A5101436167- Pancreatitis Pathology and Treatment
- Pancreatic function and diabetes
- Pluripotent Stem Cells Research
- Cellular transport and secretion
- Appendicitis Diagnosis and Management
- Pancreatic and Hepatic Oncology Research
- Neuroscience and Neuropharmacology Research
- Veterinary Pharmacology and Anesthesia
- Folate and B Vitamins Research
- Protease and Inhibitor Mechanisms
- Assisted Reproductive Technology and Twin Pregnancy
- Galectins and Cancer Biology
- Axon Guidance and Neuronal Signaling
- Phagocytosis and Immune Regulation
- Pediatric Hepatobiliary Diseases and Treatments
- Healthcare cost, quality, practices
- Ion channel regulation and function
- Prenatal Screening and Diagnostics
- Cardiac electrophysiology and arrhythmias
- Veterinary Medicine and Surgery
- Prenatal Substance Exposure Effects
- Craniofacial Disorders and Treatments
- Diet, Metabolism, and Disease
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Diet and metabolism studies
Roslin Institute
2022
University of Edinburgh
2022
University of Liverpool
1985-2019
Royal Liverpool and Broadgreen University Hospital NHS Trust
2019
Royal Liverpool University Hospital
2019
NIHR Liverpool Pancreatic Biomedical Research Unit
2018
Giant trypsin-containing endocytic vacuoles are formed in pancreatic acinar cells stimulated with inducers of acute pancreatitis. F-actin envelops and regulates their properties. Endocytic can rupture release content into the cytosol cells. fuse plasma membrane exocytose content.Intrapancreatic activation trypsinogen is an early event hallmark development vacuoles, which form by disconnection transport large post-exocytic structures, only resolvable sites trypsin activity live In present...
Activation of trypsinogen (formation trypsin) inside the pancreas is an early pathological event in development acute pancreatitis. In our previous studies we identified activation within endocytic vacuoles (EVs), cellular organelles that appear pancreatic acinar cells treated with inducers EVs are formed as a result aberrant compound exocytosis and subsequent internalization post-exocytic structures. These can be up to 12 μm diameter actinated (i.e. coated F-actin). Notably, undergo...
Abstract Diabetic women are more likely to give birth infants with congenital malformations than nondiabetic women. Rodent embryos have been used as a model for the study of abnormal fetal development associated maternal diabetes, and some metabolic factors which altered in such raised glucose ketones, shown cause rodent vitro. The present work explores further teratogenicity β‐hydroxybutyrate rat embryos. To determine sensitivities at different stages their development, 9.5 days gestation...
The acquisition of systemic blood pressure (SBP) provides valuable information regarding cardiovascular function and tissue perfusion in human veterinary species.To evaluate the agreement between Parks Medical Doppler (PMD) Mano Médical Vet BP (MMVBP) for assessing SBP conscious dogs.40 client-owned dogs were prospectively enrolled; measurements acquired by a single operator using PMD then MMVBP. mean five consecutive each device was classified according to target organ damage (TOD) risk...