A5029027727- CAR-T cell therapy research
- Salivary Gland Tumors Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Facial Trauma and Fracture Management
- Ear and Head Tumors
- Tumors and Oncological Cases
- Oral and Maxillofacial Pathology
- Bone Tumor Diagnosis and Treatments
- RNA Interference and Gene Delivery
- Head and Neck Surgical Oncology
- Meningioma and schwannoma management
- Mass Spectrometry Techniques and Applications
- Neurofibromatosis and Schwannoma Cases
- Biosimilars and Bioanalytical Methods
- Osteomyelitis and Bone Disorders Research
- Tracheal and airway disorders
- Soft tissue tumor case studies
- Reconstructive Surgery and Microvascular Techniques
- Sinusitis and nasal conditions
- Nasal Surgery and Airway Studies
- Reconstructive Facial Surgery Techniques
- Metabolomics and Mass Spectrometry Studies
- Facial Rejuvenation and Surgery Techniques
- Vascular Malformations and Hemangiomas
- Facial Nerve Paralysis Treatment and Research
The University of Texas Southwestern Medical Center
2019
University of North Texas
2014-2017
Novartis (United States)
2017
Osborne Head and Neck Institute
2006-2014
Inova Fairfax Hospital
2014
Virginia Commonwealth University
2014
Cedars-Sinai Medical Center
2005-2006
Charles R. Drew University of Medicine and Science
2004-2005
University of California, Los Angeles
2004
World Molecular Imaging Society
2003
Abiotic stresses such as drought, heat or salinity are a major cause of yield loss worldwide. Recent studies revealed that the acclimation plants to combination different environmental is unique and cannot be directly deduced from studying response each applied individually. Here we report on Arabidopsis thaliana salt stress using transcriptome analysis, physiological measurements mutants deficient in abscisic acid, salicylic jasmonic acid ethylene signaling. were found more susceptible...
Abstract Purpose: Tisagenlecleucel is an anti-CD19 chimeric antigen receptor (CAR19) T-cell therapy approved for the treatment of children and young adults with relapsed/refractory (r/r) B-cell acute lymphoblastic leukemia (B-ALL). Patients Methods: We evaluated cellular kinetics tisagenlecleucel, effect patient factors, humoral immunogenicity, manufacturing attributes on its kinetics, exposure-response analysis efficacy, safety pharmacodynamic endpoints in 79 patients across two studies...
Electrospray mass spectrometry is now a widely used technique for observing cell content of various biological tissues. However, electrospray techniques (liquid chromatography and direct infusion) often involve lysing group cells extracting the biomolecules interest, rather than sensitive, individual method to observe local chemistry. Presented here an approach combining nanomanipulator workstation with nanospray spectrometry, which allows extraction single cell, followed by rapid analysis...
She was treated with a process called carboxytherapy that resulted in great improvement of the scars minimal to no discomfort or down time. Carbon Dioxide (CO2) therapy first introduced France for cutaneous use.1 CO2 is non-toxic gas naturally produced by cells as they undergo metabolism. As accumulates tissues it induces dilatation capillaries and results increased blood flow facilitate its removal.2 Lately, injection has been used improve stretch marks, skin laxity, cellulite, dark circles...
Autosomal-dominant Schnyder corneal dystrophy (SCD) is characterized by opacification owing to overaccumulation of cholesterol. SCD caused mutations in UBIAD1, which utilizes geranylgeranyl pyrophosphate (GGpp) synthesize vitamin K2. Using cultured cells, we previously showed that sterols trigger binding UBIAD1 the cholesterol biosynthetic enzyme HMG CoA reductase (HMGCR), thereby inhibiting its endoplasmic reticulum (ER)-associated degradation (ERAD) (Schumacher et al. 2015). GGpp triggers...
A new single Peltier element ablation cell is described and its applicability to biological sampling discussed evaluate performance.
The cellular metabolome is considered to be a representation of phenotype and response changes internal or external events. Methods expand the coverage expansive physiochemical properties that makeup currently utilize multi-step extractions chromatographic separations prior chemical detection, leading lengthy analysis times. In this study, single-step procedure for extraction separation sample using micro-capillary as separatory funnel achieve analyte partitioning within an organic/aqueous...
This is a case report of 28 year old male with history left maxillary tumor. The defect was treated utilizing customized 3D implant. CT guided implants, allow for preoperative production an implant that precisely represents the anatomical defect. These implants decrease operative time as they eliminate need to hand carve reduce removal healthy bone, bone grafting, and promote effective planning implantation while improving surgical accuracy. Three dimensional modeling also allows improves...
e15056 Background: Analyses supporting a safe and efficacious dose for CAR therapies are not well defined vary across CAR-T programs. These analyses present key considerations to support tisagenlecleucel range. Methods: Data from pivotal phase II studies in relapsed/refractory (r/r) pediatric young adult acute lymphoblastic leukemia (B-ALL) patients (pts) (ELIANA [NCT02435849, n = 75]; ENSIGN [NCT02228096, 29]) diffuse large B cell lymphoma (DLBCL) pts (JULIET [NCT02445248, 99]) were used...