A5101861538- Child and Adolescent Psychosocial and Emotional Development
- Hepatitis B Virus Studies
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Attachment and Relationship Dynamics
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Cancer-related Molecular Pathways
- Cancer-related gene regulation
- Ferroptosis and cancer prognosis
- Radiomics and Machine Learning in Medical Imaging
- Bullying, Victimization, and Aggression
- Epigenetics and DNA Methylation
- Ubiquitin and proteasome pathways
- Genetic diversity and population structure
- Colorectal Cancer Treatments and Studies
- Family Dynamics and Relationships
- Gastric Cancer Management and Outcomes
- Plant and Fungal Species Descriptions
- Maternal Mental Health During Pregnancy and Postpartum
- Hepatocellular Carcinoma Treatment and Prognosis
- RNA Research and Splicing
- Cancer Immunotherapy and Biomarkers
- Inflammatory Biomarkers in Disease Prognosis
- Plant and animal studies
University of Science and Technology of China
2021-2025
Xinyang Normal University
2018-2025
South China Normal University
2022-2024
Beijing Institute of Genomics
2021-2024
Northwest A&F University
2021-2024
Shanghai Center For Bioinformation Technology
2024
Chinese Academy of Sciences
2021-2024
University of Chinese Academy of Sciences
2024
Anhui Provincial Hospital
2023
Anhui Medical University
2023
Microwaves are electromagnetic waves of specific frequencies (300 MHz-3000 GHz), whereas ultrasonic is mechanical frequencies. Microwave and technology as a new processing method has been widely used in food fields. Combined microwave exploited by researchers an improvement technique successfully applied such thawing, drying, frying, extraction, sterilization. This paper overviews the principle characteristics ultrasonic- microwave-assisted techniques, particularly their combinations, design...
Purpose: Pancreatic ductal adenocarcinoma (PDAC) is a malignant disease with poor prognosis. One prominent aspect of PDAC that contributes to its aggressive behavior altered cellular metabolism. The aim this study was characterize the oncogenic effects ubiquinol-cytochrome c reductase core protein I (UQCRC1), key component mitochondrial complex III, in development and assess potential as therapeutic target for PDAC. Experimental Design: expression UQCRC1 human tissues...
Abstract Irritable bowel syndrome is a functional gastrointestinal disorder characterized by chronic visceral pain with complex etiology and difficult treatment. Accumulated evidence has confirmed that the sensitization of central nervous system plays an important role in development pain, whereas exact mechanisms action neural pathways remain largely unknown. In this study, distinct circuit was identified from paraventricular hypothalamic (PVH) to ventral lateral septal (LSV) region. This...
Abstract Background Theaceae, comprising 300 + species, holds significance in biodiversity, economics, and culture, notably including the globally consumed tea plant. Stewartia gemmata, a species of earliest diverging tribe Stewartieae, is critical to offer insights into Theaceae's origin evolutionary history. Result We sequenced complete organelle genomes gemmata using short/long reads sequencing technologies. The chloroplast genome (158,406 bp) exhibited quadripartite structure large...
174 Background: Fruquintinib and TAS-102 are two globally recognized standard therapies for mCRC patients who have previously undergone chemotherapy. A phase II exploratory study suggested that the combination of fruquintinib could prolong progression-free survival (PFS) overall (OS) in these patients. However, benefits sometimes limited due to tolerability issues associated with continuous dosing. This aimed investigate efficacy safety intermittent administration combined as a third-line...
Orphan genes play crucial roles in diverse biological processes, but the evolutionary trajectories and functional divergence remain largely unexplored. The Theaceae family, including economically culturally important tea plant, offers a distinctive model to examine these aspects. Here, we integrated Nanopore long-read sequencing, Illumina short-read Hi-C methods decode pseudo-chromosomal genome assembly of Stewartia sinensis, from earliest-diverging tribe Theaceae, spanning 2.95 Gb....
Objective: To investigate the value of a machine learning model that integrates radiomics features and peripheral blood inflammatory markers in predicting prognosis patients with unresectable esophageal squamous cell carcinoma (ESCC) receiving PD-1 inhibitor combined concurrent chemoradiotherapy. Methods: A retrospective collection was conducted involving 105 ESSC who received inhibitors chemoradiotherapy at First Affiliated Hospital University Science Technology China from January 2020 to...
Abstract Tumor cells evolve strong antioxidant capacities to counteract the abnormal high level of reactive oxygen species (ROS) in tumor microenvironment. Glutamate-cysteine ligase catalyzing subunit (GCLC) for synthesis glutathione (GSH) represents key enzyme maintain redox homeostasis cells, however, whether its activity is regulated by posttranslational modifications, such as succinylation, remains be clarified. Here, we demonstrate existence succinylation modification on GCLC vitro and...
