A5100642632- Liver Disease Diagnosis and Treatment
- Inflammatory Bowel Disease
- Microscopic Colitis
- Eosinophilic Esophagitis
- Liver Disease and Transplantation
- Alcohol Consumption and Health Effects
- Colorectal Cancer Screening and Detection
- Esophageal and GI Pathology
- Hepatitis C virus research
- Helicobacter pylori-related gastroenterology studies
- Esophageal Cancer Research and Treatment
- Cancer Genomics and Diagnostics
- Diverticular Disease and Complications
- Sexual function and dysfunction studies
- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastroesophageal reflux and treatments
- Radiomics and Machine Learning in Medical Imaging
- Gastrointestinal disorders and treatments
- MRI in cancer diagnosis
- Complement system in diseases
- Gastrointestinal motility and disorders
- Anesthesia and Pain Management
- Autoimmune and Inflammatory Disorders
- Stoma care and complications
Centro Hospitalar Lisboa Norte
2016-2024
Hospital de Santa Maria
2013-2023
University of Lisbon
1988-2020
Despite recent advances in treatment of viral hepatitis, liver-related mortality is high, possibly owing to the large burden advanced alcohol-related liver disease (ALD). We investigated whether patients with ALD are initially seen at later stages development than hepatitis C virus (HCV) infection or other etiologies.We performed a cross-sectional study 3453 consecutive either early (1699 and 1754 disease) 17 tertiary care gastrointestinal units worldwide, from August 2015 through March...
Endoscopy is routinely performed in patients with inflammatory bowel disease to evaluate severity and guide important clinical decisions. However, variability the interpretation of endoscopic findings can significantly impact patient management. Fifty-eight gastroenterologists were invited participate an online survey including pictures video recordings colonoscopies ulcerative colitis (UC) Crohn’s (CD). Participants asked rate colorectal mucosa UC using Mayo subscore (MES), neo-terminal...
Abstract Colorectal cancer (CRC) is one of the most lethal malignancies. The extreme heterogeneity in survival rate driving need for new prognostic biomarkers. Human endogenous retroviruses (hERVs) have been suggested to influence tumor progression, oncogenesis and elicit an immune response. We examined multiple next-generation sequencing (NGS)-derived biomarkers 114 CRC patients with paired whole-exome whole-transcriptome (WES WTS, respectively). First, we demonstrate that median expression...
Colorectal cancer (CRC) is the third most common and second deathly worldwide. It a very heterogeneous disease that can develop via distinct pathways where metastasis primary cause of death. Therefore, it crucial to understand molecular mechanisms underlying metastasis. RNA-sequencing an essential tool used for studying transcriptional landscape. However, high-dimensionality gene expression data makes selecting novel metastatic biomarkers problematic. To distinguish early-stage CRC patients...
Abstract Background & Aims Chronic liver disease is a major worldwide cause of morbidity and mortality. Palliative care policies are not clearly established in chronic disease. The NECPAL CCOMS ‐ ICO © ( NEC esidades PAL iativas/Palliative Needs) tool to identify palliative needs, including section for Aim: aim this study was needs patients hospitalised tertiary referral Liver Unit. Methods Single‐centre prospective observational study. One hundred twenty with cirrhosis were included...
Acute severe colitis (ASC) remains a challenging complication of ulcerative colitis. The early identification patients who will not respond to optimal therapy is warranted. Increasing evidence suggests that endoscopy may play role in predicting important outcomes acute colitis.The endoscopic activity consecutive with was evaluated using the Mayo sub-score (Mayo) and index severity (UCEIS). Two segmental indexes were also produced by summing scores rectum sigmoid (seg-Mayo seg-UCEIS,...
Alcohol abuse can result in a spectrum of liver injury that ranges from mild fatty infiltration to alcoholic hepatitis (AH), cirrhosis, and hepatocellular carcinoma. The present study aimed evaluate current scoring systems predicting short-term long-term mortality because AH.Records 170 consecutive patients with AH admitted tertiary center between January 2005 October 2015 were reviewed. Clinical biochemical parameters retrieved for the assessment scores day admission (D1) seventh...
Flexible esophagogastroduodenoscopy is the gold standard for removing FB of upper gastrointestinal tract. However large sharped are usually challenging to remove and subtype that most often requires surgery. We describe a case patient with dental prothesis impacted in proximal oesophagus. After failed conventional approach, we made successful attempt two regular scopes independent operators.
Marques da Costa, Pedro MD, MSci; Tato Marinho, Rui PhD; Cortez-Pinto, Helena Luís Velosa, José PhD Author Information
Venomous snakebites are relatively rare in Portugal. Pediatric victims present with greater severity and at risk of fatal complications. Clinical management protocols the gold standard care worldwide. We report two cases venomous adder bites pediatric patients. Based on a literature review we also discuss clinical treatment protocol that ensures multidisciplinary updated practice by medical teams. A mordedura de ofídio venenoso é uma situação rara em Quando ocorre idade pediátrica apresenta...
Background: Up to 25% of patients with ulcerative colitis will be admitted acute severe (ASC).Although the majority respond intravenous steroids, a third require rescue therapy or surgery.Endoscopy is mandatory in ASC, but its role predicting important outcomes has seldom been evaluated.Methods: The electronic records our centre between January 1993 and October 2015 according Truelove-Witts criteria, were reviewed.For each patient, endoscopic Mayo (Mayo) Ulcerative Colitis Endoscopic Index...
Background: Up to 25% of patients with ulcerative colitis will be admitted acute severe (ASC).Although the majority respond intravenous steroids, a third require rescue therapy or surgery.Endoscopy is mandatory in ASC, but its role predicting important outcomes has seldom been evaluated.Methods: The electronic records our centre between January 1993 and October 2015 according Truelove-Witts criteria, were reviewed.For each patient, endoscopic Mayo (Mayo) Ulcerative Colitis Endoscopic Index...
Background: Up to 25% of patients with ulcerative colitis will be admitted acute severe (ASC).Although the majority respond intravenous steroids, a third require rescue therapy or surgery.Endoscopy is mandatory in ASC, but its role predicting important outcomes has seldom been evaluated.Methods: The electronic records our centre between January 1993 and October 2015 according Truelove-Witts criteria, were reviewed.For each patient, endoscopic Mayo (Mayo) Ulcerative Colitis Endoscopic Index...
Heart involvement in systemic sclerosis (SSc) affects the prognosis of disease when clinically evident. SSc may be associated with left ventricular (LV) microvascular obstruction and micronecrosis, which is a possible determinant dysfunction, heart failure sudden death. The aim this study was to assess, patients (pts) SSc, prevalence patterns myocardial fibrosis estimate its relationship LV function clinical data. Methods: We included 31 consecutive pts 27 female, 54 ± 9 year-old, after...