A5028693685- CAR-T cell therapy research
- Advanced Breast Cancer Therapies
- BRCA gene mutations in cancer
- Renal and related cancers
- Acute Lymphoblastic Leukemia research
- RNA Interference and Gene Delivery
- Nutrition, Genetics, and Disease
- Inflammasome and immune disorders
- Autoimmune and Inflammatory Disorders Research
- Chronic Lymphocytic Leukemia Research
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- Cervical Cancer and HPV Research
- PARP inhibition in cancer therapy
- HER2/EGFR in Cancer Research
- Cytokine Signaling Pathways and Interactions
- Antibiotics Pharmacokinetics and Efficacy
- Hemoglobinopathies and Related Disorders
- COVID-19 and healthcare impacts
- Aortic aneurysm repair treatments
- Quantum Mechanics and Applications
- Aortic Disease and Treatment Approaches
- Histone Deacetylase Inhibitors Research
- Cancer-related Molecular Pathways
- Systemic Lupus Erythematosus Research
The University of Texas MD Anderson Cancer Center
2023-2025
La Jolla Institute for Immunology
2025
Indian Academy of Sciences
2023-2024
Kyoto University
2023-2024
RIKEN Center for Computational Science
2023-2024
Tris Pharma (United States)
2023-2024
University of Kalyani
2024
Maulana Abul Kalam Azad University of Technology, West Bengal
2024
Novartis (United States)
2012-2023
University of Minnesota
2010-2023
Ribociclib (an oral, highly specific cyclin-dependent kinase 4/6 inhibitor) inhibits tumor growth in preclinical models with intact retinoblastoma protein (Rb+). This first-in-human study investigated the MTD, recommended dose for expansion (RDE), safety, preliminary activity, pharmacokinetics, and pharmacodynamics of ribociclib patients Rb+ advanced solid tumors or lymphomas.Patients received escalating doses (3-weeks-on/1-week-off continuous). Dose escalation was guided by a Bayesian...
Abstract Purpose: Tisagenlecleucel is an anti-CD19 chimeric antigen receptor (CAR19) T-cell therapy approved for the treatment of children and young adults with relapsed/refractory (r/r) B-cell acute lymphoblastic leukemia (B-ALL). Patients Methods: We evaluated cellular kinetics tisagenlecleucel, effect patient factors, humoral immunogenicity, manufacturing attributes on its kinetics, exposure-response analysis efficacy, safety pharmacodynamic endpoints in 79 patients across two studies...
Coronavirus outbreak has affected thousands of people in at least 186 countries which the cancer care delivery system apart from affecting overall health system. Cancer patients are more susceptible to coronavirus infection than individuals without as they an immunosuppressive state because malignancy and anticancer treatment. Oncologists should be attentive detect early, any type advanced is much higher risk for unfavorable outcomes. Oncology communities must ensure that spend time home...
Smooth muscle cell (SMC) phenotypic switching has been increasingly detected in aortic aneurysm and dissection (AAD) tissues. However, the diverse SMC phenotypes AAD tissues mechanisms driving alterations remain to be identified.
The confluence of new technologies with artificial intelligence (AI) and machine learning (ML) analytical techniques is rapidly advancing the field precision oncology, promising to improve diagnostic approaches therapeutic strategies for patients cancer. By analyzing multi-dimensional, multiomic, spatial pathology, radiomic data, these enable a deeper understanding intricate molecular pathways, aiding in identification critical nodes within tumor's biology optimize treatment selection....
Abstract Objective To assess dosing, preliminary safety, and efficacy of canakinumab, a fully human anti–interleukin‐1β (anti–IL‐1β) antibody, in children with systemic juvenile idiopathic arthritis (JIA) active features. Methods In this phase II, multicenter, open‐label, dosage‐escalation study, JIA who were ≥4 years age, had fever, receiving ≤0.4 mg/kg/day corticosteroids administered single subcutaneous dose 0.5–9 mg/kg body weight, redosed upon relapse. Response to treatment was assessed...
