A5025120257- Clinical Nutrition and Gastroenterology
- Gastric Cancer Management and Outcomes
- Diet and metabolism studies
- Nutrition and Health in Aging
- Enhanced Recovery After Surgery
- Gastrointestinal Tumor Research and Treatment
- Gastrointestinal disorders and treatments
- Electrolyte and hormonal disorders
- Bariatric Surgery and Outcomes
- Immune Response and Inflammation
- Connective Tissue Growth Factor Research
- Helicobacter pylori-related gastroenterology studies
- Metastasis and carcinoma case studies
- Cancer, Hypoxia, and Metabolism
- Esophageal and GI Pathology
- Cardiac, Anesthesia and Surgical Outcomes
- Intensive Care Unit Cognitive Disorders
- Cytokine Signaling Pathways and Interactions
- Angiogenesis and VEGF in Cancer
- Protease and Inhibitor Mechanisms
- Respiratory Support and Mechanisms
- Appendicitis Diagnosis and Management
- Sepsis Diagnosis and Treatment
- MicroRNA in disease regulation
- Immune Cell Function and Interaction
National Taiwan University Hospital
2015-2024
Fujian Medical University
2013-2024
Fujian Provincial Hospital
2009-2024
Capital Medical University
2024
Nanjing University of Chinese Medicine
2024
Affiliated Hospital of Youjiang Medical University for Nationalities
2024
Second Affiliated Hospital of Fujian Medical University
2024
Alcon (United States)
2024
Xihua University
2022
Guangdong Provincial Hospital of Traditional Chinese Medicine
2021-2022
<h3>Importance</h3> Older patients undergoing abdominal surgery commonly experience preventable delirium, which extends their hospital length of stay (LOS). <h3>Objective</h3> To examine whether a modified Hospital Elder Life Program (mHELP) reduces incident delirium and LOS in older surgery. <h3>Design, Setting, Participants</h3> This cluster randomized clinical trial 577 eligible enrolled 377 (≥65 years age) gastrectomy, pancreaticoduodenectomy, colectomy at 2000-bed urban medical center...
The association of cytokine genotypes with gastric carcinoma (GC) may be influenced by environmental factors and varies among different populations. Few studies have addressed the impact on development progression GC. We analyzed 11 functional polymorphisms in tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1, IL-4 IL-10 genes 220 Taiwanese Chinese GC 230 healthy controls. risk was adjusted confounding risks. Our results revealed that frequency Helicobacter pylori infection [odds...
Resveratrol, a polyphenolic compound found in grapes and other fruits, has been reported to inhibit angiogenesis with an as yet elusive mechanism. Here, we investigate the detailed mechanism by which resveratrol inhibits vascular endothelial growth factor (VEGF)-induced angiogenic effects human umbilical cells (HUVECs). Exposure of HUVECs 1 2.5 μM significantly blocked VEGF-mediated migration tube formation but not cell proliferation. Under same concentrations, failed affect VEGF-stimulated...
The aggressiveness of a tumor is partly attributed to its resistance chemotherapeutic agent-induced apoptosis. Cysteine-rich 61 (Cyr61), from the CCN gene family, secreted and matrix-associated protein, which involved in many cellular activities such as growth differentiation. Here we established cell model system examine whether stable expression Cyr61 MCF-7 cells can confer apoptosis identify possible participating mechanisms. We showed that lines overexpressing had acquired remarkable...
Hypoxia-inducible factor-1alpha (HIF-1alpha) is widely considered to be one of the key regulators tumor angiogenesis. The upstream regulation complex and involves several growth factors, cytokines, hypoxia. Herein, we have identified miR-519c as a hypoxia-independent regulator HIF-1alpha, acting through direct binding HIF-1alpha 3' untranslated region leading reduced Overexpression resulted in significant decrease protein levels tube formation human umbilical vein endothelial cells;...
Abstract Background Transumbilical single-incision laparoscopic cholecystectomy (SILC) and minilaparoscopic (MLC) are both increasingly being used to treat symptomatic gallstones. The present study compared SILC MLC with respect outcome in a prospective randomized trial. Methods Seventy patients cholelithiasis were or (35 each group). primary measure was postoperative pain. Secondary outcomes duration of operation, complications, analgesic requirements, length hospital stay, cosmetic result,...
MicroRNAs (miRNAs) influence many biological processes, including cancer. They do so by posttranscriptionally repressing target mRNAs to which they have sequence complementarity. Although it has been postulated that miRNAs can regulate other miRNAs, this never shown experimentally our knowledge. Here, we demonstrate miR-107 negatively regulates the tumor suppressor miRNA let-7 via a direct interaction. was found be highly expressed in malignant tissue from patients with advanced breast...
