A5065572900- Neuroblastoma Research and Treatments
- Glycosylation and Glycoproteins Research
- Toxin Mechanisms and Immunotoxins
- Acute Lymphoblastic Leukemia research
- Childhood Cancer Survivors' Quality of Life
- Cancer, Hypoxia, and Metabolism
- Cell Adhesion Molecules Research
- Glioma Diagnosis and Treatment
- Hemophilia Treatment and Research
- Blood groups and transfusion
- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Ubiquitin and proteasome pathways
- Erythrocyte Function and Pathophysiology
- Chromatin Remodeling and Cancer
- Glaucoma and retinal disorders
- Acute Myeloid Leukemia Research
- Vascular Malformations and Hemangiomas
- Pituitary Gland Disorders and Treatments
- Hemoglobinopathies and Related Disorders
- Hedgehog Signaling Pathway Studies
- Retinal and Macular Surgery
- Neurogenesis and neuroplasticity mechanisms
- Intraocular Surgery and Lenses
- Vascular Tumors and Angiosarcomas
Taipei Medical University Hospital
2021-2025
Taipei Medical University
2021-2024
Fu Jen Catholic University
2011-2022
St. Jude Children's Research Hospital
2021
National Taiwan University Hospital
2003-2016
National Taiwan University
2013-2014
Institute of Cellular and Organismic Biology, Academia Sinica
2013
Kaohsiung Veterans General Hospital
2008-2013
Memorial Hospital
2013
Shin Kong WHS Memorial Hospital
2012
Infant-type hemispheric glioma (IHG) is a rare pediatric brain tumor with variable response to chemotherapy and radiotherapy. Molecular insights into IHG can be useful in identifying potentially active targeted therapy. A male fetus was found have congenital hydrocephalus at the gestational age of 37 weeks. Fetal MRI showed 2.6 × 2.0-cm located frontal horn left lateral ventricle, involving basal nuclei thalamus. Tumor biopsy 2 days revealed an consisting spindle cells strong expression GFAP...
Delayed childbearing is a growing trend globally, with Taiwan experiencing one of the steepest increases in maternal age. Advanced age affects offspring health, including birth outcomes and long-term morbidity. However, its impact remains underexplored. This study investigates these effects using nationwide cohort. retrospective cohort utilized data from Taiwan's National Health Insurance Research Database (NHIRD), covering infants born January 1, 2004, to December 31, 2014. The included...
Abstract Germline expression of rearranged TCR alpha-chain transgenes with the Ig H chain enhancer reproducibly elicits T cell-mediated autoimmune disease in thyroid gland, gastric mucosa, Langerhans islets, salivary ovaries, and testes selected strains normal mice. Multiple organs are destroyed a single transgenic mouse same organ different MHC background, suggesting transgene can elicit self-reactive cell clones having Ag specificities restrictions. Construction this autoimmune-inducing...
Aberrant expression of the simple mucin-type carbohydrate antigens such as T, Tn, sialyl-T and sialyl-Tn is associated with poor prognosis in several cancers. β1,3-N-acetylglucosaminyltransferase-3 (B3GNT3), a member β3GlcNAcT family, responsible for forming extended core 1 (T antigen) oligosaccharides. The role B3GNT3, which expressed various tissues including human fetal brain, regulating neuroblastoma (NB) formation cell behaviors remains unclear. Here, we showed that increased B3GNT3...
Abstract Purpose: Neuroblastoma (NB) is a neural crest-derived tumor that commonly occurs in childhood. β-1,4-Galactosyltransferase III (B4GALT3) highly expressed human fetal brain and responsible for the generation of poly-N-acetyllactosamine, which plays critical role progression. We therefore investigated expression B4GALT3 NB. Experimental Design: examined specimens from 101 NB patients by immunohistochemistry analyzed correlation between clinicopathologic factors or survival. The...
// Wan-Ling Ho 1,4,6,7,* , Chih-Hsing Chou 5,* Yung-Ming Jeng 2 Meng-Yao Lu 1 Yung-Li Yang Shiann-Tarng Jou Dong-Tsamn Lin Hsiu-Hao Chang Kai-Hsin Wen-Ming Hsu 3,8 and Min-Chuan Huang 5,8 Department of Pediatrics, National Taiwan University Hospital College Medicine, Taipei, Pathology, 3 Surgery, 4 Graduate Institute Clinical 5 Anatomy Cell Biology, 6 Shin Kong Wu Ho-Su Memorial Hospital, 7 School Fu Jen Catholic University, New Taipei City, 8 Research Center for Developmental Biology...
We demonstrate for the first time a continuous and almost linear work function adjustment between 3.93 4.93eV using Hf/sub x/Mo/sub (1-x)/ binary alloys deposited by co-sputtering. In view of process integration, dual metal gate technology Mo formed intermixing was proposed. Work values were verified to be thickness ratio accurate can possible. Furthermore, one allowed get around thermal stability issue choosing an appropriate total corresponding budget subsequent deposition, since required...
