A5080759263- Ubiquitin and proteasome pathways
- Eosinophilic Esophagitis
- IL-33, ST2, and ILC Pathways
- Cancer-related Molecular Pathways
- Immune Cell Function and Interaction
- Animal Disease Management and Epidemiology
- T-cell and Retrovirus Studies
- Cancer Mechanisms and Therapy
- Cancer, Hypoxia, and Metabolism
- Estrogen and related hormone effects
- Tannin, Tannase and Anticancer Activities
- Peptidase Inhibition and Analysis
- NF-κB Signaling Pathways
- Food Quality and Safety Studies
- interferon and immune responses
- Computational Drug Discovery Methods
- Pluripotent Stem Cells Research
- Immune Response and Inflammation
- 3D Printing in Biomedical Research
- Sexual function and dysfunction studies
- Aquaculture disease management and microbiota
- Hormonal and reproductive studies
- Retinopathy of Prematurity Studies
- Mindfulness and Compassion Interventions
- Bioactive Compounds and Antitumor Agents
Xinxiang Medical University
2011-2023
Guangdong Pharmaceutical University
2007-2023
Chengdu University
2020
Target (United States)
2018
Jiangsu University
2017
Chengdu University of Traditional Chinese Medicine
2010-2011
The IL-33-type 2 innate lymphoid cell (ILC2) axis has an important role in tissue homeostasis, inflammation, and wound healing. However, the relative importance of this immune pathway for immunotherapy against inflammation damage remains unclear. Here, we show that treatment with recombinant mouse IL-33 prevented renal structural functional injury reduced mortality mice subjected to ischemia-reperfusion (IRI). Compared control-treated IRI mice, IL-33–treated had increased levels IL-4 IL-13...
IL-25 is an important immune regulator that can promote Th2 response-dependent immunity, inflammation, and tissue repair in asthma, intestinal infection, autoimmune diseases. In this study, we examined the effects of renal ischemic/reperfusion injury (IRI). Treating IRI mice with significantly improved function reduced injury. Furthermore, treatment increased levels IL-4, IL-5, IL-13 serum kidney promoted induction alternatively activated (M2) macrophages kidney. Notably, also frequency type...
Article9 October 2020Open Access Transparent process IL-10 producing type 2 innate lymphoid cells prolong islet allograft survival Qingsong Huang Henan Key Laboratory of Immunology and Targeted Drugs, School Medicine, Xinxiang Medical University, Xinxiang, China Search for more papers by this author Xiaoqian Ma Centre Transplant Renal Research, Westmead Institute The University Sydney, NSW, Australia Cell Transplantation Gene Therapy, Third Xiangya Hospital Central South Changsha, Yiping...
Breast cancer is one of the most common malignancies worldwide, while luminal types (ERα positive) accounts for two third all breast cases.Although ERα positive could be effective controlled by endocrine therapy, patients will develop resistance, which becomes a headache clinical issue field.Endocrine resistance caused multiple pathway disorders, dys-regulation signaling might critical factor, makes it urgent and important to reveal potential molecular mechanism signaling.In our current...
Abstract Chloride channel‐3 (ClC‐3), a member of the ClC family voltage‐gated Cl − channels, is involved in resistance tumor cells to chemotherapeutic drugs. Here, we report new mechanism for ClC‐3 mediating multidrug (MDR). was highly expressed P‐glycoprotein (P‐gp)‐dependent human lung adenocarcinoma cell line (A549)/paclitaxel (PTX) and breast carcinoma (MCF‐7)/doxorubicin (DOX) resistant cells. Changes expression resulted development drug formerly drug‐sensitive A549 or MCF‐7 cells,...
Abstract Background Breast cancer is the most common in women worldwide. More than 70% of breast cancers are estrogen receptor (ER) alpha positive. Compared with ER alpha-negative cancer, which more aggressive and has a shorter survival time, alpha-positive could benefit from endocrine therapy. Selective modulators, such as tamoxifen, widely used Approximately half patients will eventually develop resistance, making it major clinical challenge Thus, decoding throughput signaling, including...