Right hepatectomy for a living liver donor via pure minimally invasive approach is challenging procedure and only few cases have been reported. Between May 2013 August 2015, 13 patients underwent robotic right in our institute, 54 received open surgery. In this series, no conversion was conducted hepatectomy. The 2 groups shared similar blood loss (169 versus 146 mL), complication rates (7.7% 9.3%), recovery of function (peak alanine aminotransferase, 269 252 IU/mL). group needed longer...
Cyclooxygenase 2 (COX-2) has been reported to be commonly expressed in advanced stages of human lung adenocarcinoma. In this study, the COX-2 constitutive expression vector was transfected into a adenocarcinoma cell line CL1.0 and several clones were obtained which stably COX-2. These COX-2-overexpressed demonstrated remarkable resistance apoptosis induced by Ultraviolet B (UVB) irradiation, vinblastine (VBL) lymphoma-2 (Bcl-2), or other anti-cancer drugs. To understand how prevents...
Two strictly anaerobic bacterial strains (YUAN-3 T and X-29) were isolated from activated sludge of molasses wastewater in a continuous stirred-tank reactor. The Gram-positive, non-spore-forming, mesophilic motile. Cells regular rods (0·4–0·8×1·5–8·0 μm) occurred singly, pairs sometimes chains up to eight. Autoaggregative autofluorescent growth strain YUAN-3 non-aggregative X-29 observed at 20–44 °C pH 3·5–9·0. Both hydrolysed gelatin aesculin fermented several kinds mono-, di-...
Vascular endothelial growth factor C (VEGF-C) is a critical activator of tumor lymphangiogenesis that recently has been strongly implicated in the metastasis process. In this study, we identified HRG-β1 stimulated up-regulation VEGF-C mRNA and protein human breast cancer cells dosage- time-dependent manner was de novo RNA synthesis-dependent. The HRG-β1-induced increase expression effectively reduced by treatment with Herceptin, an antibody specifically against HER2. Also, when HER2...
Perforin-deficient [perforin (-/-)] mice were infected with two strains of JHM virus (JHMV) to analyze the role perforin-mediated cytotoxicity in acute lethal and subacute central nervous system (CNS) infections. During both infections, overall mortality perforin (-/-) was not different from that controls. Perforin survived longer than controls, consistent reduced morbidity. Both cleared as controls; however, rate clearance delayed mice, indicating cytolysis is involved viral clearance. The...
Interleukin-6 (IL-6) is a multifunctional cytokine that associated with the disease status and outcomes of gastric cancer. Nonetheless, underlying mechanism how IL-6 promotes spread cancer still unclear. In this study, we used modified Boyden chamber assay to test invasion ability different cell lines. Liposome-mediated transfection was introduce an expression vector into AGS cells, transfectants were further examined for active RhoA phosphorylated Src using pull-down...
The acs1 knockout mutant that has a disruption in the plastidic acetyl-coenzyme A (CoA) synthetase (ACS; At5g36880) gene was used to explore role of this protein and acetate metabolism Arabidopsis (Arabidopsis thaliana). Disruption ACS decreased activity by 90% largely blocked incorporation exogenous 14C-acetate 14C-ethanol into fatty acids. Whereas had no significant effect on synthesis bulk seed triacylglycerols, plants were smaller flowered later. This suggests pyruvate dehydrogenase...
Abstract BACKGROUND: Annexin A1 (AnxA1) has been well‐known as a glucocorticoid‐regulated anti‐inflammatory protein, and it is implicated in tumorigenesis tumor type–specific pattern. However, the role of AnxA1 gastric cancer (GC) indeterminate, underlying mechanism not clear. The purpose this study was to evaluate prognostic significance associated GC. METHODS: Immunohistochemical staining employed analyze 118 GC patients. Both gain‐of‐function loss‐of‐function approaches were performed...
To investigate whether genetic differences in cytokine promoter polymorphisms effect various outcomes after exposure to Epstein-Barr virus (EBV) infection, 30 patients with EBV-positive gastric carcinoma (GC), 120 EBV-negative GC, and 220 control subjects were enrolled. Promoter of tumor necrosis factor (TNF)-alpha at positions -238 -308 interleukin (IL)-10 position -1082 determined. The frequency the high-producer allele (-308A) TNF-alpha gene was significantly higher among GC compared...
Pyogenic granuloma is a benign inflammatory lesion demonstrating obvious activity of angiogenesis. Female steroid hormones are believed to play important roles in the etiology because frequently found females with high levels sex hormones. Few molecular mechanisms pathogenesis have been proposed and proven. The purpose this study was detect compare expression angiogenesis-associated factors among healthy gingiva, gingiva from periodontitis, pyogenic clarify granuloma.Fifteen specimens were...