A5081155708- Birth, Development, and Health
- Acute Lymphoblastic Leukemia research
- Childhood Cancer Survivors' Quality of Life
- Pregnancy and preeclampsia studies
- Neonatal Respiratory Health Research
- Adipose Tissue and Metabolism
- Liver Disease Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Neuroblastoma Research and Treatments
- Diet and metabolism studies
- Liver Disease and Transplantation
- Fatty Acid Research and Health
- Iron Metabolism and Disorders
- Infant Nutrition and Health
- Nitric Oxide and Endothelin Effects
- Gestational Diabetes Research and Management
- Hemoglobinopathies and Related Disorders
- Kawasaki Disease and Coronary Complications
- Neonatal Health and Biochemistry
- Circadian rhythm and melatonin
- Biochemical effects in animals
- Diet, Metabolism, and Disease
- Cardiovascular Disease and Adiposity
- Reproductive System and Pregnancy
Kaohsiung Chang Gung Memorial Hospital
2016-2025
Chang Gung University
2016-2025
Chiayi Chang Gung Memorial Hospital
2019-2025
Chang Gung Memorial Hospital
2011-2022
Weatherford College
2022
Primus Consulting (United States)
2022
ORCID
2021
National Chiayi University
2021
Chang Gung Children's Hospital
2007-2017
National Chi Nan University
2016
Obesity and related disorders have increased concurrently with an consumption of saturated fatty acids. We examined whether post-weaning high fat (HF) diet would exacerbate offspring vulnerability to maternal HF-induced programmed hypertension kidney disease sex-specifically, a focus on the kidney. Next, we aimed elucidate gene–diet interactions that contribute renal programming using next generation RNA sequencing (NGS) technology. Female Sprague-Dawley rats received either normal (ND) or...
Compromised pregnancies such as those associated with gestational diabetes mellitus, intrauterine growth retardation, preeclampsia, maternal undernutrition, and stress may negatively affect fetal development. Such induce oxidative to the fetus alter development through epigenetic process that at a later stage. Melatonin is an oxidant scavenger reverses during prenatal period. Moreover, role of melatonin in modifications field developmental programming has been studied extensively. Here, we...
Glucocorticoids are administered to premature infants accelerate pulmonary maturation. In experimental model, prenatal dexamethasone (DEX) results in reduced nephron number and adulthood hypertension. Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase (NOS), can cause oxidative stress is involved the development L-citrulline be converted l-arginine (the substrate for NOS) body. Thus we intended determine if maternal therapy prevent DEX-induced programmed...
Nonalcoholic fatty liver disease (NAFLD) can develop in prenatal stages and be exacerbated by exposure to a postnatal high-fat (HF) diet. We investigated the protective effects of resveratrol on HF diet-induced NAFLD.Male Sprague-Dawley rat offspring were placed five experimental groups (n = 10-12 per group): normal diet (VNF), maternal (ONF), (VHF), diet/postnatal (OHF). A therapeutic group with for (OHFR) was used comparison. Resveratrol (50 mg/kg/day) dissolved drinking water from...
Despite current risk‐directed therapy, approximately 15–20% of pediatric patients with acute lymphoblastic leukemia (ALL) have relapses. Recent genome‐wide analyses identified that an alteration IKZF1 is associated very poor outcomes in B‐cell progenitor ALL. In this study, we determined the prognostic significance deletions childhood This study analyzed 242 ALL Taiwan. We developed a simple yet sensitive multiplex quantitative PCR coupled capillary electrophoresis to accurately determine...
Abstract Aims. To report a study examining the relationships among coping, anxiety and resilience to identify predictors of in adolescents undergoing cancer treatment. Background. Anxiety is main psychological disturbance with cancer, but context related treatments have not been investigated. Design. Cross‐sectional study. Methods. Adolescents ( n = 131) recruited from three medical centres between 2010–2011. The eligible participants were diagnosed without mental disease receiving...
This study aimed to the impact of a combination maternal and post-weaning high-fat diets whether resveratrol was beneficial. Sprague-Dawley dams were fed either chow or diet, before mating, during pregnancy, into lactation. At weaning, their offspring randomly diet. Four experimental groups generated: CC (maternal/postnatal diet), HC (maternal high-fat/postnatal CH chow/postnatal HH diet). A fifth group consisted plus resveratrol. The 4 month-old had higher body weight, levels plasma...
