geophysical Studies
- Methane Hydrates and Related Phenomena
- Supercapacitor Materials and Fabrication
- Conducting polymers and applications
- Receptor Mechanisms and Signaling
- Genetic and Kidney Cyst Diseases
- Gastrointestinal motility and disorders
- Dental Health and Care Utilization
- MicroRNA in disease regulation
- Tryptophan and brain disorders
- Advancements in Battery Materials
- Hydrocarbon exploration and reservoir analysis
- Remote Sensing and LiDAR Applications
- Extracellular vesicles in disease
- Gut microbiota and health
- Marine and environmental studies
- Remote Sensing and Land Use
- Phytochemical Studies and Bioactivities
- Polysaccharides and Plant Cell Walls
Pusan National University
2014-2024
The Ohio State University
2022
Chungnam National University
2016
Korea Institute of Civil Engineering and Building Technology
2015
University of Colorado System
2013
Daegu Gyeongbuk Institute of Science and Technology
2012
Abstract Hedgehog (Hh) signalling regulates hepatic fibrogenesis. MicroRNAs (miRNAs) mediate various cellular processes; however, their role in liver fibrosis is unclear. Here we investigate regulation of miRNAs chronically damaged fibrotic liver. MiRNA profiling shows that expression miR-378 family members (miR-378a-3p, miR-378b and miR-378d) declines carbon tetrachloride (CCl 4 )-treated compared with corn-oil-treated mice. Overexpression miR-378a-3p, directly targeting Gli3 activated...
Mesenchymal stromal cells (MSCs) are considered as a promising therapeutic tool for liver fibrosis, main feature of chronic disease. Because small extracellular vesicles (sEVs) harboring variety proteins and RNAs known to have similar functions with their derived cells, MSC-derived sEVs carry out the regenerative capacities MSCs. Human tonsil-derived MSCs (T-MSCs) reported novel source MSCs, but effects on fibrosis remain unclear. In present study, we investigated T-MSC-derived fibrosis. The...
Radiation-induced fibrosis constitutes a major problem that is commonly observed in the patients undergoing radiotherapy; therefore, understanding its pathophysiological mechanism important. The Hedgehog (Hh) pathway induces proliferation of progenitors and myofibroblastic hepatic stellate cells (MF-HSCs) promotes epithelial-to-mesenchymal transition (EMT), thereby regulating repair response damaged liver. We examined normal liver to radiation injury. Male mice were sacrificed at 6 weeks 10...
Kombucha tea (KT) has emerged as a substance that protects the liver from damage; however, its mechanisms of action on fatty remain unclear. Therefore, we investigated potential role KT and underlying nonalcoholic disease (NAFLD). db/db mice were fed methionine/choline-deficient (MCD) diets for seven weeks treated vehicle (M + V) or K) with MCD four additional weeks. Histomorphological injury increased levels enzymes lipids evident in M V group, whereas these symptoms ameliorated K group....
Recently, the need to develop a robust three-dimensional (3D) cell culture system that serves as valuable in vitro tumor model has been emphasized. This should closely mimic growth behaviors observed vivo and replicate key elements characteristics of human tumors for effective discovery development anti-tumor therapeutics. Therefore, this study, we developed an 3D prostate cancer (PC) using marine collagen-based biomimetic scaffold. The displayed distinctive molecular profiles cellular...
Asthma is a chronic inflammatory disease characterized by T-lymphocyte and eosinophil infiltration, mucus overproduction airway hyper-responsiveness. The present study examined the therapeutic effects action mechanism of saponin-enriched extract Asparagus cochinchinensis (SEAC) on inflammation remodeling in an ovalbumin (OVA)-induced asthma model. To accomplish this, alterations nitric oxide (NO) level, inducible synthase (iNOS) cyclooxygenase-2 (COX-2) expression levels, as well variations...
Abstract Healthy livers have a remarkable regenerative capacity for reconstructing functional hepatic parenchyma after 70% partial hepatectomy (PH). Hepatocytes, usually quiescent in normal healthy livers, proliferate to compensate loss PH. However, the mechanism of hepatocyte involvement liver regeneration remains unclear. Hedgehog (Hh) pathway plays an important role tissue reconstitution by regulating epithelial-to-mesenchymal transition (EMT) disease. MicroRNA (miRNA) is involved cell...
