A5049080612- Pancreatitis Pathology and Treatment
- Gastrointestinal disorders and treatments
- Pancreatic and Hepatic Oncology Research
- Liver Disease Diagnosis and Treatment
- Diverticular Disease and Complications
- Gallbladder and Bile Duct Disorders
- Inflammatory Bowel Disease
- Gastrointestinal Tumor Research and Treatment
- Hippo pathway signaling and YAP/TAZ
- Cellular Mechanics and Interactions
- Liver Disease and Transplantation
- Microscopic Colitis
- Education Pedagogy and Practices
- Alcohol Consumption and Health Effects
- Gastrointestinal Bleeding Diagnosis and Treatment
- Colorectal Cancer Screening and Detection
- Education and Digital Technologies
- Viral-associated cancers and disorders
- Esophageal and GI Pathology
- Helicobacter pylori-related gastroenterology studies
- Neuroendocrine Tumor Research Advances
- Hepatitis C virus research
- Liver Diseases and Immunity
- Eosinophilic Esophagitis
- Retinal and Optic Conditions
Centro De Medicina Veterinária Anjos De Assis
2023
Centro Hospitalar Lisboa Norte
2015-2021
Polytechnic Institute of Castelo Branco
2021
Administração Regional de Saúde de Lisboa e Vale do Tejo
2021
Hospital de Santa Maria
2015-2020
University of Lisbon
2016-2019
Mother Teresa Hospital
2019
Bogomolets National Medical University
2019
Queen Giovanna Hospital
2019
Korea Advanced Institute of Science and Technology
2019
Formation of blood vessel networks by sprouting angiogenesis is critical for tissue growth, homeostasis and regeneration. How endothelial cells arise in adequate numbers arrange suitably to shape functional vascular poorly understood. Here we show that YAP/TAZ promote stretch-induced proliferation rearrangements whilst preventing bleeding developing vessels. Mechanistically, increase the turnover VE-Cadherin formation junction associated intermediate lamellipodia, promoting both cell...
Morphogenesis of hierarchical vascular networks depends on the integration multiple biomechanical signals by endothelial cells, cells lining interior blood vessels. Expansion arises through sprouting angiogenesis, a process involving extensive cell rearrangements and collective migration. Yet, mechanisms controlling angiogenic behavior remain poorly understood. Here, we show this is regulated non-canonical Wnt signaling. We identify that Wnt5a specifically activates Cdc42 at junctions...
Background: Hepatitis C virus (HCV) is a unique which interacts with cholesterol, iron and insulin metabolism. There limited data on the effects of direct-acting antiviral agents (DAAs) metabolic profiles. We aimed at evaluating behavior risk factors chronically HCV-infected patients after sustained virologic response (SVR), comparing outcomes new DAAs versus old treatment regimen Peg-interferon ± ribavirin.Methods: A total 178 who achieved SVR completed one year follow-up were prospectively...
Acute pancreatitis (AP) is an aggressive and potentially fatal clinical condition. Although all age groups are at risk, the elderly may be a group of special concern. We aimed evaluating outcomes patients with elderly-onset AP.Using single-center retrospective database, treatment follow-up records 550 admitted AP were reviewed. Outcomes included mortality, admission to ICU, need for interventional procedures, nutritional support, length hospital ICU stay. Elderly-onset was defined as episode...
Abstract Background & Aims Chronic liver disease is a major worldwide cause of morbidity and mortality. Palliative care policies are not clearly established in chronic disease. The NECPAL CCOMS ‐ ICO © ( NEC esidades PAL iativas/Palliative Needs) tool to identify palliative needs, including section for Aim: aim this study was needs patients hospitalised tertiary referral Liver Unit. Methods Single‐centre prospective observational study. One hundred twenty with cirrhosis were included...
Acute pancreatitis (AP) represents a complex and potentially fatal disease with highly variable clinical course. Three classification systems for assessing the severity in AP have been validated use.The aim of present study was to evaluate performance Atlanta Determinant-based classifications predicting severe outcomes patients AP.In this retrospective we reviewed treatment follow-up records 525 admitted our unit between years 2003 2014. Outcomes included mortality, admission ICU, need...
ABSTRACT Formation of a hierarchically organized blood vessel network by sprouting angiogenesis is critical for tissue growth, homeostasis and regeneration. How in this process endothelial cells arise adequate numbers arrange suitably to shape functional vascular poorly understood. Here we show that YAP TAZ promote stretch-induced proliferation rearrangements whilst preventing bleeding developing vessels. Mechanistically, increase VE-cadherin turnover at junctions suppress Notch BMP...
