A5028862687- Hippo pathway signaling and YAP/TAZ
- Cellular Mechanics and Interactions
- Developmental Biology and Gene Regulation
- Angiogenesis and VEGF in Cancer
- Hedgehog Signaling Pathway Studies
- Advanced Breast Cancer Therapies
- Breast Cancer Treatment Studies
- Cancer Cells and Metastasis
- HER2/EGFR in Cancer Research
- Wnt/β-catenin signaling in development and cancer
- Cancer Genomics and Diagnostics
- Monoclonal and Polyclonal Antibodies Research
- Neurobiology and Insect Physiology Research
- Cancer Immunotherapy and Biomarkers
- Ferroptosis and cancer prognosis
- Cancer-related Molecular Pathways
- Lung Cancer Research Studies
- Chromosomal and Genetic Variations
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Cancer Research and Treatments
- Cancer Treatment and Pharmacology
Instituto de Biomedicina de Sevilla
2022-2024
Universidad de Sevilla
2023-2024
Consejo Superior de Investigaciones Científicas
2010-2024
Hospital Universitario Virgen del Rocío
2022-2024
Roche (Spain)
2023
University of Lisbon
2019-2022
Korea Advanced Institute of Science and Technology
2019
Google (United States)
2018
Junta de Andalucía
2012-2015
Centro Andaluz de Biología del Desarrollo
2015
Morphogenesis of hierarchical vascular networks depends on the integration multiple biomechanical signals by endothelial cells, cells lining interior blood vessels. Expansion arises through sprouting angiogenesis, a process involving extensive cell rearrangements and collective migration. Yet, mechanisms controlling angiogenic behavior remain poorly understood. Here, we show this is regulated non-canonical Wnt signaling. We identify that Wnt5a specifically activates Cdc42 at junctions...
By the end of 2020, there were more than 8 million women alive who had received a breast cancer diagnosis in previous 5 years, making it most prevalent neoplasia world. About 70% breast-cancer cases present positivity for estrogen and/or progesterone receptors and lack HER-2 overexpression. Endocrine therapy has traditionally been standard care ER-positive HER-2-negative metastatic cancer. In last advent CDK4/6 inhibitors shown that adding them to endocrine doubles PFS. As result, this...
The cancer stem cell (SC) theory proposes that a population of SCs serves as the driving force behind fundamental tumor processes, including metastasis, recurrence, and resistance to therapy. standard care for patients with stage III high-risk II colorectal (CRC) includes surgery adjuvant chemotherapy. Fluoropyrimidines their combination oxaliplatin increased cure rates, being able eradicate occult metastatic SC in fraction patients. treatment unresectable CRC is based on chemotherapy,...
Blood-vessel formation generates unique vascular patterns in each individual. The principles governing the apparent stochasticity of this process remain to be elucidated. Using mathematical methods, we find that transition between two fundamental morphogenetic programs—sprouting angiogenesis and remodeling—is established by a shift collective front-to-rear polarity endothelial cells mouse retina. We demonstrate competition biochemical (VEGFA) mechanical (blood-flow-induced shear stress) cues...
During development, extracellular signaling molecules interact with intracellular gene networks to control the specification, pattern and size of organs. One such molecule is Hedgehog (Hh). Hh known act as a morphogen, instructing different fates depending on distance its source. However, how Hh, when across cell field, impacts organ-specific transcriptional still poorly understood. Here, we investigate this issue during development Drosophila ocellar complex. The sensory structure, which...
The retinal determination gene network (RDGN) constitutes a paradigm of controlling organ specification and growth. In this study, we probed the RDGN in Drosophila ocelli, set simple eyes located on fly's dorsal head, by studying expression, regulation, function toy, hth, eya, so, members Pax6, Meis, Eya, Six families. Our results highlight role pax6 together with hh signaling pathway, initiation eya so expression; engagement feedback loop necessary for their full interplay between hth as...
