A5100358461- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Nanoplatforms for cancer theranostics
- Microbial infections and disease research
- RNA Interference and Gene Delivery
- NF-κB Signaling Pathways
- Immunotherapy and Immune Responses
- Bacteriophages and microbial interactions
- Nanoparticle-Based Drug Delivery
- Phagocytosis and Immune Regulation
- Advanced Drug Delivery Systems
- Aquaculture disease management and microbiota
- Herpesvirus Infections and Treatments
- Toxoplasma gondii Research Studies
- Animal Virus Infections Studies
- Pharmacological Effects of Natural Compounds
- interferon and immune responses
- Animal Disease Management and Epidemiology
- Immune cells in cancer
- Biochemical Analysis and Sensing Techniques
- Fluid Dynamics and Thin Films
- Ocular Oncology and Treatments
- Signaling Pathways in Disease
- Glass properties and applications
- Quantum and electron transport phenomena
Yancheng Third People's Hospital
2025
Nanjing Medical University
2025
Jiangsu Vocational College of Medicine
2025
Nantong University
2025
Sichuan University
2025
State Key Laboratory of Oral Diseases
2025
Shandong First Medical University
2022-2023
Shandong Provincial Hospital
2022-2023
Anhui University of Technology
2014-2022
Jilin University
2017-2022
CCR9+ T cells have an increased potential to be activated and therefore may mediate strong antitumor responses. Here, we found, however, that CCL25, the only chemokine for cells, is not expressed in human or murine triple-negative breast cancers (TNBCs), raising a hypothesis intratumoral delivery of CCL25 enhance immunotherapy TNBCs. We first determined whether this approach can CD47-targeted using tumor acidity-responsive nanoparticle system (NP-siCD47/CCL25) sequentially release protein...
Immunotherapy has been successfully used in the treatment of multiple malignancies, but clinical studies revealed low response rates. Thus, development new effective immunotherapeutic modalities is urgently needed. Successfully inducing tumor cell death with enhanced antigenicity important for expansion and differentiation tumor-specific CD8+ cytotoxic T lymphocytes. Cationic liposome/DNA complexes (CLN/DNA), which usually have obvious effects, may improve antitumor immunity through...
Ulcerative colitis (UC) is a chronic, nonspecific, relapsing inflammatory bowel disease. Metformin has pleiotropic effects including anti-inflammatory properties and notable impact on the gut microbiome. γδT17 cells play crucial role in initiating maintaining intestinal inflammation. The effect of metformin remains unclear. This study aims to explore connection between metformin-mediated ameliorated response mice cell activity. inhibition amelioration was evaluated mice. differentiation...
Achieving precise restoration of tooth function and personalized natural esthetics has always been a significant challenge in direct restorative dentistry. The traditional techniques are limited by the subjective operations dentists, resulting high technical sensitivity, long operation time, unpredictable results, making it difficult to meet patients' demands for outcomes. An innovative flowable resin injection technique was introduced this study. By combining digital design with guides,...
We investigate the stability, bonding, and geometric structure of recently discovered metallocarbohedrenes by use density-functional calculations. It is found that previously proposed ${\mathit{T}}_{\mathit{h}}$ dodecahedron dynamically unstable. Instead, a new, stable, more strongly bound with ${\mathit{D}}_{2\mathit{d}}$ symmetry found. find strong interactions between C-C Ti-C covalent bonding. The stability has been verified calculating vibrational frequencies. infrared spectrum...
Immunotherapy has shown promising results in multiple malignancies. However, there are still significant challenges cancer immunotherapy including the powerful immunosuppressive tumor microenvironment and adverse off-target side effects. Nanomaterials with defined physico-biochemical properties versatile drug delivery platforms that may address these key technical faced by immunotherapy. Here, a acidity-responsive biomacromolecule system was designed to intratumorally deliver an...
Gastric cancer most commonly occurs in East Asia, and China accounts for more than half the of world's gastric burden. Despite efficacy chemotherapy patients, this treatment leads to significant patient inconvenience, toxicity cost. The present study aimed assess a non-toxic agent, glabridin, as future chemotherapeutic approach treating cancer. Using cell proliferation, apoptosis, invasion, colony formation assays, it was determined that glabridin alone, or combination with 5-fluorouracil...
Oral therapy utilizing engineered microorganisms has shown promise in the treatment of many diseases. By microencapsulation, viable cells can overcome harsh gastrointestinal (GI) environment and secrete needed therapeutics into gut. These should be encased without escaping GI tract for safety concerns, thus robust microcapsule membrane is requisite. This paper examined performance a novel using dynamic simulated human model. Results showed that genipin cross-linked alginate-chitosan (GCAC)...
Gold nanoparticles (AuNPs) have been extensively explored as a drug carrier and widely used to provide advanced biomedical research tools in diagnostic imaging therapy for cancer. Although the mononuclear phagocyte system immune are known play main roles clearance of AuNPs during circulation, particle distribution within cells under condition dysfunction caused by tumor growth has not thoroughly studied. Here, cellular Cy5 labeled with diameters 5, 30 50 nm is characterized populations...
Cancer immunotherapy using immune checkpoint blockade has become an attractive treatment option for patients with different cancers. JQ1, indirect inhibitor of MYC, enhances antitumor responses by regulating the expression programmed death-ligand 1 (PD-L1) and cluster differentiation 47 (CD47) in tumor cells; however, its role downregulating CD47 remains elusive. The present study revealed that JQ1 failed to downregulate and, when used at high concentrations, it unexpectedly upregulated...
Methyl gallate (MG), a polyphenolic compound found in plants, is widely used traditional Chinese medicine. MG known to alleviate several cancer symptoms. However, most studies that have reported the antitumor effects of done so at cellular level, and inhibitory effect therapeutic mechanism hepatocellular carcinoma (HCC) not been extensively explored vivo. We aimed understand HCC vitro MTT colony formation assays were determine impact on proliferation human cell line, BEL-7402; wound healing...
The aim of this study was to investigate the presence and genetic environment multiresistance gene cfr in Pasteurella multocida avian origin from China. A total 113 P. isolates were collected sick poultries (ducks, chickens geese) 2003 2016 Southern China screened for by PCR. cfr-carrying strains subjected antimicrobial susceptibility testing, S1 nuclease PFGE blot hybridisation, conjugative transfer analysis gene. Among isolates, FJ6671 FJ6683 Muscovy duck harboured presented a...
Aromatic amino acid hydroxylase 2 (AAH2) is a bradyzoite-specific upregulated protein that may alter host behaviour by altering the dopaminergic pathway. To better understand role of parasite's AAH2 in host-parasite interactions, we generated an fluorescent marker strain T. gondii using TALEN technique. We gondii, which was designated PRU/AAH2-eGFP, This stably expressed pyrimethamine resistance for screening and enhanced green (eGFP)-tagged bradyzoite stage. The conversion PRU/AAH2-eGFP...