A5029808858- Alzheimer's disease research and treatments
- Protein Structure and Dynamics
- Proteins in Food Systems
- Healthcare during COVID-19 Pandemic
- Glycosylation and Glycoproteins Research
- Enzyme Production and Characterization
- Thyroid Cancer Diagnosis and Treatment
- Phytase and its Applications
- Monoclonal and Polyclonal Antibodies Research
- Public Health in Brazil
- Thyroid Disorders and Treatments
- Diabetes Treatment and Management
- Diabetes and associated disorders
- Diabetes Management and Research
- Microencapsulation and Drying Processes
- Advanced Biosensing Techniques and Applications
- Enzyme Structure and Function
- Ubiquitin and proteasome pathways
- Nuclear Receptors and Signaling
- Adrenal Hormones and Disorders
- Neuroscience and Neuropharmacology Research
- Cell Adhesion Molecules Research
- Collagen: Extraction and Characterization
- Cholinesterase and Neurodegenerative Diseases
- Nanofabrication and Lithography Techniques
Universidade Federal do Rio de Janeiro
2000-2020
Institute of Biomedical Science
2016-2017
Max Planck Institute for Biophysical Chemistry
2008-2015
Max Planck Society
2011
Universidade Federal do Estado do Rio de Janeiro
2008
We have assessed the impact of α-synuclein overexpression on differentiation potential and phenotypic signatures two neural-committed induced pluripotent stem cell lines derived from a Parkinson's disease patient with triplication human SNCA genomic locus. In parallel, comparative studies were performed control healthy individuals generated iPS-derived neuroprogenitor infected lentivirus incorporating small hairpin RNA to knock down mRNA. The exhibited reduced capacity differentiate into...
The amyloid precursor protein (APP) is implied both in cell growth and differentiation neurodegenerative processes Alzheimer disease. Regulated proteolysis of APP generates biologically active fragments such as the neuroprotective secreted ectodomain sAPPalpha neurotoxic beta-amyloid peptide. Furthermore, it has been suggested that intact transmembrane plays a signaling role, which might be important for normal synaptic plasticity neuronal dysfunction dementia. To understand signaling, we...
The Hexosamine Biosynthetic Pathway (HBP) is a branch of glycolysis responsible for the production key substrate protein glycosylation, UDP-GlcNAc. Cancer cells present altered glucose metabolism and aberrant pointing to alterations on HBP. Recently it was demonstrated that HBP influences many aspects tumor biology, including development metastasis. In this work we characterize in melanoma analyze its importance cellular processes related metastatic phenotype. We demonstrate an increase...
The crystal structures of β‐lactoglobulin genetic variants A and B have been determined in the orthorhombic space group C222 1 (lattice Y) by X‐ray diffraction at 2.0 Å 1.95 resolution, respectively. structural comparison shows that both exhibit open conformation EF loop pH crystallization (pH 7.9), contrast to what has reported for same 7.1 trigonal P3 2 21 Z) [Qin, B.Y., Bewley, M.C., Creamer, L.K., Baker, E.N. & Jameson, G.B. (1999) Protein Sci. 8 , 75–83]. Furthermore, it was found...
Beta-lactoglobulin, the main whey protein in bovine milk, exists several isoforms of which most abundant are A and B. We have previously reported denaturation beta-lactoglobulin by hydrostatic pressure [Valente-Mesquita, V.L., Botelho, M.M. & Ferreira, S.T. (1998) Biophys. J. 75, 471-476]. Here, we compare stabilities These differ two amino-acid substitutions: Asp64 Val118 isoform replaced glycine alanine, respectively, Replacement buried residue smaller alanine side-chain is not accompanied...
The β-amyloid peptide (Aβ), the major component of senile plaques found in brains Alzheimer's disease patients, is derived from proteolytic processing a transmembrane glycoprotein known as amyloid precursor protein (APP). Human APP exists various isoforms, which ones contain 695, 751, and 770 amino acids. Proteolytic cleavage by α- or β-secretases releases extracellular soluble fragments sAPPα sAPPβ, respectively. Despite fact that plays important roles both physiological pathological...
Hemangiomas are benign tumors, which cause an abnormal proliferation of endothelial cells. In recent years, propranolol (POP) has been used for the therapy infantile hemangiomas (IH). Topical POP prescribed instead systemic steroids to reduce risk side effects. order increase effectiveness POP, nanoemulsions (NEs) were developed as drug delivery carriers topical delivery. NEs stable dispersions consisting oil, water and surfactants. To develop water‐in‐oil, was solubilized in two...
Background: The aim of the study was to determine rate satisfactory glycemic control among patients with type 2 diabetes (T2D) followed up at a tertiary referral hospital in Brazil. Methods: A retrospective and observational conducted between September 2014 2015, by collecting data from medical records. Results: Data were obtained 1,001 patients. majority women (68%), median age 61 years old (21 - 95). duration disease 10 (1 58). Satisfactory found 51% strongest factors related good were:...
Background: The aim of the study was to determine rate satisfactory glycemic control among patients with type 2 diabetes (T2D) followed up at a tertiary referral hospital in Brazil. Methods: A retrospective and observational conducted between September 2014 2015, by collecting data from medical records. Results: Data were obtained 1,001 patients. majority women (68%), median age 61 years old (21 - 95). duration disease 10 (1 58). Satisfactory found 51% strongest factors related good were:...
Background: Hypothyroidism control is inadequate in up to 30-40% of patients. This study aimed determine the rate primary hypothyroidism and demographic clinical factors associated with control. Methods: An observational retrospective was conducted between January 2014 October 2015. Data were obtained from 174 medical records. Regarding analysis, patients subdivided into two groups: appropriate group inappropriate group. Autoimmune post-surgical secondary benign nodular thyroid disease...
Background: The incidence of type 1 diabetes (T1D) has been increasing worldwide, leading to a serious public health problem resulting in reduced life expectancy and increased morbidity. aim this study was determine the glycemic control rate its demographic clinical factors, T1D followed up at tertiary referral hospital Brazil. Methods: An observational retrospective conducted between October 2014 2015. Data were obtained from 140 medical records. Results: Satisfactory found 22.14% patients....
Background: Hypothyroidism control is inadequate in up to 30-40% of patients. This study aimed determine the rate primary hypothyroidism and demographic clinical factors associated with control. Methods: An observational retrospective was conducted between January 2014 October 2015. Data were obtained from 174 medical records. Regarding analysis, patients subdivided into two groups: appropriate group inappropriate group. Autoimmune post-surgical secondary benign nodular thyroid disease...
Background: The incidence of type 1 diabetes (T1D) has been increasing worldwide, leading to a serious public health problem resulting in reduced life expectancy and increased morbidity. aim this study was determine the glycemic control rate its demographic clinical factors, T1D followed up at tertiary referral hospital Brazil. Methods: An observational retrospective conducted between October 2014 2015. Data were obtained from 140 medical records. Results: Satisfactory found 22.14% patients....
A 24-year-old Caucasian female patient was referred to our endocrinology service investigate a structural magnetic resonance imaging (sMRI) finding of "pituitary mass". The first two sMRI were identified as pituitary adenoma but the following examinations suggested possibility hyperplasia (PH). for diagnostic clarification and therapy due divergence in reports surgical procedure indicated by neurosurgical team other institution. had no complaints, laboratory tests all normal, clearly showed...