A5065020070- Venous Thromboembolism Diagnosis and Management
- Diagnosis and Treatment of Venous Diseases
- Central Venous Catheters and Hemodialysis
- Acute Lymphoblastic Leukemia research
- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Childhood Cancer Survivors' Quality of Life
- Chronic Lymphocytic Leukemia Research
- Cancer Cells and Metastasis
- Erythrocyte Function and Pathophysiology
- Hemoglobinopathies and Related Disorders
- Cell death mechanisms and regulation
- Phagocytosis and Immune Regulation
- Immune cells in cancer
- Retinoids in leukemia and cellular processes
- Blood groups and transfusion
- Iron Metabolism and Disorders
- Glioma Diagnosis and Treatment
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Parvovirus B19 Infection Studies
- Odor and Emission Control Technologies
- Neutropenia and Cancer Infections
- Mast cells and histamine
- Radiation Dose and Imaging
- Bioactive natural compounds
Changhua Christian Hospital
2015-2025
Chiayi Chang Gung Memorial Hospital
2019-2024
Chang Gung University
2019-2023
Taipei Medical University
2023
Taipei Medical University Hospital
2023
Boston Children's Hospital
2013
Chang Hua Hospital
2005
Wan Fang Hospital
2003
Bechtel (United States)
1982
Children are more susceptible to radiation-induced damage than adults, but little research has compared the risk of cancer after exposure radiation during computed tomography (CT) among children at different ages. We aimed explore intracranial tumours, leukemia or lymphoma children, adolescents and young adults (aged < 25 yr) from CT before age 18 years.We conducted a nested, population-based case-control study using data Taiwan's publicly funded health care system. identified participants...
Unconventional genetic subtypes of B-cell precursor acute lymphoblastic leukaemia (B-ALL) were analysed to compare their frequency and impact on outcomes between children young adults in Taiwan. found 23.0% 456 paediatric B-ALL 24.5% 139 adult B-ALL. The most frequently unconventional subtype both was BCR::ABL1-like, which could be subdivided into different kinase-altering aberrations 67.3% 78.6% adults. CRLF2-R more frequent children, while IL7R mutations common In favourable observed...
Abstract Background To explore the diagnostic performance of triggered angiography non-contrast-enhanced magnetic resonance imaging (TRANCE-MRI) for evaluation venous pathology lower extremity. Methods This was a single-centre prospective cohort study 25 patients with suspected disease in extremities. Each patient received Doppler ultrasonography (for evaluation) before scheduled TRANCE-MRI and arterial evaluations) on 1.5 T MR scanner (Philips Ingenia, Philips Healthcare, Best,...
Objective To determine the prevalence and risk factors of hypogonadotropic hypogonadism in transfusion-dependent patients with thalassemia. Patients Methods The authors examined 29 thalassemia major aged 15 years or older. Luteinizing hormone-releasing hormone tests were performed β-thalassemia mutations analyzed by direct sequencing. Results was 72%. Failure puberty observed 5 11 (45%) boys 7 18 (39%) girls. Arrested noted two (18%) five girls (28%). Ten (56%) did not menstruate, (11%) had...
Background In Taiwan, the prevalence of β-thalassemia trait is at least 1.1%. The Taiwan government initiated a National Screening Program in 1993. Herein we examine differences before and after initiation this program. Procedure Data consisting total number patients birth major were collected. Ninety-one with transfusion-dependent thalassemia treated our hospitals included for analysis. DNA analysis was performed 86 patients. Results 361 exist. per 100,000 births 5.6% 1994 declined to 1.21...
A 19-month-old boy with chronic granulomatous disease (CGD) received umbilical cord blood transplantation (UCBT) from an unrelated donor after experiencing a life-threatening disseminated Bacillus Calmette-Guérin infection. After busulfan and cyclophosphamide conditioning, we performed 5/6-matched UCBT. Engraftment mixed chimerism was 100% in peripheral blood, of his neutrophils had normal oxidative burst activity on day 17. The patient is now 3 years old, free infection, growing well. To...