In addition to the compound eyes, most insects possess a set of three dorsal ocelli that develop at vertices triangular cuticle patch, forming ocellar complex. The wingless and hedgehog signaling pathways, together with transcription factor encoded by orthodenticle, are known play major roles in specification patterning Specifically, is responsible for choice between ocellus fates within complex primordium. However, interaction signals factors date do not fully explain how this controlled....
In insects, the subdivision of head into a lateral region, harbouring compound eyes (CEs), and dorsal (medial) where ocelli localize, is conserved. This organization might have been already present in insects' euarthropodan ancestors. Drosophila, Wnt-1 homologue wingless (wg) plays major role genetic head. To analyse specifically wg signalling development head, we attenuated this pathway region by means. We find that loss transforms dorsal/medial structures, including ectopic CEs . Our...
e12651 Background: Achieving a pathological complete response (pCR) following neoadjuvant treatment (NAT) in HER2-positive tumors significantly enhances patient survival, resulting remarkable 92% reduction mortality risk. However, it is crucial to identify biomarkers capable of predicting the NAT response, moving towards more personalized medicine. This approach would enable identification patients likely respond specific therapies, thereby facilitating implementation targeted strategies....
Complete pathological response to neoadjuvant treatment (NAT) in breast cancer is associated with prolonged survival. Compared other immunophenotypes, luminal tumors are the least chemosensitive low rates of within this molecular subtype. Thus, finding predictors subset remains challenging. The emerging concept human epidermal growth factor receptor 2 (HER2) expression has led a repurpose current prognostic system. Little known about its correlation NAT.
Blood vessel formation generates unique vascular patterns in each individual. The principles governing the apparent stochasticity of this process remain to be elucidated. Using mathematical methods, we find that transition between two fundamental morphogenetic programs – sprouting angiogenesis and remodeling is established by a shift on collective front-rear polarity endothelial cells. We demonstrate competition biochemical (VEGFA) mechanical (blood flow-induced shear stress) cues controls...
Abstract Introduction and objectives: Cyclin dependent kinase (CDK) 4/6 inhibitors along with endocrine therapy (ET) is the standard first-line for receptor (ER)-positive HER2-negative metastatic breast cancer. Three CDK have FDA EMA approval: abemaciclib, palbociclib ribociclib. They appear to notable differences in their pharmacokinetic characteristics ability inhibit every cyclin. Nevertheless, natural history of disease associated each inhibitor remains unclear. The aim this study...
Abstract Introduction and objectives Estrogen receptor positive (ER+) tumors are the most common form of breast cancer responsible for deaths from disease. Treatment ER+ comprises interventions that suppress estrogen production and/or target ER directly. While endocrine therapy has considerably reduced recurrence mortality cancer, de novo acquired resistance to this treatment remains a major challenge. In context, patient-derived organoids (PDOs), 3D structures composed epithelial cells,...
Abstract INTRODUCTION Human Epidermal Growth Factor Receptor (HER2) is overexpressed and/or amplified in 15-20% of breast cancer at time first diagnosis and associated with an aggressive clinical progression disease. Management HER2+ early cancer, include a combination sequential chemotherapy HER2-targeted therapy, which currently the gold standard care. Achieving pathological complete response (pCR) to after neoadjuvant therapy has been proposed as prognostic marker for prediction...
Abstract INTRODUCTION. In response to neoadjuvant therapy, pathological complete (pCR; lack of residual disease in breast and lymph nodes), has been proposed as a prognostic marker for long-term clinical outcomes, such disease-free (DFS) overall survival (OS), human epidermal growth factor receptor 2 (HER2)-positive triple-negative cancer. practice, recognizing those patients likely achieve responses proves challenging the oncologist, making identification new useful biomarkers vital. Here,...
Abstract Blood vessel formation generates unique vascular patterns in each individual. The principles governing the apparent stochasticity of this process remain to be elucidated. Using mathematical methods, we find that transition between two fundamental morphogenetic programs – sprouting angiogenesis and remodeling is established by a shift on collective front-rear polarity endothelial cells. We demonstrate competition biochemical (VEGFA) mechanical (blood flow-induced shear stress) cues...