A5089723627- Microfluidic and Capillary Electrophoresis Applications
- Microfluidic and Bio-sensing Technologies
- Electrowetting and Microfluidic Technologies
- Innovative Microfluidic and Catalytic Techniques Innovation
- Nanofabrication and Lithography Techniques
- Intravenous Infusion Technology and Safety
- Sensor Technology and Measurement Systems
- Electrostatic Discharge in Electronics
- Biosensors and Analytical Detection
- 3D Printing in Biomedical Research
- Flow Measurement and Analysis
- Heat Transfer and Boiling Studies
- Indoor Air Quality and Microbial Exposure
- Electrohydrodynamics and Fluid Dynamics
- Maritime Transport Emissions and Efficiency
- Advanced Sensor and Energy Harvesting Materials
- Scientific Measurement and Uncertainty Evaluation
- Heat Transfer and Optimization
- Characterization and Applications of Magnetic Nanoparticles
- Fluid Dynamics and Thin Films
- Non-Destructive Testing Techniques
- Micro and Nano Robotics
- Hydraulic flow and structures
- Hippo pathway signaling and YAP/TAZ
- Analytical Chemistry and Chromatography
Instituto de Engenharia de Sistemas e Computadores Microsistemas e Nanotecnologias
2017-2025
Instituto Politécnico de Lisboa
2015-2025
University of Lisbon
2015-2025
Instituto de Engenharia de Sistemas e Computadores Investigação e Desenvolvimento
2019-2025
Instituto Superior Técnico
2023
Institute for Biotechnology and Bioengineering
2023
Center for Innovation
2012-2015
Bioaerosols, a subset of aerosols released from the biosphere, can carry pathogens, and include particles with diameters nanometres to few micrometres. They remain suspended indoors travel significant distances. Bioaerosol studies play vital role in public health, as bioaerosols are an effective route for human animal pathogen transmission, especially production handling facilities, which considered hotspots emergence zoonotic pathogens. The ‘One Health‘ approach, interconnects human,...
This study aimed to experimentally validate a computational fluid dynamics (CFD) model, using micro-particle image velocimetry (micro-PIV) measurements of the irrigation flow velocity field developed in confluent canals during with side-vented needle.A microchip canals, manufactured polydimethylsiloxane was used micro-PIV analysis needle placed 3 mm from end confluence canals. Velocity fields and profiles were recorded for rates 0.017 0.1 ml/s compared those predicted CFD numerical...
In this work, we propose an artificial neural network (ANN) for magnetic microcytometry pattern recognition and automated counting. The method is tested detecting analytes in the 2–3- <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\mu \text{m}$ </tex-math></inline-formula> range. cytometer composed of a disposable cartridge acquisition platform. contains microfluidic channels with...
Dimensional measurements are fundamental in microfluidic device manufacturing and performance. The main focus of this study is the measurement connection port sizes devices components and, accordingly, possible existence fluid leaks determined using flow rate error. associated with three different systems were laser interferometry through an optical measuring instrument, metrological traceability to national length standards. It was infer method greatest accuracy lowest uncertainty for...
Biomedical applications and point-of-use devices often rely on nanoparticle concentration strategies. In this paper, on-chip magnetic trapping manipulation of 300–500 nm superparamagnetic nanoparticles are achieved using thin-film planar circular copper coils. The trap configuration combining a central coil surrounded by four other coils, all connected in series, successfully enables simultaneous attraction repulsion, enhancing (MNP). repulsion has advantages over static permanent magnets,...
The ability of endothelial cells to respond blood flow is fundamental for the correct formation and maintenance a functional hierarchically organized vascular network. Defective responses, in particular related high conditions, have been associated with atherosclerosis, stroke, arteriovenous malformations, neurodegenerative diseases. Yet, molecular mechanisms involved response are still poorly understood. Here, we described development validation 96-wells fluidic system, interchangeable cell...
Abstract The present paper describes a compact point of care (POC) optical device for therapeutic drug monitoring (TDM). core the is disposable plastic chip where an immunoassay determination immunosuppressants takes place. designed in order to have ten parallel microchannels allowing simultaneous detection more than one analyte with replicate measurements. equipped microfluidic system, which provides sample mixing necessary chemicals and pumping samples, reagents buffers into measurement...
Abstract Infusion therapy is the most common form of used in health care. However, existing infusion devices show higher flow discrepancies as rates decrease to a few nL min −1 . As result, dosing errors can contribute morbidity and mortality patients. In scope project 18HLT08 MeDD II – Metrology for drug delivery, this investigation aims at development silicon microchip pump capable steadily continuously dispense very low The fabrication methodologies explored here use combination typical...
Optically detectable labels and probes are commonly used in bioapplications. Together with the miniaturization of analytical platforms based on microfluidic technology, tuneable properties, they yield unparalleled opportunities towards faster, cheaper more efficient biomolecule analysis. This work describes preparation testing uniformly shaded polydimethylsiloxane (PDMS) membranes devices to enhance or inhibit optical detection fluorescent labels. The pigmented black-PDMS nanocomposite...
Integration of point-of-care assays can be facilitated with the use actuated magnetic beads (MB) to perform testing in less expensive settings enable delivery cost-effective care. In this paper we present six different designs planar microelectromagnets traps (MEMT) four external coils series and one central coil connected for an opposite direction manipulation MB microfluidic flows. The development a simulation tool rapid efficient optimization by presenting influence system variables on...
Soil improvement using ureolytic bacteria or other biological agents is a promising technique currently under investigation. It based on the precipitation of calcium carbonate (biocement) due to enzymatic hydrolysis urea. The biocement produced clogs soil pores, consequently bonding grains and increasing overall strength stiffness while reducing permeability. This study focused mainly pore clogging effects. effect enzyme feeding solution concentrations was studied in small test tubes find...
Hydrodynamic resistance is a critical parameter in microfluidics, affecting device functionality and performance. However, quantifying hydrodynamic microfluidics challenge due to many influencing factors the difficulties associated with precise measurements of low flow rates (&lt; 10 L/min) pressure drops 5 kPa). This article presents simple experimental test method for assessing resistance, correlating theoretical numerical calculations. The results demonstrate good agreement between...
This protocol describes the fabrication of microfluidic devices using Polydimethylsiloxane (PDMS), a silicone-based organic polymer widely used in microfluidics due to its optical transparency, biocompatibility, flexibility, and ease molding. The involves several key steps, including preparation glass hardmask, soft lithography PDMS casting.