A5078054883- Neuroblastoma Research and Treatments
- Acute Lymphoblastic Leukemia research
- Hemoglobinopathies and Related Disorders
- Acute Myeloid Leukemia Research
- Hematopoietic Stem Cell Transplantation
- Glycosylation and Glycoproteins Research
- Childhood Cancer Survivors' Quality of Life
- Iron Metabolism and Disorders
- Blood groups and transfusion
- Chronic Myeloid Leukemia Treatments
- Viral-associated cancers and disorders
- Cancer, Hypoxia, and Metabolism
- Lymphoma Diagnosis and Treatment
- Toxin Mechanisms and Immunotoxins
- Hepatitis B Virus Studies
- Neutropenia and Cancer Infections
- Autoimmune and Inflammatory Disorders Research
- Neonatal Health and Biochemistry
- Polyomavirus and related diseases
- Parvovirus B19 Infection Studies
- Platelet Disorders and Treatments
- Immunodeficiency and Autoimmune Disorders
- Ubiquitin and proteasome pathways
- Pharmacological Effects and Toxicity Studies
- Cell Adhesion Molecules Research
National Taiwan University Hospital
2016-2025
Shanghai Children's Hospital
2019-2025
Shanghai Jiao Tong University
2019-2025
Xiamen University
2024
Wenzhou Medical University
2024
Chang Gung University
2000-2024
East China Normal University
2024
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2024
National Taiwan University
2007-2023
National Natural Science Foundation of China
2019
Background Following a clinical evaluation of deferasirox (Exjade) it was concluded that, in addition to baseline body iron burden, ongoing transfusional intake should be considered when selecting doses. The 1-year EPIC study, the largest ever investigation conducted for an chelator, is first evaluate whether fixed starting doses deferasirox, based on intake, with dose titration guided by serum ferritin trends and safety markers, provides clinically acceptable chelation patients (aged >or=2...
Abstract Nucleophosmin (NPM) mutations have been found in a significant proportion of adults with de novo acute myeloid leukemia (AML), especially those normal karyotype. These results provide basis for studies the pathogenesis this specific subgroup AML. In study, NPM were analyzed 173 Chinese patients AML, including and children. We that present 19.1% overall population 40.3% Adults had significantly higher incidence than children [32 126 (25.4%) versus 1 47 (2.1%), P < 0.001]....
We have assessed the impact of α-synuclein overexpression on differentiation potential and phenotypic signatures two neural-committed induced pluripotent stem cell lines derived from a Parkinson's disease patient with triplication human SNCA genomic locus. In parallel, comparative studies were performed control healthy individuals generated iPS-derived neuroprogenitor infected lentivirus incorporating small hairpin RNA to knock down mRNA. The exhibited reduced capacity differentiate into...
This study measured the potentiation effects of plyometric training [normalized electromyography (EMG) in triceps surae, stiffness and elastic energy utilization Achilles tendon] investigated correlations between these performances [voluntary electromechanical delay (EMD) jump height]. Twenty‐one subjects were randomly assigned either to control group (10 subjects: age 22.3±1.6 years) or a (11 22.1±1.6 that performed 8 weeks training. Results: As compared with before training, normalized EMG...
Summary. The Epstein‐Barr virus (EBV), or human herpesvirus‐6 (HHV‐6) associated haemophagocytic lymphohistiocytosis, has been found prevalent in Taiwan; it affects previously healthy children and is always fatal when treated only supportively. Recognition of the underlying pathogenesis for this disease prompted adoption an immunomodulatory regimen intravenous immunoglobulin (IVIG) and/or etoposide on 17 such patients between 1990 1993. Remarkable improvement patients’ prognoses was...