Although venous duplex ultrasonography (USG) is reliable for diagnosing lower extremity disease (LEVD), cross-sectional imaging studies were usually required before intervention or surgery. Patients of LEVD with renal insufficiency restrict the use contrast-enhanced modalities. In seeking an alternative solution these patients, we explore clinical utility triggered angiography non-contrast-enhanced magnetic resonance (TRANCE-MRI) in assessment LEVD.We collected data from patients presenting...
Background Deep vein thrombosis is a severe health problem. Treatment options may differ between acute and chronic deep thrombosis. Thus, distinguishing from essential for patients with Triggered angiography non-contrast enhanced an innovative magnetic resonance imaging protocol that provide objective evidence in differentiating Method We prospectively collected information on consecutive who had been evaluated through triggered venous pathology their lower extremities at vascular wound care...
The myeloid sarcoma is an extramedullary finding of acute leukemia (AML), and orbital leukemic tumors occur most commonly during the first decade life. To our knowledge, we report youngest patient with bilateral proptosis both eyes as initial manifestation AML. This case highlights need for peripheral blood smear neuro-image work-up in infancy. AML should be considered differential diagnosis mass, even absence typical symptoms.
Two quantitative PCR (qPCR)-based methods, for clonal immunoglobulin or T-cell receptor gene (Ig/TCR) rearrangements and fusion transcripts, are widely used the measurement of minimal residual disease (MRD) in patients with B-precursor acute lymphoblastic leukemia (ALL). MRD bone marrow samples from 165 carrying three major including 74 BCR-ABL1, 54 ETV6-RUNX1, 37 TCF3-PBX1, was analyzed by using two qPCR-based methods. The correlation coefficient both methods good TCF3-PBX1 (R2 = 0.8088)...
The prenatal course of a rare case with fetal anemia caused by maternal anti-c alloimmunization was reported.A 39-year-old female and anti-E antibodies against red cells had previously experienced stillbirth. At her present pregnancy, titers middle cerebral artery peak systolic velocity (MCA-PSV) were frequently monitored to investigate the severity hemolytic anemia. Rather than manifesting as an increase in MCA-PSV, anemic fetus delivered at 32 weeks one day gestation sole presentation:...
e23521 Background: Pharmacologic treatment for soft tissue sarcoma (STS) remains challenging. There is a lack to predict responses chemotherapy or targeted therapy oncologic drivers. We hypothesize that circulating tumor cells may enrich cancer initiating and represent window probe personalized drug response. In this study, we test if sensitivity profile of short-term culture organoids derived from (CTCs) correlates clinical Methods: From April 2019 December 2020, 50 patients with...
Lower extremity venous disease (LEVD) is a complex disorder, and determining the etiology of LEVD paramount for treatment selection. Two-dimensional phase-contrast magnetic resonance imaging (2D PC-MRI) can provide an objective measure hemodynamic status may help differentiate between different etiologies LEVD. A total 271 participants, including 256 symptomatic patients with lower 15 healthy volunteers, were collected in this cohort study.It single-center prospective observational study...
Background: To examine the application of quantitative 2-dimensional phase-contrast MRI (2D PC-MRI) for treating patients with pelvic congestion syndrome (PCS). Materials and Methods: The authors conducted a retrospective cross-sectional analysis by using 2D PC-MRI data enrolled between April 2017 September 2023. In addition, 32 healthy female controls (HCs) were included. Results: Most PCS presented chronic pain more than half had extrapelvic venous symptoms (80/81, 98% 45/81, 56%,...
Mitochondria, vital organelles that generate ATP, determine cell fate. Dysfunctional and damaged mitochondria are fragmented removed through mitophagy, a mitochondrial quality control mechanism. The FDA-approved drug IMQ, synthetic agonist of Toll-like receptor 7, exhibits antitumor activity against various skin malignancies. We previously reported IMQ promptly reduced the level antiapoptotic Mcl-1 protein overexpression attenuated IMQ-triggered apoptosis in cancer cells. Furthermore,...