Neurochemical alterations associated with behavioral responses induced by re-exposure to nicotine have not been sufficiently characterized in the dorsal striatum. Herein, we report on changes glutamate concentrations rat striatum after challenge. Nicotine challenge (0.4 mg/kg/day, subcutaneous) significantly increased extracellular up level observed repeated administration. This increase occurred parallel an locomotor and rearing activities. In contrast, acute administration withdrawal days...
Denitrification in the Arabian Sea is closely related to monsoon-induced upwelling and subsequent phytoplankton production surface water. The δ15N values of bulk sediments collected at Site U1456 International Ocean Discovery Program (IODP) Expedition 355 reveal orbital-scale denitrification history response Indian Monsoon. Age reconstruction based on correlation planktonic foraminifera (Globigerinoides ruber) δ18O with LR04 stack together shipboard biostratigraphic paleomagnetic data...
The molecular mechanisms of thymosin beta-4 (TB4) involved in regulating hepatic stellate cell (HSC) functions remain unclear. Therefore, we hypothesize that TB4 influences HSC activation through hedgehog (Hh) pathway. declined a siRNA-treated LX-2. suppression down-regulated both integrin linked kinase (ILK), an activator smoothened, and phosphorylated glycogen synthase 3 beta (pGSK-3B), inactive form GSK-3B degrading glioblastoma 2 (GLI2), followed by the decreased expression smoothened...
This study investigated the laxative effects of phlorotannins (Pt) derived from Ecklonia cava (E. cave) on chronic constipation by evaluating alterations in stool parameters, gastrointestinal motility, histopathological structure, mucin secretion, hormones, muscarinic cholinergic regulation, and fecal microbiota SD rats with loperamide (Lop)-induced subjected to Pt treatment. Stool-related parameters (including number, weight, water contents), length intestine were significantly enhanced...
맥문동(Liriope platyphylla)은 한국과 중국에서 전통적으로 당뇨, 비만, 뇌신경질환, 천식 등의 치료를 위해 사용 해온 치료제이다. 최근에 이들 맥문동으로부터 새로운 치료제를 개발하려는 노력이 활발히 진행 중이지만 아직도 유력한 치료후보제는 확보되지 않았다. 따라서 본 연구에서는 맥문동의 추출물을 이용하여 당뇨치료 제로서의 가능성을 평가하기 위하여 방법으로 10가지 후보물질을 추출하고 이들의 독성과 효능을 평가하였다. 그 결과 추출물 중에서 LP9M80-H가 인슐린 분비를 가장 많이 촉진하였고 다음으로는 LP-H, LP-M, LP-E과 LP9M80-C 순서로 촉진을 하였으나 나머지는 촉지하지 못하였다. 그러나 물질은 촉진하는 농도에서 강한 세포 독성을 나타내었다. 물질 효능이 좋은 LP9M80-H의 치료용 최적농도를 설정하였으며, 대략 100-25 ug/ml가 최적농도로 결정되었다. 이러한 결과는 맥문동 췌장 <TEX>$\beta$</TEX>-세포의 분비능을...
Liriope platyphylla is a medical herb that has long been used in Korea and China to treat cough, sputum, neurodegenerative disorders, obesity, diabetes. The aims of this study were determine the antidiabetic antiobesity effects aqueous extract L. (AEtLP) through glucose lipid regulation both pre-diabetes obesity stage type II diabetes model. Two concentrations AEtLP orally administrated OLETF (Otsuka Long-Evans Tokushima Fatty) rats once day for 2 weeks, after which changes metabolism fat...
This study aimed to analyse the association of self-perceived oral health status (OHS) and functions with clinical OHS in Korean adults aged 35⁻54 years. The was designed as a cross-sectional using data from Fourth Korea National Health Nutrition Examination Survey (2007⁻2009). A total 6605 subjects years who completed examination questionnaires were included. An clinically determined confirmed by complex-samples general linear model. Data on socioeconomic variables, i.e., household income...
Nicotine, a nicotinic acetylcholine receptor agonist, produces the reinforcing effects of tobacco dependence by potentiating dopaminergic and glutamatergic neurotransmission. Non-nicotine alkaloids in also contribute to activating cholinergic system. However, neurotransmission dorsal striatum associated with behavioral changes response cigarette smoking has not been investigated. In this study, authors investigated alterations glutamate levels rat related after repeated administration smoke...