A5019609523- Acute Myeloid Leukemia Research
- RNA modifications and cancer
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- RNA and protein synthesis mechanisms
- Lymphoma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Enzyme Structure and Function
- Cancer Genomics and Diagnostics
- Immune Cell Function and Interaction
- Viral-associated cancers and disorders
- Hematopoietic Stem Cell Transplantation
- Acute Lymphoblastic Leukemia research
- Epigenetics and DNA Methylation
- Cancer Cells and Metastasis
- Chronic Myeloid Leukemia Treatments
- Coronary Interventions and Diagnostics
- Multiple Myeloma Research and Treatments
- Cancer-related molecular mechanisms research
- Chronic Lymphocytic Leukemia Research
- Enzyme Production and Characterization
- Hepatitis C virus research
- Cancer Research and Treatments
- Glycosylation and Glycoproteins Research
- Hepatitis B Virus Studies
- RNA Research and Splicing
National Taiwan University Hospital
2016-2025
Huazhong University of Science and Technology
2023-2025
University of Washington
1996-2025
Tongji University
2015-2025
Shanghai Tongji Urban Planning and Design Institute
2025
Shanghai Jiao Tong University
2019-2025
Anhui University
2025
Ningbo Medical Center Lihuili Hospital
2025
Ruijin Hospital
1999-2025
Penn State Milton S. Hershey Medical Center
2025
Crystal structures of bovine heart cytochrome c oxidase in the fully oxidized, reduced, azide-bound, and carbon monoxide–bound states were determined at 2.30, 2.35, 2.9, 2.8 angstrom resolution, respectively. An aspartate residue apart from O 2 reduction site exchanges its effective accessibility to matrix aqueous phase for one cytosolic concomitantly with a significant decrease pK carboxyl group, on metal sites. The movement indicates as proton pumping site. A tyrosine acidified by...
A superparamagnetic iron oxide (SPIO) nanoparticle is emerging as an ideal probe for noninvasive cell tracking. However, its low intracellular labeling efficiency has limited the potential usage and evoked great interest in developing new strategies. We have developed fluorescein isothiocyanate (FITC)-incorporated silica-coated core−shell SPIO nanoparticles, SPIO@SiO2(FITC), with diameters of 50 nm, a bifunctionally magnetic vector that can efficiently label human mesenchymal stem cells...
Current sources of stem cells include embryonic (ESCs) and adult (ASCs). However, concerns exist with either source: ESCs, their significant ethical considerations, tumorigenicity, paucity cell lines; ASCs, which are possibly more limited in potential. Thus, the search continues for an ethically conducive, easily accessible, high‐yielding source cells. We have isolated a population multipotent from human term placenta, temporary organ fetal contributions that is discarded postpartum. These...
Mitochondrial cytochrome c oxidase plays an essential role in aerobic cellular respiration, reducing dioxygen to water a process coupled with the pumping of protons across mitochondrial inner membrane. An aspartate residue, Asp-51, located near enzyme surface, undergoes redox-coupled x-ray structural change, which is suggestive for this residue redox-driven proton pumping. However, functional or mechanistic evidence involvement has not yet been obtained. We report that Asp-51 → Asn mutation...
Fatal hepatitis B virus (HBV) reactivation in lymphoma patients with "resolved" HBV infection (hepatitis surface antigen [HBsAg] negative and core antibody [anti-HBc] positive) can occur, but the true incidence severity remain unclear. From June 2009 to December 2011, 150 newly diagnosed resolved who were receive rituximab-CHOP (cyclophosphamide, doxorubicin, vincristine, prednisolone)-based chemotherapy prospectively followed. DNA was checked at baseline, start of each cycle chemotherapy,...
Background and purpose The identification of reliable diagnostic prognostic biomarkers for Parkinson's disease (PD) is urgently needed. Here, we explored the potential use α‐synuclein (α‐syn) in plasma neuronal exosomes as a biomarker early PD diagnosis progression. Methods This study included both cross‐sectional longitudinal designs. subjects 36 patients with early‐stage PD, 17 advanced 20 idiopathic rapid eye movement sleep behavior disorder 21 healthy controls (HCs). α‐syn levels were...
Abstract Purpose: The transcription factor CCAAT/enhancer binding protein α, encoded by the CEBPA, is crucial for differentiation of immature granulocytes. Mutation CEBPA may play an important role in leukemogenesis and prognosis. We sought to characterize mutation acute myeloid leukemia (AML) clarify if there a distinct immunophenotype leukemic cells with mutation. Experiment Design: One hundred four patients de novo AML were evaluated cells. Results: Twenty-two mutations identified 16...
The progress of using gadolinium (Gd)-based nanoparticles in cellular tracking lags behind that superparamagnetic iron oxide (SPIO) magnetic resonance imaging (MRI). Here, dual functional Gd-fluorescein isothiocyanate mesoporous silica (Gd-Dye@MSN) possess green fluorescence and paramagnetism are developed order to evaluate their potential as effective T1-enhancing trackers for human mesenchymal stem cells (hMSCs). hMSCs labeled efficiently with Gd-Dye@MSN via endocytosis. Labeled unaffected...
Abstract BACKGROUND Sinonasal natural killer (NK)/T‐cell or T‐cell lymphoma behaves quite differently from other lymphomas. The objective of this study was to investigate clinical features, treatment outcomes, and failure patterns in patients with type sinonasal lymphoma. METHODS From September, 1977 December, 2000, 77 NK/T‐cell who had received radiotherapy (R/T), chemotherapy (C/T), both (R/T C/T) were evaluated retrospectively. RESULTS Fifty‐six (73%) locoregional disease only, 21 (27%)...
Abstract Nucleophosmin (NPM) mutations have been found in a significant proportion of adults with de novo acute myeloid leukemia (AML), especially those normal karyotype. These results provide basis for studies the pathogenesis this specific subgroup AML. In study, NPM were analyzed 173 Chinese patients AML, including and children. We that present 19.1% overall population 40.3% Adults had significantly higher incidence than children [32 126 (25.4%) versus 1 47 (2.1%), P < 0.001]....
Abstract The TP53 mutation is frequently detected in acute myeloid leukemia (AML) patients with complex karyotype (CK), but the stability of this during clinical course remains unclear. In study, mutations were identified 7% 500 de novo AML and 58.8% CK. closely associated older age, lower white blood cell (WBC) platelet counts, FAB M6 subtype, unfavorable-risk cytogenetics CK, negatively NPM1 mutation, FLT3/ ITD DNMT3A mutation. Multivariate analysis demonstrated that was an independent...
Inadvertent intraoperative hypothermia (core temperature <36°C) is a frequently preventable complication with several adverse consequences. Our study aimed to determine the overall incidence of inadvertent and its risk factors associated clinical outcomes in this national survey China.We conducted cross-sectional 30 days postoperative follow-up from November 2014 through August 2015. A total 3132 eligible patients underwent general anesthesia were randomly selected 28 hospitals nationwide...