Acute severe colitis (ASC) remains a challenging complication of ulcerative colitis. The early identification patients who will not respond to optimal therapy is warranted. Increasing evidence suggests that endoscopy may play role in predicting important outcomes acute colitis.The endoscopic activity consecutive with was evaluated using the Mayo sub-score (Mayo) and index severity (UCEIS). Two segmental indexes were also produced by summing scores rectum sigmoid (seg-Mayo seg-UCEIS,...
Este estudo examina as necessidades e perspectivas da formação continuada de professores no século XXI, considerando os desafios impostos pela era digital transformações cenário educacional. A pesquisa analisa políticas atuais docente Brasil, destacando lacunas existentes oportunidades inovação. Através uma revisão bibliográfica abrangente, o investiga tendências emergentes em continuada, incluindo a incorporação tecnologias digitais, metodologias ativas abordagens colaborativas. Os...
Primary effusion lymphoma (PEL) is one of the least common AIDS-related lymphomas, accounting for less than 1–4% cases. Clinical manifestations depend on extent and distribution disease and, as in majority patients no detectable mass lesion found, symptoms are related to fluid accumulation, dyspnoea (pleural or pericardial effusions), abdominal distension (ascites) joint swelling. The median survival after diagnosis, even with aggressive chemotherapy, remains poor remissions often short...
In this ESCHM 2016 conference talk report, we summarise two recently published original articles Franco et al. PLoS Biology 2015 and eLIFE 2016. The vascular network undergoes extensive vessel remodelling to become fully functional. Is it well established that blood flow is a main driver for remodelling. It has also been proposed pruning central process within physiological However, despite its function, the cellular molecular mechanisms regulating regression, their interaction with...
Chronic pancreatitis (CP) is a heterogeneous disease, with different causes and often long delay between onset full classic presentation. Clinical presentation depends on the stage of disease. In earlier stages, recurrent episodes acute are major signs dominating clinical As inflammatory process goes on, less occur, pain adopts aspects or may even disappear. After 10–15 years from onset, functional insufficiency occurs. Then, pancreatic exocrine endocrine appears. Diagnosis remains...
Signet ring cell carcinoma is a rare form of adenocarcinoma that predominantly affects the stomach. originated from ileum extremely and prognosis poor. We present case small bowel obstruction with features suggesting Crohn disease ileum. The symptoms were chronic diarrhea abdominal pain family history inflammatory disease. patient underwent surgery histopathology revealed both aspects signet An association between long-standing inflammation development this subtype tumor has been proposed...
Alcohol abuse can result in a spectrum of liver injury that ranges from mild fatty infiltration to alcoholic hepatitis (AH), cirrhosis, and hepatocellular carcinoma. The present study aimed evaluate current scoring systems predicting short-term long-term mortality because AH.Records 170 consecutive patients with AH admitted tertiary center between January 2005 October 2015 were reviewed. Clinical biochemical parameters retrieved for the assessment scores day admission (D1) seventh...
Abstract Background and study aims Colon interposition for benign strictures is associated with significant perioperative complications that carry high morbidity mortality. Although rarely reported in the literature, adenocarcinoma can occur as a late complication an interposed colonic segment. We report case of late-stage performed esophageal stricture.
Gastrointestinal tract involvement in immunodeficiency-related Burkitt's lymphoma is not common and the duodenal very rare.We report case of a 35-year-old man admitted because abdominal pain, vomiting weight loss.Human immunodeficiency virus infection was diagnosed upper digestive endoscopy showed marked edema hyperemia bulb with some violaceous areas.Immunohistochemical study bulbar tissue samples confirmed diagnosis lymphoma.To our knowledge, affecting only has been previously reported...
Chronic pancreatitis (CP) is a complex disease that should be treated by experienced teams of gastroenterologists, radiologists, surgeons, and nutritionists in multidisciplinary environment. Medical treatment includes lifestyle modification, nutrition, exocrine endocrine pancreatic insufficiency correction, pain management. Up to 60% patients will ultimately require some type endoscopic or surgical intervention for treatment. However, regardless the modality, they are often ineffective...
Strongyloidiasis is an infection caused by <i>Strongyloides stercoralis.</i> Gastrointestinal manifestations typically include duodenitis, chronic enterocolitis, and malabsorption, while gastric involvement very rare. In this case report, the authors present a of upper gastrointestinal bleeding ulcer with challenging etiological diagnosis. Portugal, there have been reports in past century autochthonous cases <i>S. stercoralis</i> suggesting endemic zones, but current...
Este estudo investigou a formação continuada de professores para práticas inclusivas, com o objetivo analisar como os programas contribuem implementação pedagógicas inclusivas nas escolas. A pesquisa teve uma abordagem qualitativa, baseada em revisão bibliográfica, utilizando fontes acadêmicas e documentos oficiais sobre tema. Foram analisados desafios enfrentados pelos durante processo formação, efetividade das políticas públicas contribuição da gestão escolar sucesso inclusão. Os...