A5013960872- Hippo pathway signaling and YAP/TAZ
- Cellular Mechanics and Interactions
- Immune cells in cancer
- Retinal Development and Disorders
- Cancer, Hypoxia, and Metabolism
- Chemokine receptors and signaling
- Angiogenesis and VEGF in Cancer
The Honourable Society of Lincoln's Inn
2012-2018
Cancer Research UK
2012-2018
Max Delbrück Center
2017-2018
Formation of blood vessel networks by sprouting angiogenesis is critical for tissue growth, homeostasis and regeneration. How endothelial cells arise in adequate numbers arrange suitably to shape functional vascular poorly understood. Here we show that YAP/TAZ promote stretch-induced proliferation rearrangements whilst preventing bleeding developing vessels. Mechanistically, increase the turnover VE-Cadherin formation junction associated intermediate lamellipodia, promoting both cell...
Angiogenesis requires coordinated changes in cell shape of endothelial cells (ECs), orchestrated by the actin cytoskeleton. The mechanisms that regulate this rearrangement vivo are poorly understood - largely because difficulty to visualize filamentous (F-actin) structures with sufficient resolution. Here, we use transgenic mice expressing Lifeact-EGFP F-actin ECs. We show retina, expression is restricted ECs allowing detailed visualization situ. labels associated cell-cell junctions, apical...
ABSTRACT Formation of a hierarchically organized blood vessel network by sprouting angiogenesis is critical for tissue growth, homeostasis and regeneration. How in this process endothelial cells arise adequate numbers arrange suitably to shape functional vascular poorly understood. Here we show that YAP TAZ promote stretch-induced proliferation rearrangements whilst preventing bleeding developing vessels. Mechanistically, increase VE-cadherin turnover at junctions suppress Notch BMP...