C. Sevillano

ORCID: 0000-0001-8689-3580
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About
Contact & Profiles
Research Areas
  • Potato Plant Research
  • Banana Cultivation and Research
  • Glaucoma and retinal disorders
  • Intraocular Surgery and Lenses
  • Ocular Oncology and Treatments
  • Cancer Genomics and Diagnostics
  • Retinal and Macular Surgery
  • Retinal and Optic Conditions
  • Retinal Imaging and Analysis
  • Topic Modeling
  • Vascular Tumors and Angiosarcomas
  • T-cell and Retrovirus Studies
  • Histiocytic Disorders and Treatments
  • Biomedical Text Mining and Ontologies
  • Ocular Infections and Treatments
  • Animal Disease Management and Epidemiology
  • Radiomics and Machine Learning in Medical Imaging
  • Sarcoma Diagnosis and Treatment
  • Vasculitis and related conditions
  • Tumors and Oncological Cases
  • Hematopoietic Stem Cell Transplantation
  • Digital Imaging in Medicine
  • Natural Language Processing Techniques
  • Cerebral Venous Sinus Thrombosis
  • Genetic and rare skin diseases.

The University of Texas MD Anderson Cancer Center
2024-2025

Hospital Universitario Virgen del Rocío
2023-2024

Vall d'Hebron Institute of Oncology
2023

CIBBIM-Nanomedicine
2023

Complejo Hospitalario de Pontevedra
2008-2022

Complexo Hospitalario Universitario A Coruña
2014-2022

Hospital de Cruces
2011

The cancer stem cell (SC) theory proposes that a population of SCs serves as the driving force behind fundamental tumor processes, including metastasis, recurrence, and resistance to therapy. standard care for patients with stage III high-risk II colorectal (CRC) includes surgery adjuvant chemotherapy. Fluoropyrimidines their combination oxaliplatin increased cure rates, being able eradicate occult metastatic SC in fraction patients. treatment unresectable CRC is based on chemotherapy,...

10.3390/ijms25116220 article EN International Journal of Molecular Sciences 2024-06-05

Abstract Background Checkpoint agonists utomilumab (4-1BB agonist) and ivuxolimab (OX40 enhance Teffector cell function. Preclinical studies suggest that combining these drugs with avelumab (anti-PD-L1 antibody) can potentially synergize this effect. In addition, tissue abscopal effects of radiation therapy may improve antigen presentation, complementing PD-L1 blockade. We conducted a single institution, open-label, multi-arm, non-randomized, phase 1/2 clinical trial in combination...

10.1093/oncolo/oyaf032 article EN cc-by The Oncologist 2025-03-01

A patient in his 40s with splenic angiosarcoma metastatic to the liver underwent splenectomy, chemotherapy, and partial hepatectomy before being treated on a clinical trial CTLA4 PD1 inhibitors. He had received pneumococcal meningococcal vaccines post-splenectomy. On week 10, he developed grade 3 immune-related colitis, successfully anti-tumor necrosis factor-alpha inhibitor infliximab steroids. After 4 cycles of treatment, scans showed response. resumed anti-PD1 therapy, 6 hours after...

10.3389/fimmu.2024.1366271 article EN cc-by Frontiers in Immunology 2024-05-08

<b><i>Objective:</i></b> The aim of this study was to investigate the association between rhegmatogenous retinal detachment (RRD) and solar radiation in northwestern Spain. <b><i>Methods:</i></b> All RRD cases Pontevedra from 2008 2014 were retrospectively analyzed. Climatological data 4 weather stations area collected. incidence investigated. <b><i>Results:</i></b> A total 256 identified. There a seasonal variation with...

10.1159/000503070 article EN Ophthalmologica 2019-10-17

A 45-year-old-man presented a slightly painful proptosis and diplopia for 7 months. He had been kept elsewhere on oral steroids without evidence of any clinical response over an 8-week period with suspected diagnosis inflammatory pseudotumor upon referral to our clinic. An intraoperative biopsy positive primary liposarcoma was followed by debulking surgery. Exenteration radiotherapy were performed after pathologic confirmation this diagnosis. No recurrence has observed 2 years follow-up. We...

10.1097/scs.0b013e3182108fdd article EN Journal of Craniofacial Surgery 2011-05-01

A 84-year-old-woman presented a painless eyelid mass in her right eyelid. biopsy was made and the anatomopathologic study showed spiradenoma with malignant changes. The patient rejected any kind of treatment spite prognosis lesion. Radiological pathological features this infrequent tumour are discussed.

10.3109/01676830.2011.579682 article EN Orbit 2011-07-22

RESUMENCaso clínico: Se presenta un caso de desprendimiento la membrana Descemet tras cirugía catarata mediante facoemulsificación tratado con éxito utilizando SF6 al 20% intracameral.Discusión: exponen los posibles mecanismos etiopatogénicos y se comentan las distintas opciones terapéuticas.Enfatizamos necesidad adop

10.4321/s0365-66912008000900008 article ES cc-by-nc Archivos de la Sociedad Española de Oftalmología 2008-09-01

10.1016/j.oftal.2014.07.013 article EN Archivos de la Sociedad Española de Oftalmología 2014-11-17

10.1016/j.oftale.2015.12.006 article ES Archivos de la Sociedad Española de Oftalmología (English Edition) 2016-01-01

10.1016/j.oftale.2012.05.011 article ES Archivos de la Sociedad Española de Oftalmología (English Edition) 2012-03-01

1635 Background: Recruitment to phase I/II clinical trials have been reported vary between 30% and 55% across centers, primarily relying on in-person visits. However, with the onset of COVID-19 pandemic, there has a noticeable surge in telehealth consultations. Consequently, is currently dearth data available regarding this approach within context early phase-clinical trials. Methods: Data patient’s first visits Investigational Cancer Therapeutics (ICT), dedicated Phase I department at The...

10.1200/jco.2024.42.16_suppl.1635 article EN Journal of Clinical Oncology 2024-05-29

10.1016/j.oftal.2015.09.002 article EN Archivos de la Sociedad Española de Oftalmología 2015-11-11

How to treat a disease remains be the most common type of clinical question. Obtaining evidence-based answers from biomedical literature is difficult. Analogical reasoning with embeddings deep learning (embedding analogies) may extract such facts, although state-of-the-art focuses on pair-based proportional (pairwise) analogies as man:woman::king:queen ("queen = -man +king +woman").

10.2196/16948 article EN cc-by JMIR Medical Informatics 2020-05-04

10.1016/j.oftale.2015.10.006 article ES Archivos de la Sociedad Española de Oftalmología (English Edition) 2015-09-01

10.1016/j.oftal.2012.02.006 article EN Archivos de la Sociedad Española de Oftalmología 2012-11-10
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