Abstract Hepatitis B virus (HBV) infection has been reported to be associated with non‐Hodgkin lymphoma (NHL). However, the evidence is limited seroepidemiological study. There a lack of showing HBV and integration in NHL cells. Here, we that Shanghai area, positive rates serum HBsAg (OR: 3.11; 95% CI: 2.20‐4.41) HBeAg 3.99; 1.73‐9.91) were significantly higher patients NHL. HBsAg, HBcAg DNA detected 34.4%, 45.2% 47.0% tissues, respectively. Furthermore, by using high‐throughput viral...
This study aims to develop a pretreatment and drying process for kidney beans improve their cooking efficiency. Hot air (HD) microwave hot rolling (MHRD) were analyzed the of pre-cooked beans, effect on structure gelatinization properties starch investigated. The result indicated that time was significantly reduced by approximately 27% (p < 0.05) with increase temperature 10 °C in HD-processed material. Based incorporation radiation, further decreased 2.5 times at same temperature....
Antimicrobial genes are found in all classes of life. To efficiently isolate these genes, we used Bacillus subtilis and Escherichia coli as target indicator bacteria transformed them with cDNA libraries. Among thousands expressed proteins, candidate proteins played antimicrobial roles from the inside (internal effect), contributing to sensitivity (much more than external effect working outside cells) high throughput ability screening. We that B. is efficient reliable E. coli. Using...
Tea is one of the three most popular nonalcoholic beverages globally and has extremely high economic cultural value. Currently, classification, taxonomy, evolutionary history tea family are largely elusive, including phylogeny, divergence, speciation, diversity. For understanding dynamics species diversity in Theaceae, a robust phylogenetic framework based on 1785 low-copy 79,103 multi-copy nuclear genes from 91 plant genomes transcriptome datasets had been reconstructed. Our results...
This study explores the impact of positive parenting on adolescents' life satisfaction and mediating role parent-adolescent attachment, based family systems theory attachment theory. The sample included 5,047 adolescents (2,353 males, 2,694 females) with a mean age 16.65 (SD = 1.21) from Henan Province, China. used Positive Parenting Scale, Inventory Parent Peer Attachment Satisfaction Life Scale to survey adolescents. results showed that: (1) father's positively predicted adolescent...
Building on Beck's cognitive model of depression, this study examined the link between harsh parenting and adolescent depression via rumination. In addition, moderating effect school support. A survey 4991 high students in China was conducted utilizing Harsh Parenting Scale, Rumination Responses Beck Depression Inventory, The Multidimensional Scale Perceived Social Support. results unveiled a positive association depression. Furthermore, it observed that rumination partially mediated...
Abstract Chloride channel‐3 (ClC‐3), a member of the ClC family voltage‐gated Cl − channels, is involved in resistance tumor cells to chemotherapeutic drugs. Here, we report new mechanism for ClC‐3 mediating multidrug (MDR). was highly expressed P‐glycoprotein (P‐gp)‐dependent human lung adenocarcinoma cell line (A549)/paclitaxel (PTX) and breast carcinoma (MCF‐7)/doxorubicin (DOX) resistant cells. Changes expression resulted development drug formerly drug‐sensitive A549 or MCF‐7 cells,...
The ubiquitin-proteasome system (UPS) is a regulated mechanism of intracellular protein degradation and turnover, its dysfunction associated with various diseases including cancer. UBR5, an E3 ubiquitin ligase, emerging as important regulator the UPS in cancers, but role pancreatic cancer poorly understood. Here, we show that UBR5 significantly upregulated tissues. High expression correlated increased lymph node metastasis poor survival patients. loss-of-function gain-of-function studies...
Juglans regia is a world-famous woody oil plant, whose yield and quality are affected by drought stress. Ethylene-responsive factors (ERFs) play vital role in plant stress response. In current study, to comprehend the walnut molecular mechanism of response, an ERF transcription factor was clarified from J. (JrERF2-2) its potential function clarified. The results showed that JrERF2-2 could be induced significantly drought. transgenic Arabidopsis over-expression displayed enhanced growth,...
The objective of this study is to investigate the potential association between change in body composition before and after cetuximab-based therapy prognostic outcomes among individuals diagnosed with advanced colorectal cancer. A retrospective analysis was undertaken on a cohort 81 patients RAS wild-type (WT) metastatic cancer (mCRC) who were treated first-line therapy. To assess relevant parameters, quantitative computed tomography (QCT) scans conducted both cetuximab treatment. These...
Cadherin 13 (CDH13) is an atypical cadherin that exerts tumor-suppressive effects on cancers derived from epithelial cells. Although the CDH13 promoter frequently hypermethylated in pancreatic cancer (PC), direct impact of PC unknown. Accordingly, expression cell lines and paired tissues was examined by immunohistochemistry, quantitative real-time PCR western blotting. Our findings showed downregulated lines. Moreover, proliferation, migration invasion were detected CCK-8 assay, transwell...