A5085610498- Pancreatitis Pathology and Treatment
- Pancreatic and Hepatic Oncology Research
- Gastrointestinal disorders and treatments
- Helicobacter pylori-related gastroenterology studies
- IgG4-Related and Inflammatory Diseases
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Asymmetric Synthesis and Catalysis
- Neuroendocrine Tumor Research Advances
- Gastric Cancer Management and Outcomes
- Advanced biosensing and bioanalysis techniques
- Cancer Genomics and Diagnostics
- Chemical Synthesis and Reactions
- Pneumonia and Respiratory Infections
- Menstrual Health and Disorders
- Extracellular vesicles in disease
- Viral-associated cancers and disorders
- Catalytic Cross-Coupling Reactions
- Catalytic Alkyne Reactions
- Antibiotics Pharmacokinetics and Efficacy
- Pediatric Hepatobiliary Diseases and Treatments
- Liver Disease Diagnosis and Treatment
- Gastroesophageal reflux and treatments
- Chemical Reactions and Isotopes
- Synthetic Organic Chemistry Methods
- Medical Imaging Techniques and Applications
China Institute of Sport Science
2025
Danbury Hospital
2025
Chung Yuan Christian University
2025
National Taiwan University Hospital
2014-2024
National Taiwan University
2013-2024
State Key Laboratory of Food Science and Technology
2023-2024
Jiangnan University
2023-2024
Shanghai Micro Satellite Engineering Center
2024
Jiangsu Cancer Hospital
2024
Nanjing Medical University
2019-2024
ABSTRACT The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions extracellular vesicles (EVs), collective term covering various subtypes cell‐released, membranous structures, called exosomes, microvesicles, microparticles, ectosomes, oncosomes, apoptotic bodies, many other names. However, specific issues arise when working with these entities, whose size amount often make them difficult to obtain as relatively...
To study the prevalence of atopic dermatitis, allergic rhinitis, and asthma in Taiwan, we analysed claims data a nationally representative cohort 997,729 enrolees from National Health Insurance register 2000 to 2007. Overall, 66,446 patients were diagnosed with 49.8% them had concomitant rhinitis and/or asthma. The overall 8-year prevalences 6.7%, 26.3% 11.9%, respectively. Children adolescents significantly higher these diseases. dermatitis females was lower than that males before age 8...
Autoimmune pancreatitis (AIP) is a distinct disease entity of chronic pancreatitis. Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) key negative regulator the T-cell immune response, and its gene highly polymorphic. Many positive associations between cytotoxic T-lymphocyte-associated protein (CTLA4) single-nucleotide polymorphisms various autoimmune diseases have been identified. We investigated possible genetic CTLA4 in Chinese population with AIP.We performed genotyping for (49 A/G,...
Abstract BACKGROUND Characterization of circulating tumor cells (CTCs) has been used to provide prognostic, predictive, and pharmacodynamic information in many different cancers. However, the clinical significance CTCs microemboli (CTM) patients with pancreatic ductal adenocarcinoma (PDAC) yet be determined. METHODS In this prospective study, CTM were enumerated peripheral blood 63 PDAC before treatment using anti-EpCAM (epithelial cell adhesion molecule)–conjugated supported lipid...
Epstein–Barr Virus (EBV) DNase (BGLF5) is an alkaline nuclease and has been suggested to be important in the viral life cycle. However, its effect on host cells remains unknown. Serological histopathological studies implied that EBV seems correlated with carcinogenesis. Therefore, we investigate of epithelial cells. Here, report expression induces increased formation micronucleus, indicator genomic instability, human We also demonstrate, using γH2AX comet assay, DNA damage. Furthermore, cell...
Circulating tumor cells (CTCs) released from a periampullary or pancreatic cancer can be more frequently detected in the portal than systemic circulation and potentially used to identify patients with liver micrometastases. Aims of this study is determine if CTCs count venous blood nonmetastatic adenocarcinoma as predictor for subsequent metastases. were quantified peripheral samples collected simultaneously during pancreaticoduodenectomy presumed without image-discernible metastasis....
Abstract How does the brain enable us to remember two or more object representations in visual working memory (VWM) without confusing them? This “gluing” process, feature binding, refers ability join certain features together while keeping them segregated from others. Recent neuroimaging research has reported higher BOLD response left temporal and parietal cortex during a binding-VWM task. However, less is known about how regions work synchrony support such process. In this study, we applied...
To investigate whether genetic differences in cytokine promoter polymorphisms effect various outcomes after exposure to Epstein-Barr virus (EBV) infection, 30 patients with EBV-positive gastric carcinoma (GC), 120 EBV-negative GC, and 220 control subjects were enrolled. Promoter of tumor necrosis factor (TNF)-alpha at positions -238 -308 interleukin (IL)-10 position -1082 determined. The frequency the high-producer allele (-308A) TNF-alpha gene was significantly higher among GC compared...
Abstract Nasopharyngeal carcinoma (NPC) is an endemic malignancy prevalent in South East Asia. Epidemiological studies have associated this disease closely with Epstein‐Barr virus (EBV) infection. Previous also showed that EBV reactivation implicated the progression of NPC. Thus, we proposed recurrent reactivations may be important for its pathogenic role. In study, NPC cell lines latently infected EBV, NA and HA, corresponding EBV‐negative lines, NPC‐TW01 (TW01) HONE‐1, were treated 12‐ O...
A triple round: palladium-catalyzed cyclotrimerization of 1,2-diarylacetylenes has been developed to synthesize highly substituted 8,8a-dihydrocyclopenta[a]indenes. One such cycloadduct (1) displays unusual aggregation-induced emission with a strong blue fluorescence (see picture). The structures the products have confirmed by X-ray crystal analysis.
Tumor cells with diverse phenotypes and biological behaviors are influenced by stromal through secretory factors or direct cell-cell contact. Pancreatic ductal adenocarcinoma (PDAC) is characterized extensive desmoplasia fibroblasts as the major cell type. In present study, we observe enrichment of myofibroblasts in a juxta-tumoral position tumor undergoing epithelial-mesenchymal transition (EMT) that facilitates invasion correlates worse clinical prognosis PDAC patients. Direct contacts...