A5017162527- Immune Cell Function and Interaction
- Tryptophan and brain disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuropeptides and Animal Physiology
- Antimicrobial Peptides and Activities
- RNA Interference and Gene Delivery
- Reproductive System and Pregnancy
- T-cell and B-cell Immunology
- Grit, Self-Efficacy, and Motivation
- Immunotherapy and Immune Responses
- Mitochondrial Function and Pathology
- Wnt/β-catenin signaling in development and cancer
- Adipose Tissue and Metabolism
- Immune cells in cancer
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer Immunotherapy and Biomarkers
- Monoclonal and Polyclonal Antibodies Research
- Liver Disease Diagnosis and Treatment
- Cancer-related gene regulation
- Cancer, Hypoxia, and Metabolism
- Optimism, Hope, and Well-being
- Kruppel-like factors research
Renji Hospital
2017-2023
Shanghai Jiao Tong University
2017-2023
Shanghai Cancer Institute
2017-2023
State Key Laboratory of Oncogene and Related Genes
2017-2023
Abstract Mice housed in an enriched environment display a tumor-resistant phenotype due to eustress stimulation. However, the mechanisms underlying environment–induced protection against cancers remain largely unexplained. In this study, we observed significant antitumor effect induced by murine pancreatic cancer and lung models. This remained intact T/B lymphocyte-deficient Rag1−/− mice, but was nearly eliminated natural killer (NK) cell–deficient Beige mice or antibody-mediated...
Background and Aims: The liver has the unique ability of regeneration, which is extremely important for restoring homeostasis after injury. Although clinical observations have revealed an association between psychological stress liver, whether a causal influence on regeneration remains markedly less defined. Approach Results: Rearing rodents in enriched environment (EE) can induce eustress or positive stress. Herein, EE-induced was found to significantly enhance partial hepatectomy carbon...
Purpose: Pancreatic ductal adenocarcinoma (PDAC) is a malignant disease with poor prognosis. One prominent aspect of PDAC that contributes to its aggressive behavior altered cellular metabolism. The aim this study was characterize the oncogenic effects ubiquinol-cytochrome c reductase core protein I (UQCRC1), key component mitochondrial complex III, in development and assess potential as therapeutic target for PDAC. Experimental Design: expression UQCRC1 human tissues...
Cadherin 13 (CDH13) is an atypical cadherin that exerts tumor-suppressive effects on cancers derived from epithelial cells. Although the CDH13 promoter frequently hypermethylated in pancreatic cancer (PC), direct impact of PC unknown. Accordingly, expression cell lines and paired tissues was examined by immunohistochemistry, quantitative real-time PCR western blotting. Our findings showed downregulated lines. Moreover, proliferation, migration invasion were detected CCK-8 assay, transwell...
Abstract CD40 agonistic antibody is emerging as a front-line immunotherapy for patients with cancer. However, despite its remarkable curative effects, serious immune-related adverse reactions limit the clinical application of agonists. Crosslinking-dependent activation one promising approaches to diminish effects Agonistic stimulation on antigen presenting cells (APCs) not only promotes T cells, but also results in PD-L1 upregulation APCs, thus creating negative feedback loop dampen...
<p>Supplementary Materials and Methods.</p>
<p>Influence of EE on NK population in the peripheral blood and spleen tumor-bearing mice.</p>
<p>EE increases the expression levels of INF-gamma and granzyme B in NK cells.</p>
<p>EE prevents experimental lung metastases of murine melanoma cells.</p>
<p>EE decreases serum leptin levels in wild-type and Beige mice.</p>
<p>EE does not appear to influence the expression levels of ligands NKG2D and CCR5 in tumors.</p>
<p>Exposure to EE reduces anxiety-like behavior, decreases body weight, and increases food intake in mice.</p>
<p>EE does not appear to influence the expression levels of ligands NKG2D and CCR5 in tumors.</p>
<p>Exposure to EE reduces anxiety-like behavior, decreases body weight, and increases food intake in mice.</p>
<p>Influence of EE on NK population in the peripheral blood and spleen tumor-bearing mice.</p>
<p>EE increases the expression levels of INF-gamma and granzyme B in NK cells.</p>
<p>Supplementary Materials and Methods.</p>
<p>EE decreases serum leptin levels in wild-type and Beige mice.</p>
<p>EE prevents experimental lung metastases of murine melanoma cells.</p>
<div>Abstract<p>Mice housed in an enriched environment display a tumor-resistant phenotype due to eustress stimulation. However, the mechanisms underlying environment–induced protection against cancers remain largely unexplained. In this study, we observed significant antitumor effect induced by murine pancreatic cancer and lung models. This remained intact T/B lymphocyte-deficient Rag1<sup>−/−</sup> mice, but was nearly eliminated natural killer (NK) cell–deficient...
<div>Abstract<p>Mice housed in an enriched environment display a tumor-resistant phenotype due to eustress stimulation. However, the mechanisms underlying environment–induced protection against cancers remain largely unexplained. In this study, we observed significant antitumor effect induced by murine pancreatic cancer and lung models. This remained intact T/B lymphocyte-deficient Rag1<sup>−/−</sup> mice, but was nearly eliminated natural killer (NK) cell–deficient...