A5041190240- Psoriasis: Treatment and Pathogenesis
- Dermatology and Skin Diseases
- Hepatitis B Virus Studies
- Pharmaceutical studies and practices
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Colorectal Cancer Screening and Detection
- Hormonal Regulation and Hypertension
- AI in cancer detection
- Adrenal Hormones and Disorders
- Viral Infections and Immunology Research
- Renal Diseases and Glomerulopathies
- Autoimmune Bullous Skin Diseases
- Hepatitis C virus research
- Sepsis Diagnosis and Treatment
- Breast Lesions and Carcinomas
- Breast Cancer Treatment Studies
- Ultrasound Imaging and Elastography
- Health Systems, Economic Evaluations, Quality of Life
- Marine and fisheries research
- Immunodeficiency and Autoimmune Disorders
- Heart Rate Variability and Autonomic Control
- Anesthesia and Pain Management
- Ubiquitin and proteasome pathways
- Anesthesia and Sedative Agents
- Immune Response and Inflammation
Guangdong Pharmaceutical University
2025
Guizhou University
2025
Yangzhou University
2024-2025
Jilin Province Tumor Hospital
2024-2025
National Taiwan University Hospital
2014-2024
National Taiwan University
2002-2024
Janssen (United States)
2021-2024
Johnson & Johnson (United States)
2021-2024
Soochow University
2011-2024
First Affiliated Hospital of Soochow University
2011-2024
Recombinant adenoviruses are an attractive vehicle for gene therapy to the lung in treatment of cystic fibrosis (CF). First-generation viruses deleted E1a and E1b transduce genes into airway epithelial cells vivo; however, expression transgene is transient associated with substantial inflammatory responses, transfer significantly reduced following a second administration virus. In this study, we have used mice deficient immunological effector functions combination adoptive passive techniques...
Little is known about the annual changes in cancer incidence and survival that occurred after establishment of long-form registry database Taiwan. Therefore, this study aimed to investigate updated stage-specific relative rates (RSRs) among adult patients Taiwan.Cancer data from 2002 2012 were collected using Taiwan Cancer Registry Database. Age-standardized rates, average percent (AAPCs), sex ratios calculated for adults. Five-year RSRs estimated cases diagnosed between 2004 2008 followed...
The kidney has tremendous capacity to repair after acute injury, however, pathways guiding adaptive and fibrotic are poorly understood. We developed a model of regeneration by titrating ischemic injury dose. performed detailed biochemical histological analysis profiled transcriptomic changes at bulk single-cell level (> 110,000 cells) over time. Our highlights proximal tubule cells as key susceptible injury. Adaptive correlated with fatty acid oxidation oxidative phosphorylation. identify...
Interleukin (IL)-23, an IL-12 cytokine family member, is a hierarchically dominant regulatory in cluster of immune-mediated inflammatory diseases (IMIDs), including psoriasis, psoriatic arthritis, and bowel disease. We review IL-23 biology, signaling IMIDs, the effect inhibition treating these diseases. propose studies to advance biology unravel differences response anti–IL-23 therapy. Experimental evidence generated from investigations could establish novel molecular ontology centered...
Both rheumatoid arthritis and animal models of autoimmune are characterized by hyperactivation synovial cells hyperplasia the membrane. The activated produce inflammatory cytokines degradative enzymes that lead to destruction cartilage bones. Effective treatment may require elimination most or all cells. death factor Fas/Apo-1 its ligand (FasL) play pivotal roles in maintaining self-tolerance immune privilege. Fas is expressed constitutively tissues, dramatically upregulated at site...
Psoriasis is a chronic disease requiring long-term therapy.Physician- and patient-reported outcomes were evaluated through week 252 in VOYAGE 1 2.In total, 1829 patients randomized at baseline to receive guselkumab 100 mg every 8 weeks, placebo or adalimumab. Patients receiving crossed over 16. adalimumab 52 1, withdrawal retreatment occurred weeks 28-76 2; all then received open-label 252. Efficacy health-related quality of life (HRQoL) endpoints analysed Safety was monitored 264.The...
Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition that causes substantial physical, emotional and psychological burdens. Guselkumab, monoclonal antibody binds to the p19 subunit of interleukin-23, has demonstrated high levels efficacy in treatment diseases, including psoriasis psoriatic arthritis.To evaluate effect guselkumab on HS, phase 2, multicentre, randomized, placebo-controlled, double-blind, proof-of-concept study was conducted.Patients ≥18 years age with...
To evaluate the potential differences in plankton diversity and stability within freshwater lake reservoir ecosystems, this study employed eDNA metabarcoding to analyze diversity, assembly mechanisms, stability, environmental drivers of communities natural water (Y region) artificial (M at Liupanshui Minghu National Wetland Park, Guizhou Province, China. The revealed notable regional variations mechanisms. Specifically, Shannon, Simpson, Pielou's evenness indices were higher M region,...
Abstract Introduction Sepsis is the leading cause of acute kidney injury (AKI) in critical patients. The optimal timing initiating renal replacement therapy (RRT) septic AKI patients remains controversial. objective this study to determine impact early or late initiation RRT, as defined using simplified RIFLE (risk, injury, failure, loss function, and end-stage failure) classification (sRIFLE), on hospital mortality among Methods Patient with sepsis requiring RRT surgical intensive care...
<h3>Background</h3> Systemic inflammation and dysregulated immune function in chronic obstructive pulmonary disease (COPD) is hypothesized to predispose patients development of herpes zoster. However, the risk zoster among with COPD undocumented. We therefore aimed investigate COPD. <h3>Methods</h3> conducted a cohort study using data from Taiwan Longitudinal Health Insurance Database. performed Cox regressions compare hazard ratio (HR) an age- sex-matched comparison cohort. divided into...
Automated whole breast ultrasound (ABUS) is becoming a popular screening modality for examination. Compared to conventional handheld ultrasound, ABUS achieves operator-independent and feasible mass screening. However, reviewing hundreds of slices in an image volume time-consuming. A computer-aided detection (CADe) system based on watershed transform was proposed this study accelerate the reviewing. The applied gather similar tissues around local minima be homogeneous regions. likelihoods...
Background and Purpose— Although previous research reveals that cardiovascular events thromboembolic diseases are important causes of death in patients with bullous pemphigoid (BP), the risk stroke after diagnosis BP relative to general population remains unknown. Using a randomly selected nationwide population-based sample, this study investigates compared unaffected individuals similar age. Methods— This analyzes data from Taiwan's National Health Insurance Research Database. sample...
Porcine hemagglutinating encephalomyelitis virus (PHEV) is a highly neurovirulent coronavirus that invades the central nervous system (CNS) in piglets. Although important progress has been made toward understanding biology of PHEV, many aspects its life cycle remain obscure. Here we dissected molecular mechanism underlying cellular entry and intracellular trafficking PHEV mouse neuroblastoma (Neuro-2a) cells. We first performed thin-section transmission electron microscopy (TEM) assay to...