Neuroblastic tumors are childhood neoplasms that possess amino acid decarboxylase (AADC) activity and can theoretically be imaged by <sup>18</sup>F-fluorodihydroxyphenylalanine (<sup>18</sup>F-FDOPA) PET, a new diagnostic tool for neuroendocrine tumors. In this study, we explored the accuracy clinical role of <sup>18</sup>F-FDOPA PET in neuroblastic <b>Methods:</b> From 2008 to 2011, patients with tissue-proven receiving at initial diagnosis or during follow-ups were enrolled. The...
Despite current risk‐directed therapy, approximately 15–20% of pediatric patients with acute lymphoblastic leukemia (ALL) have relapses. Recent genome‐wide analyses identified that an alteration IKZF1 is associated very poor outcomes in B‐cell progenitor ALL. In this study, we determined the prognostic significance deletions childhood This study analyzed 242 ALL Taiwan. We developed a simple yet sensitive multiplex quantitative PCR coupled capillary electrophoresis to accurately determine...
Abstract Graft-versus-host disease (GVHD) is a major concern for patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT). Ruxolitinib has been proven effective in treating adult steroid-refractory GVHD; however, studies on pediatric are relatively scarce. Thus, this single-center study evaluated the efficacy and safety of ruxolitinib with GVHD. We retrospectively reviewed data aged < 18 years who underwent HSCT received treatment either acute GVHD (aGVHD) or chronic...
This study aimed to assess the utility of magnetically controlled capsule endoscopy (MCE) in diagnosis pediatric gastrointestinal diseases. A retrospective cohort was conducted, which collected data from 1040 children (546 males and 494 females; mean age: 11.0 ± 2.6 years) who underwent MCE at Shanghai Children's Hospital between June 2017 February 2023. Information on gastric visualization, cleanliness, examination times, lesion detection rates, other parameters were recorded. 2-week...
OBJECTIVE—To study the prevalence of and risk factors for abnormal glucose tolerance in transfusion-dependent β-thalassemic patients. RESEARCH DESIGN AND METHODS—A total 89 patients were interviewed. Diabetes was previously diagnosed 14 them. In remaining 75 patients, 68 participated an oral test. Potential identified using independent t test, χ2 Fisher’s exact Logistic regression analysis used to select that best predicted tolerance. A two-tailed P value &lt;0.05 considered be...
Ten cases of pediatric fulminant hemophagocytic syndrome, encountered between 1986 and 1989, are described. They occurred in the summer, patients presented with fever, jaundice, hepatosplenomegaly, pancytopenia, coagulopathy, abnormal liver function. Bone marrow studies revealed infiltration by atypical T-lymphoid cells, rare B immunoblasts, mature histiocytes hemophagocytosis. Initially, histiocytic medullary reticulosis was suspected six cases. The clinical course characterized rapid...
Two childhood cases are reported of peripheral T-cell lymphoma; the neoplastic cells expressed activated CD8 (T8) phenotype and contained Epstein-Barr viral (EBV) DNA. Both patients had an aggressive rapid clinical course despite chemotherapy. Elevated titers antibodies to EBV-viral capsid antigen (>640) early (>10) were found in both patients. Histology revealed pleomorphic immunoblastic lymphoma with extensive necrosis one case angioimmunoblastic lymphadenopathy-like pattern containing...
The incidence and clinical spectrum of severe bacterial infection were studied in 89 patients with thalassemia major that was diagnosed between January 1971 March 2002. There 20 24 episodes infection, resulting an 1.6 infections per 100 patient-years. included liver abscess (6 cases), septicemia soft-tissue (2 osteomyelitis corneal ulcer (1 case), enteritis abscesses the lung, kidney, intra-abdominal region, retropharynx, gums, buttocks case each). leading causal microorganisms gram-negative...
The presence of Plasmodium ovale has never been previously reported in Myanmar. Using blood samples obtained many villages across the country between 1996 and 2000, molecular diagnosis species was made with semi- or full-nested polymerase chain reaction (PCR) species-specific primers, followed by agarose gel electrophoresis to detect amplification products. P. also confirmed another PCR-based diagnosis, microtiterplate hybridization (MPH) method using probes. Both methods target A type small...