Methotrexate (MTX) is a commonly used chemotherapy drug, yet its late neurotoxic side effects are gaining attention. The aim of the study was to evaluate role miR-155 in pathogenesis MTX-induced cognitive impairment, mainly focused on interplay blood-brain barrier (BBB) integrity and MTX toxicity. We use young rat model mimicking children leukemia treatment protocol, focusing systemic effect central nervous system by intraperitoneal (IP) injection. function evaluated Morris Water Maze test...
Unconventional genetic subtypes of B-cell precursor acute lymphoblastic leukaemia (B-ALL) were analysed to compare their frequency and impact on outcomes between children young adults in Taiwan. found 23.0% 456 paediatric B-ALL 24.5% 139 adult B-ALL. The most frequently unconventional subtype both was BCR::ABL1-like, which could be subdivided into different kinase-altering aberrations 67.3% 78.6% adults. CRLF2-R more frequent children, while IL7R mutations common In favourable observed...
Baicalein is the flavonoids with multiple pharmacological activities. The aim of our study was to investigate effects baicalein on colorectal cancer (CRC) and recognize targets treatment. To better understand baicalein's target, proteomic approaches were used purify identify protein substrates using 2D difference gel electrophoresis (2D SDS‐PAGE) elucidate proteins differential display. Results from this that treatment CRC cells results in reduced cell proliferation. As a result, displays...
Prenatal dexamethasone (DEX) exposure and high-fat (HF) intake are linked to hypertension. We examined whether maternal melatonin therapy prevents programmed hypertension synergistically induced by prenatal DEX plus postnatal HF in adult offspring. also causes renal programming using next-generation RNA sequencing (NGS) technology. Pregnant Sprague-Dawley rats received intraperitoneal (0.1 mg/kg) or vehicle from gestational day 16 22. In the melatonin-treatment groups (M), 0.01% drinking...
Kawasaki disease (KD) is the leading cause of acquired heart during childhood in developed countries. The mechanism and biomarkers KD remain to be determined. In this study, we sought elucidate potential plasma proteomic markers patients comparison that febrile controls. Plasma samples from controls were subjected two-dimensional polyacrylamide gel electrophoresis analysis. Differential protein displays between Fibrinogen beta gamma chains, alpha-1-antitrypsin (A1AT), CD5 antigen-like...
Kawasaki disease (KD) is a type of systemic vasculitis that primarily affects children under the age five years old. For sufferers KD, intravenous immunoglobulin (IVIG) has been found to successfully diminish occurrence coronary artery lesions. Anemia commonly in KD patients, and we have shown appropriately elevated hepcidin levels are related decreased hemoglobin these patients. In this study, investigated time period anemia iron metabolism during different stages KD. A total 100 patients...
Hypertension can originate from early-life exposure to oxidative stress. As reported, dimethyl fumarate (DMF) activates nuclear factor erythroid-derived 2-related 2 (Nrf2) and protects against stress damage. We examined whether maternal DMF therapy adult offspring hypertension programmed by prenatal dexamethasone (DEX) postnatal high-fat (HF) diet exposure. male Sprague Dawley rat at 4 months of age five groups (n = 11-13/group): control, DEX (0.1mg/kg i.p. gestational day 16 22), HF (D12331...
Abstract Background Fat accumulation in the liver contributes to development of non-alcoholic fatty disease (NAFLD). N-acetylcysteine (NAC) is an antioxidant, acting both directly and indirectly via upregulation cellular antioxidants. We examined mechanisms steatosis after 12 months high fat (HF) diet tested ability NAC rescue steatosis. Methods Seven-week-old C57BL/6 (B6) male mice were administered HF for (HF group). Two other groups received accompanied by (HFD + NAC(1–12)) or 6...
Background: Maternal obesity in utero may affect fetal development and cause metabolic problems during childhood even adulthood. Diet-induced maternal can impair gut barrier integrity change the microbiome, which contribute to adverse placental adaptations increase risk offspring. However, mechanism through causes offspring disorder must be identified. Methods: Eight-week-old female rats received a control diet or high-fat (HF) for 11 weeks before conception gestation. The placentas were...