Methyl gallate (MG), a polyphenolic compound found in plants, is widely used traditional Chinese medicine. MG known to alleviate several cancer symptoms. However, most studies that have reported the antitumor effects of done so at cellular level, and inhibitory effect therapeutic mechanism hepatocellular carcinoma (HCC) not been extensively explored vivo. We aimed understand HCC vitro MTT colony formation assays were determine impact on proliferation human cell line, BEL-7402; wound healing...
Abstract Breast cancer is the most common malignancy in women on a global scale. It can generally be divided into four main categories, of which estrogen receptor ER-positive breast accounts for cases. RBCK1 protein an E3 ubiquitin ligase containing UBL, NZF, and RBR domains. well known to exhibit abnormal expression tumors, making it valuable diagnostic marker drug target. Additionally, studies have confirmed that cancer, about 25 40% tumors appear as visible hypoxic regions, while hypoxia,...
Streptococcus pneumoniae is the most common pathogenic bacterium of pneumonia and can cause death. Here, we examined impact Baicalein on mouse mortality caused by infection. protected mice from pneumoniae-induced deaths. reduced alveolocapillary membrane permeability, lung infiltration inflammatory cells, cytokine production pulmonary cell apoptosis. These evidences show that useful in therapy a severe form
FGF signaling pathway is imperative for definitive endoderm (DE) differentiation from human embryonic stem cells (hESCs), which always accompanies an epithelial-to-mesenchymal transition (EMT) process. However, whether there association between and the EMT during DE formation in vitro has remained elusive. In present study, we identify that several family members were significantly activated of hESCs toward DE. Inhibition by efficient selective inhibitor BGJ398 abolishes both induction...
// Qingsong Huang 1, 2, 3, * , Zhiguo Niu Jingxian Han 4 Xihong Liu 2 Zhuangwei Lv 5 Huanhuan Li Lixiang Yuan Xiangping 6 Shuming Sun 1 Hui Wang 3 and Xinxiang School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, China Research Center for Immunology, Laboratory Medical Xinxiang, Henan, Collaborative Innovation Molecular Diagnosis The 7th Hospital Zhengzhou City, Zhengzhou, Third Affiliated Of Luoyang Orthopedic-Traumatological Hospital, These authors contributed equally to this work...
Chemotherapy is widely used in a variety of solid tumors, such as lung cancer, gastric cancer and breast cancer. The genotoxic drugs, cisplatin, suppress progression either by inhibition cell proliferation or facilitating apoptosis. However, the chemotherapy resistance remains an urgent challenge therapy, especially advanced stages. Several studies showed that activation pro-survival pathways, PI3K-AKT, participated mediating resistance. insights into molecular mechanisms for underlying are...
Although type 2 innate lymphoid cells (ILC2s) were originally found to be liver-resident lymphocytes, the role and importance of ILC2 in liver injury remains poorly understood. In current study, we sought determine whether is an important regulator hepatic ischaemia/reperfusion (IRI).ILC2-deficient mice (ICOS-T or NSG) genetically modified ILC2s used investigate murine IRI. Interactions between eosinophils macrophages studied coculture. The human was assessed immunocompromised mouse model...
A definitive endodermal cell lineage is a prerequisite for the efficient generation of mature endoderm derivatives that give rise to organs, such as pancreas and liver. We previously reported induction mesenchymal cells depends on autocrine TGF-β signaling pharmacological blockage by Repsox disrupts specification. The arises from primitive streak, which largely signaling. If pathway blocked Repsox, fate after streak so-far unknown. report here, an induced cell-population contained many...
Breast cancer is the most common women malignancy worldwide, while estrogen receptor alpha positive type accounts for two third of all breast cancers. Although ER could be effectively controlled by endocrine therapy, more than half cases develop resistance, making it an important clinical issue in treatment. Thus, decoding detailed mechanism, which controls signaling activation and protein stability, great importance improvement therapy. Several zinc finger proteins were shown to mediate...