A5014785750- Hippo pathway signaling and YAP/TAZ
- Cellular Mechanics and Interactions
- Angiogenesis and VEGF in Cancer
- Congenital heart defects research
- RNA Research and Splicing
- Obsessive-Compulsive Spectrum Disorders
- Pulmonary Hypertension Research and Treatments
- RNA modifications and cancer
- Neonatal Respiratory Health Research
- Listeria monocytogenes in Food Safety
- Body Image and Dysmorphia Studies
- Developmental Biology and Gene Regulation
- Cell Adhesion Molecules Research
- Essential Oils and Antimicrobial Activity
- Photoreceptor and optogenetics research
- Platelet Disorders and Treatments
- Olfactory and Sensory Function Studies
- Forest Insect Ecology and Management
- Molecular Biology Techniques and Applications
- Wnt/β-catenin signaling in development and cancer
- Single-cell and spatial transcriptomics
- Plant and Fungal Interactions Research
- Autism Spectrum Disorder Research
- Microbial Inactivation Methods
- Proteoglycans and glycosaminoglycans research
Champalimaud Foundation
2025
University of Lisbon
2010-2023
Instituto Politécnico de Lisboa
2020
Korea Advanced Institute of Science and Technology
2019
Instituto Superior de Gestão
2014
Endothelial cells respond to molecular and physical forces in development vascular homeostasis. Deregulation of endothelial responses flow-induced shear is believed contribute many aspects cardiovascular diseases including atherosclerosis. However, how signals shear-mediated integrate regulate patterning poorly understood. Here we show that non-canonical Wnt signalling regulates sensitivity forces. Loss Wnt5a/Wnt11 renders more sensitive shear, resulting axial polarization migration against...
Morphogenesis of hierarchical vascular networks depends on the integration multiple biomechanical signals by endothelial cells, cells lining interior blood vessels. Expansion arises through sprouting angiogenesis, a process involving extensive cell rearrangements and collective migration. Yet, mechanisms controlling angiogenic behavior remain poorly understood. Here, we show this is regulated non-canonical Wnt signaling. We identify that Wnt5a specifically activates Cdc42 at junctions...
Blood-vessel formation generates unique vascular patterns in each individual. The principles governing the apparent stochasticity of this process remain to be elucidated. Using mathematical methods, we find that transition between two fundamental morphogenetic programs—sprouting angiogenesis and remodeling—is established by a shift collective front-to-rear polarity endothelial cells mouse retina. We demonstrate competition biochemical (VEGFA) mechanical (blood-flow-induced shear stress) cues...
Obsessive-compulsive disorder (OCD) may develop following brain lesions, but lesion distribution and connectivity patterns are unknown. OCD-associated identified from systematic literature search, were traced on common space compared to control lesions (N=608). Topography was analyzed using atlases, location networks computed normative functional (N=1000). Lesional network maps (LNMs) contrasted data primary OCD. Among 129 case-descriptions of lesional OCD, (n=40) more specifically located...
Grapevine is one of the most cultivated fruit crop worldwide with Vitis vinifera being species highest economical importance. Being highly susceptible to fungal pathogens and increasingly affected by environmental factors, it has become an important agricultural research area, where gene expression analysis plays a fundamental role. Quantitative reverse transcription polymerase chain reaction (qRT-PCR) currently amongst powerful techniques perform studies. Nevertheless, accurate...
The ability of endothelial cells to respond blood flow is fundamental for the correct formation and maintenance a functional hierarchically organized vascular network. Defective responses, in particular related high conditions, have been associated with atherosclerosis, stroke, arteriovenous malformations, neurodegenerative diseases. Yet, molecular mechanisms involved response are still poorly understood. Here, we described development validation 96-wells fluidic system, interchangeable cell...
Adaptation to breathing is a critical step in lung function and it crucial for organismal survival. Alveoli are the gas exchange units their development, from late embryonic early postnatal stages, requires feedbacks between multiple cell types. However, how crosstalk alveolar types modulated anticipate adaptation still unclear. Here, we uncovered synchronous alternative splicing switch genes developing mouse lungs at transition birth, identified hnRNP A1, Cpeb4, Elavl2/HuB as putative...
Blood vessel formation generates unique vascular patterns in each individual. The principles governing the apparent stochasticity of this process remain to be elucidated. Using mathematical methods, we find that transition between two fundamental morphogenetic programs – sprouting angiogenesis and remodeling is established by a shift on collective front-rear polarity endothelial cells. We demonstrate competition biochemical (VEGFA) mechanical (blood flow-induced shear stress) cues controls...
Abstract Gas exchanges are ensured by lung alveoli, which mainly composed epithelial alveolar type 1 (AT1), 2 (AT2) and capillary endothelial cells (ECs). Alveologenesis starts during late embryonic development continues after birth relies on extensive biochemical crosstalk between these cell types. How this is modulated to anticipate accommodate the radical changes occurring at still unclear. We investigated alternative splicing (AS) postnatal transition performing RNAseq of mouse lungs...
Abstract Blood vessel formation generates unique vascular patterns in each individual. The principles governing the apparent stochasticity of this process remain to be elucidated. Using mathematical methods, we find that transition between two fundamental morphogenetic programs – sprouting angiogenesis and remodeling is established by a shift on collective front-rear polarity endothelial cells. We demonstrate competition biochemical (VEGFA) mechanical (blood flow-induced shear stress) cues...