Abstract Background Advances in treatment have improved the prognosis β‐thalassemia major. We present survival and complications pattern of those patients northern Taiwan born after 1970. Procedure One‐hundred sixty with major 1970 were collected. The Kaplan–Meier method log‐rank test used to estimate compare survival. Cox regression models examine associations bone marrow transplantation (BMT), time BMT procedure, Results Better was observed for 1980 ( P = 0.0121). Heart disease,...
Background Discontinuation of E. coli l ‐asparaginase in patients with acute lymphoblastic leukemia (ALL) is unavoidable upon severe allergic reaction. We sought to examine outcomes following discontinuation due reactions. Procedure evaluated the outcome children enrolled Taiwan Pediatric Oncology Group‐2002‐ALL protocol between 2002 and 2012, who had discontinued reactions, compared those continued Erwinia (Erwinase) did not. Results Among 700 this study, 33 treatment Five‐year overall...
Background Reinduction therapy has improved the outcomes in children with acute lymphoblastic leukemia (ALL). We sought to determine optimal course(s) of reinduction for standard-risk (SR, or "low-risk" other groups) patients. Also, we evaluated using triple intrathecal without cranial radiation (CrRT) central nervous system (CNS) preventive therapy. Procedure From 2002 2012, all newly diagnosed ALL Taiwan were enrolled Pediatric Oncology Group ALL-2002 protocol. SR patients randomized...
Background Childhood cancer survivors are at a high risk of medical consequences their disease and treatment. There is growing information about the long-term health issues childhood survivors; however, there very few studies describing care utilization costs for this unique population. Understanding services will provide basis developing strategies to better serve these individuals potentially reduce cost. Objective This study aims determine in Taiwan. Methods nationwide, population-based,...
We investigated and evaluated the demographics, clinical laboratory features, treatment responses, disease duration of 25 children with immune thrombocytopenia (ITP) eligible for detection antiplatelet antibodies. found that patients without antecedent preceding infection (API) were more likely to have anti-GPIa/IIa than those API (42.9% vs. 5.5%, P=0.048). Age groups <2 years 2 10 show response (R) or complete (CR) given treatments, whereas none whose onset age >10 showed R CR treatments...
Abstract Background In childhood acute lymphoblastic leukemia (ALL), t(1;19)(q23;p13.3) with TCF3‐PBX1 fusion is one of the most frequent translocations. Historically, it has been associated poor prognosis. Intensive treatment, however, improved its outcome. We determined outcome children this genotype treated contemporary intensive chemotherapy in Taiwan. Procedure Taiwan Pediatric Oncology Group 2002 ALL studies, genotypes were by cytogenetic analysis and/or reverse transcriptase...
Abstract Objective To evaluate the muscle thickness and walking test in people with haemophilia A (PWH) their correlation to joint health functional impairments. Design Cross-sectional study Results 29 severe/moderate PWH were enrolled. Muscle of quadriceps medial gastrocnemius measured using ultrasound. Joint capacity assessed Haemophilia Health Score (HJHS), Early Arthropathy Detection Ultrasound (HEAD-US), 6-Minute Walking (6MWT), Quality Life Questionnaire for Adults (Haem-A-QoL),...
Abstract Atypical teratoid/rhabdoid tumors (ATRTs) are highly aggressive pediatric brain with sensitivity to proteasome inhibitors in preclinical models. We evaluated the feasibility of combining inhibitor bortezomib chemotherapy. Patients aged 0-20 years newly diagnosed ATRT were enrolled from January 2022 through December 2023. A modified Medical University Vienna (MUV)-ATRT regimen was used. They treated 1.3 mg/m2/dose given intravenously or subcutaneously twice a week for 2 weeks...
The neocortex, the center for higher brain function, emerged in mammals and expanded course of evolution. expansion outer radial glia (oRGs) intermediate progenitor cells (IPCs) plays key roles consequential folding neocortex. Therefore, understanding mechanisms oRG IPC is important neocortical development By using mice human cerebral organoids, we previously revealed that hedgehog (HH) signaling expands oRGs IPCs. Nevertheless, it remained to be determined whether HH IPCs vivo gyrencephalic...
Abstract Improvement in outcomes of children with acute myeloid leukemia (AML) is attributed to several refinements clinical management. We evaluated treatment Taiwanese pediatric AML patients the past 20 years. Overall, 860 de novo aged 0–18 years and registered Childhood Cancer Foundation R.O.C during January 1996–December 2019 were included. Survival analysis was performed identify factors that improved outcomes. Regardless modalities used, 2008–2019 had better 5-year event-free survival...
Abstract The neocortex, the center for higher brain function, emerged in mammals and expanded course of evolution. expansion outer radial glia (oRGs) intermediate progenitor cells (IPCs) plays key roles consequential folding neocortex. Therefore, understanding mechanisms oRG IPC is important neocortical development By using mice human cerebral organoids, we previously revealed that hedgehog (HH) signaling expands oRGs IPCs. Nevertheless, it remained to be determined whether HH IPCs vivo...