A5100423436- Topic Modeling
- Biomedical Text Mining and Ontologies
- Advanced Graph Neural Networks
- Bioinformatics and Genomic Networks
- Photochemistry and Electron Transfer Studies
- Video Surveillance and Tracking Methods
- Natural Language Processing Techniques
- Spectroscopy and Quantum Chemical Studies
- Semantic Web and Ontologies
- Free Radicals and Antioxidants
- Immunotherapy and Immune Responses
- Advanced Vision and Imaging
- Advanced Text Analysis Techniques
- Microbial Metabolic Engineering and Bioproduction
- 3D Surveying and Cultural Heritage
- Advanced Neural Network Applications
- T-cell and B-cell Immunology
- Computational Drug Discovery Methods
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- Machine Learning in Bioinformatics
- Data Quality and Management
- Protein Structure and Dynamics
- Biodiesel Production and Applications
- Toxin Mechanisms and Immunotoxins
Beijing Tongren Hospital
2025
Capital Medical University
2025
Qingdao University
2022-2024
Harbin Engineering University
2023-2024
Affiliated Hospital of Qingdao University
2022-2024
Hangzhou Institute of Applied Acoustics
2024
Jilin University
2014-2023
McGill University
2023
Fudan University Shanghai Cancer Center
2023
Shanghai Medical College of Fudan University
2023
Health knowledge graph provides an ideal technical means to integrate heterogeneous data resources and enhance knowledge-based services. There are many challenges for the construction of health such as complex concepts relationships, various medical standards, structures, poor quality, highly accurate interpretable services, etc. In this paper, firstly, we propose Knowledge Graph Builder (HKGB), end-to-end platform which could be used construct disease-specific extensible graphs from...
OncoboxPD (Oncobox pathway databank) available at https://open.oncobox.com is the collection of 51 672 uniformly processed human molecular pathways. Superposition all pathways formed interactome graph protein-protein interactions and metabolic reactions containing 361 654 64 095 participants. Pathways are classified by biological processes, each node algorithmically functionally annotated specific activator/repressor role. This enables online calculation statistically supported activation...
The multiple proton transfer reactions of 3-hydroxypyridine-(H<sub>2</sub>O)<sub>3</sub>have been demonstrated, and a perfect cycle has revealed in the ground excited states.
T-helper (Th) 22 and Th17 cells are involved in the pathogenesis of autoimmune diseases. However, their roles Graves'disease (GD) unclear. This study is aimed at examining frequency peripheral blood Th22, Th17, Th1 levels plasma IL-22, IL-17, IFN-γ patients with GD. A total 27 new onset GD gender- age-matched healthy controls (HC) were examined for by flow cytometry. The concentrations enzyme-linked immunosorbent assay. serum TSHR antibodies (A-TSHR), free triiodothyronine (FT3), thyroxine...
Background T follicular helper (TFH) cells are a special subpopulation of and can regulate humoral immune responses. This study examined whether the frequency CD4+CXCR5+ TFH could be associated with active immunity in chronic hepatitis B (CHB) patients. Methodology Findings The frequencies peripheral blood cells, inducible cell costimulator (ICOS), and/or programmed death 1 (PD-1) positive immune-active (IA), immune-tolerant (IT) CHB, healthy controls (HC) were characterized by flow...
Aldo-keto reductase family 1 member C3 has recently been regarded as a potential therapeutic target in castrate-resistant prostate cancer. Herein, we investigated whether berberine delayed the progression of cancer by reducing androgen synthesis through inhibition C3. Cell viability and cellular testosterone content were measured cells. mRNA protein level detected RT-PCR Western bolt analyses, respectively. Computer analysis with AutoDock Tools explored molecular interaction We found that...
Circular RNAs (circRNAs), a novel subgroup of non-coding (ncRNAs), have been reported in human cancers due to their significant regulatory roles. CircRNA Hippocampus Abundant Transcript 1 (circHIAT1) has studied clear cell renal carcinoma. However, whether it can regulate the tumorigenesis hepatocellular carcinoma (HCC) remains unclear. The expression level circHIAT1 HCC samples and lines was measured by qRT-PCR analysis. CircHIAT1 expressed at significantly low cancerous samples. Based on...
Echinacoside is a natural compound with potent reactive oxygen species (ROS)-scavenging and anti-oxidative bioactivities, which protect cells from oxidative damages. As cancer are often under intense stress, we therefore tested if treatment would promote development. Surprisingly, found that significantly inhibited the growth proliferation of panel cell lines. Treatment human SW480 resulted in marked apoptosis cycle arrest, together significant increase active caspase 3 cleaved PARP,...
Region proposal network (RPN) based object detection, such as Faster Regions with CNN (Faster R-CNN), has gained considerable attention due to its high accuracy and fast speed. However, it room for improvements when used in special application situations, the on-board vehicle detection. Original RPN locates multiscale anchors uniformly on each pixel of last feature map classifies whether an anchor is part foreground or background one map. The receptive field fixed original faster R-CNN does...
Shrimp-derived allergen has a serious impact on people's health. Chitosan oligosaccharide (COS) anti-allergic action but its function shrimp allergen-induced allergy and related molecular mechanisms remain unclear.COS degrees of polymerization (DP) were selected to interact with tropomyosin (TM) IgE was measured. A mouse model food established by receiving TM intraperitoneally. The models treated different concentrations COS. Fecal serum histamine, IgE, IgG1 IgG2a, inflammatory cytokines...
Early and accurate detection of hepatocellular carcinoma (HCC) is essential to improve the prognosis patients reduce morbidity surgical therapy. Glypican‐3 (GPC3) a protein abnormally expressed in HCC that has been identified as serological histochemical marker. A novel peptide specifically recognizes GPC3 will facilitate early guide treatment strategy. Herein, phage display screening technology utilized obtain binding (GBP) using cells expressing varying abundances. After seven rounds...