Abstract The anti-CD19 chimeric antigen receptor (CAR)–T cell therapy tisagenlecleucel was evaluated in the global, phase 2 JULIET study adult patients with relapsed/refractory diffuse large B-cell lymphoma (DLBCL). We correlated cellular kinetics clinical/product parameters 111 treated JULIET. Tisagenlecleucel persistence responders and nonresponders, respectively, demonstrated for 554 400 days maximum by flow cytometry 693 374 quantitative polymerase chain reaction (qPCR). No relationships...
Cryopyrin-associated periodic syndrome (CAPS) represents a spectrum of three auto-inflammatory syndromes, familial cold (FCAS), Muckle-Wells (MWS), and neonatal-onset multisystem inflammatory disease/chronic infantile neurological cutaneous articular (NOMID/CINCA) with etiology linked to mutations in the NLRP3 gene resulting elevated interleukin-1β (IL-1β) release. CAPS is rare hereditary disease, which may start early childhood requires life-long treatment. Canakinumab, fully human...
Renal failure occurs when one or both kidneys are unable to function properly. It can be classified into two types: acute and chronic. Acute renal is a sudden temporary condition, while chronic develops gradually lead permanent kidney damage. injury arises the lose their ability filter waste from bloodstream effectively. This result in accumulation of harmful products an imbalance blood's chemical composition. Previously, was referred as injury. Hospitalized patients, particularly those...
The F/A-18 Hornet aircraft with the original flight control law exhibited a nonlinear out-of-control phenomenon known as falling-leaf mode. This unstable mode was suppressed by modifying law. paper employs an example to investigate applicability of linear analysis tools for detecting inherently phenomenon. A high-fidelity model is developed controller using High-Alpha Research Vehicle aerodynamic data in open literature. variety methods are used robustness properties (baseline) and revised...
The F/A-18 Hornet aircraft with the original flight control law exhibited a nonlinear out-of-control phenomenon known as falling-leaf mode. This unstable mode was suppressed by modifying law. paper employs an example to investigate applicability of linear analysis tools for detecting inherently phenomenon. A high-fidelity model is developed controller using High-Alpha Research Vehicle aerodynamic data in open literature. variety methods are used robustness properties (baseline) and revised...
2528^ Background: LEE011, an orally bioavailable, highly specific CDK4/6 inhibitor, causes cell cycle arrest and tumor growth inhibition in multiple preclinical models with intact retinoblastoma protein (pRb+). Methods: Pts withpRb+ advanced solid tumors lymphomas were treated escalating doses of LEE011 on a 21-of-28-d or continuous schedule. Dose escalation was guided by Bayesian Logistic Regression Model overdose control principle. Primary objective: to establish the MTD and/or RP2D...
<h3>Objective</h3> To study efficacy and safety of escalating doses canakinumab, a fully human anti-IL-1β monoclonal antibody in the severe cryopyrin-associated periodic syndrome, neonatal-onset multisystem inflammatory disease (NOMID). <h3>Methods</h3> 6 patients were enrolled this 24-month, open-label phase I/II study. All underwent anakinra withdrawal. The initial subcutaneous canakinumab dose was 150 mg (or 2 mg/kg ≤40 kg) or 300 4 mg/kg) with escalation up to 600 8 every weeks. Full...
When aortic cells are under stress, such as increased hemodynamic pressure, they adapt to the environment by modifying their functions, allowing aorta maintain its strength. To understand regulation of this adaptive response, we examined transcriptomic and epigenomic programs in smooth muscle (SMCs) during response AngII (angiotensin II) infusion determined importance protecting against aneurysm dissection (AAD).
Abstract The decades-long gap in antibiotic discovery has led to a significant health crisis due antimicrobial resistance (AMR). bacterial genus Xenorhabdus , which forms symbiotic relationships with the soil nematode Steinernema are known secrete variety of compounds potential effectiveness against AMR. These primarily bio-synthesized by non-ribosomal peptide synthetases (NRPS) and polyketide synthetase (PKS) genes. In this study, we report that X. szentirmaii produces high levels activity...
The decades-long gap in antibiotic discovery has led to a significant health crisis due antimicrobial resistance (AMR). bacterial genus Xenorhabdus , which forms symbiotic relationships with the soil nematode Steinernema are known secrete variety of compounds potential effectiveness against AMR. These primarily bio-synthesized by non-ribosomal peptide synthetases (NRPS) and polyketide synthase (PKS) genes. In this study, we report that X. szentirmaii produces high levels activity during...